Results 211 to 218 of about 14,479 (218)

Integrative QSP Modeling of Cancer Stem Cells in Triple‐Negative Breast Cancer: Impacts on Tumor Immunity and Response to Immune Checkpoint Inhibitors

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 4, April 2026.
ABSTRACT Cancer stem cells (CSCs) contribute to an immunosuppressive microenvironment through complex mechanisms and tumor‐immune interactions. However, the key determinants of CSC characteristics in driving tumor progression, immune suppression, and response to ICIs remain unclear and require systematic investigation.
Junsheng Xue, Weizhe Jian, Tianyu Wang, Zhujun Jiang, Xinyu Hou, Qirui Yang, Tianyu Bao, Lei Cai, Enze Gan, Chen Liu, Tianyan Zhou   +10 more
wiley   +1 more source

High Sensitivity Cardiac Troponin I Detection via MP‐Locked Aptamer and Multimeric DNAzyme‐Coupled Hyperbranched Hybridization Chain Reaction

Small, Volume 22, Issue 20, 7 April 2026.
We report a magnetic particle anchored locked aptamer platform integrated with hyperbranched HCR and DNAzyme amplification for enzyme‐free, ultrasensitive detection of cardiac troponin I. The assay achieves a 0.25 ng/L detection limit within 25 minutes and enables cross‐species MI detection, with machine learning classification reaching 90% accuracy ...
Sayantan Tripathy, Sahil Sharma, Ng Ka Wai, Siddhant Jaitpal, Anthony Dongchau, Saugat Bhattacharyya, Sonya R. Wesselowski, Ashley B. Saunders, Gerard L. Coté, Samuel B. Mabbott   +9 more
wiley   +1 more source

Immuno-PET Imaging of CD93 Expression with ⁶⁴Cu-Radiolabeled NOTA-mCD93 ([⁶⁴Cu]Cu-NOTA-mCD93) and Insulin-Like Growth Factor Binding Protein 7 ([⁶⁴Cu]Cu-NOTA-IGFBP7). [PDF]

Mol Pharm
Li X, Song W, Engle JW, Mixdorf JC, Barnhart TE, Sun Y, Zhu Y, Cai W.   +7 more
europepmc   +1 more source

Unilateral mastication‐induced memory deficits linked to disrupted hippocampal cholesterol metabolism in rats

VIEW, Volume 7, Issue 2, April 2026.
Unilateral mastication, a common oral habit, induces cognitive decline in rats by disrupting hippocampal cholesterol metabolism. It triggers astrocyte hyperplasia, enhances cholesterol synthesis, impairs transport/degradation, and reduces 24‐hydroxycholesterol (24‐OHC), ultimately damaging synaptic function.
Xiaoting Zhai, Yifan Hu, Rongchen Xu, Xinyu Xu, Bowen Ma, Dongzong Huang, Hongchen Liu, Hongbo Li, Yuan Hu, Hua Jiang   +9 more
wiley   +1 more source

Molecular IgE Reactivity Profiling With Micro‐Arrayed Allergens Reveals Distinct Interregional Patterns of Sensitization and a Hypoallergenic Region in Türkiye

Allergy, Volume 81, Issue 4, Page 1247-1264, April 2026.
A prospective, systematic and cross‐sectional population study was performed involving 1000 adult subjects from five centers representing different climatic areas of Türkiye (Turkey). Molecular IgE profiling demonstrated substantial interregional variation and identified a hypoallergenic region in the easternmost area with a continental climate.
Alp Kazancioglu, Huey‐Jy Huang, Sengul Aksakal, Ismet Bulut, Maria‐Roxana Buzan, Kuan‐Wei Chen, Monica Daniela Cotarcă, Alexandra Dubovets, Pia Gattinger, Okan Gulbahar, Ali Fuat Kalyoncu, Alexander Karaulov, Evgenii Kozlov, Carmen Panaitescu, Thomas Schlederer, Daria Trifonova, Mikhail Tulaev, Murat Turk, Susanne Vrtala, Milena Weber, Lauriana‐Eunice Zbîrcea, Bulent Enis Sekerel, Rudolf Valenta   +22 more
wiley   +1 more source

Beyond PD‐1: Mechanisms of Resistance to Checkpoint Blockade in Classical Hodgkin Lymphoma and Next‐Generation Immune Strategies

European Journal of Haematology, Volume 116, Issue 4, Page 357-367, April 2026.
ABSTRACT PD‐1 inhibitors have reshaped the treatment landscape of classical Hodgkin lymphoma, yet a substantial proportion of patients exhibit primary or acquired resistance driven by tumor‐intrinsic alterations, immunosuppressive microenvironmental signals, metabolic constraints, and EBV‐mediated modulation.
Santino Caserta, Enrica Antonia Martino, Mamdouh Skafi, Maria Eugenia Alvaro, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Ernesto Vigna, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

Development of Zr-89-Ontuxizumab for in vivo TEM-1/endosialin PET applications [PDF]

, 2016
Lange, Sara E. S., Lapi, Suzanne E., O\u27Shannessy, Daniel J., Studer, Matthew, Van Tine, Brian A., Zheleznyak, Alex   +5 more
core   +1 more source

Report of the Scientific Committee of the Spanish Agency for Food Safety and Nutrition (AESAN) on the conservation conditions of foods made with eggs or egg products in retail establishments

Food Risk Assess Europe, Volume 4, Issue 2, April 2026.
Abstract Royal Decree 1021/2022, which regulates certain hygiene requirements for the production and marketing of foodstuffs in retail establishments, establishes that, in retail establishments, food made with raw egg subjected to heat treatment where a temperature equal to or greater than 70°C is reached for 2 seconds in the centre of the product or ...
Antonio Valero Díaz, María Dolores Rodrigo Aliaga, Rosa María Capita González, Baltasar Mayo Pérez, Azucena del Carmen Mora Gutiérrez, Fernando Pérez Rodríguez, Paula Arrabal Durán   +6 more
wiley   +1 more source