Results 11 to 20 of about 2,138,040 (291)
Current Opinion in Immunology, 2010 Innate immunity is an exciting area of research in rhinology because emerging evidence suggests that abnormal local immune responses, rather than pathogen-specific adaptive immunity, may play a more important role in the pathogenesis of chronic rhinosinusitis (CRS).
Artis, D., Tschopp, J.
+10 more sources
The Epitranscriptome and Innate Immunity [PDF]
PLOS Genetics, 2015 Our knowledge of the variety and abundances of RNA base modifications is rapidly increasing. Modified bases have critical roles in tRNAs, rRNAs, translation, splicing, RNA interference, and other RNA processes, and are now increasingly detected in all types of transcripts.
O'Connell, Mary +2 more
openaire +5 more sources
, 2022 AbstractResearch on the innate immunity has accelerated over the last decades. The main reason for this has been the discovery of receptors recognizing danger molecules from pathogens. This has been facilitated through genome and transcriptome sequencing of different fish species.
Dalmo, Roy Ambli, Bøgwald, Jarl
openaire +2 more sources
The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans
Nature Communications, 2020 lncRNAs are transcriptional regulators, but little is known of them functioning as negative feedback regulators of inflammation in humans. Here, the authors show that the human lncRNA LUCAT1 sequesters STAT1 to limit JAK/STAT signaling and the ...
Shiuli Agarwal +7 more
doaj +1 more source
Clinical & Translational Immunology, 2023 Objectives Novel host‐targeted therapeutics could treat severe influenza A virus (IAV) infections, with reduced risk of drug resistance. LAT8881 is a synthetic form of the naturally occurring C‐terminal fragment of human growth hormone.
Christopher M Harpur +7 more
doaj +1 more source
TLR4 links innate immunity and fatty acid-induced insulin resistance.
Journal of Clinical Investigation, 2006 TLR4 is the receptor for LPS and plays a critical role in innate immunity. Stimulation of TLR4 activates proinflammatory pathways and induces cytokine expression in a variety of cell types.
Hang Shi +5 more
semanticscholar +1 more source
Journal of Neuroinflammation, 2023 Proper sight is not possible without a smooth, transparent cornea, which is highly exposed to environmental threats. The abundant corneal nerves are interspersed with epithelial cells in the anterior corneal surface and are instrumental to corneal ...
Alexia Vereertbrugghen +10 more
doaj +1 more source
Targeting RIP Kinases in Chronic Inflammatory Disease
Biomolecules, 2021 Chronic inflammatory disorders are characterised by aberrant and exaggerated inflammatory immune cell responses. Modes of extrinsic cell death, apoptosis and necroptosis, have now been shown to be potent drivers of deleterious inflammation, and mutations
Mary Speir +4 more
doaj +1 more source
Frontiers in Immunology, 2020 Paneth cells contribute to intestinal innate immunity by sensing bacteria and secreting α-defensin. In Institute of Cancer Research (ICR) mice, α-defensin termed cryptdin (Crp) in Paneth cells consists of six major isoforms, Crp1 to 6.
Kiminori Nakamura +9 more
doaj +1 more source
Toll-like receptors in innate immunity.
International Immunology, 2004 Functional characterization of Toll-like receptors (TLRs) has established that innate immunity is a skillful system that detects invasion of microbial pathogens.
K. Takeda, S. Akira
semanticscholar +1 more source