Results 11 to 20 of about 448,147 (237)
A functional DC cross talk promotes human ILC homeostasis in humanized mice
Blood Advances, 2017 : Humanized mice harboring human hematopoietic systems offer a valuable small-animal model to assess human immune responses to infection, inflammation, and cancer.
Silvia Lopez-Lastra +8 more
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The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans
Nature Communications, 2020 lncRNAs are transcriptional regulators, but little is known of them functioning as negative feedback regulators of inflammation in humans. Here, the authors show that the human lncRNA LUCAT1 sequesters STAT1 to limit JAK/STAT signaling and the ...
Shiuli Agarwal +7 more
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Journal of Neuroinflammation, 2023 Proper sight is not possible without a smooth, transparent cornea, which is highly exposed to environmental threats. The abundant corneal nerves are interspersed with epithelial cells in the anterior corneal surface and are instrumental to corneal ...
Alexia Vereertbrugghen +10 more
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Frontiers in Immunology, 2020 Paneth cells contribute to intestinal innate immunity by sensing bacteria and secreting α-defensin. In Institute of Cancer Research (ICR) mice, α-defensin termed cryptdin (Crp) in Paneth cells consists of six major isoforms, Crp1 to 6.
Kiminori Nakamura +9 more
doaj +1 more source
Clinical & Translational Immunology, 2023 Objectives Novel host‐targeted therapeutics could treat severe influenza A virus (IAV) infections, with reduced risk of drug resistance. LAT8881 is a synthetic form of the naturally occurring C‐terminal fragment of human growth hormone.
Christopher M Harpur +7 more
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Mosquito Innate Immunity [PDF]
Insects, 2018 Mosquitoes live under the endless threat of infections from different kinds of pathogens such as bacteria, parasites, and viruses. The mosquito defends itself by employing both physical and physiological barriers that resist the entry of the pathogen and the subsequent establishment of the pathogen within the mosquito.
Ankit Kumar +6 more
openaire +3 more sources
Targeting RIP Kinases in Chronic Inflammatory Disease
Biomolecules, 2021 Chronic inflammatory disorders are characterised by aberrant and exaggerated inflammatory immune cell responses. Modes of extrinsic cell death, apoptosis and necroptosis, have now been shown to be potent drivers of deleterious inflammation, and mutations
Mary Speir +4 more
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Innate Nutritional Immunity [PDF]
The Journal of Immunology, 2018 Abstract Iron (Fe) is an essential micronutrient for both microbes and their hosts. The biologic importance of Fe derives from its inherent ability to act as a universal redox catalyst, co-opted in a variety of biochemical processes critical to maintain life.
Gabriel Núñez +2 more
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Metabolites, 2020 Changes in modern dietary habits such as consumption of Western-type diets affect physiology on several levels, including metabolism and inflammation. It is currently unclear whether changes in systemic metabolism due to dietary interventions are long ...
Mario A. Lauterbach +2 more
doaj +1 more source
Proceedings of the National Academy of Sciences, 2004 The capacity to mount an immune response that eliminates infection of a host by a microbial pathogen is critical for species survival and propagation. Mammals have developed complex immune systems that integrate innate responses, such as phagocytosis and the production of antimicrobial peptides after Toll-like receptor activation, along with adaptive ...
John A T, Young, Andrew, Dillin
openaire +2 more sources