The development and characterization of a human mesothelioma in vitro 3D model to investigate immunotoxin therapy. [PDF]
PLoS ONE, 2011 Tumor microenvironments present significant barriers to penetration by antibodies and immunoconjugates. Tumor microenvironments, however, are difficult to study in vitro. Cells cultured as monolayers exhibit less resistance to therapy than those grown in
Xinran Xiang +8 more
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Alpha-particle emitting 213Bi-anti-EGFR immunoconjugates eradicate tumor cells independent of oxygenation. [PDF]
PLoS ONE, 2013 Hypoxia is a central problem in tumor treatment because hypoxic cells are less sensitive to chemo- and radiotherapy than normoxic cells. Radioresistance of hypoxic tumor cells is due to reduced sensitivity towards low Linear Energy Transfer (LET ...
Christian Wulbrand +6 more
doaj +4 more sources
Frontiers in Immunology, 2015 CD74 (invariant MHC class II) regulates protein trafficking and is a receptor for macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (D-DT/MIF-2).
Lara eValiño-Rivas +7 more
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A novel strategy for treatment of bladder cancer: Antibody-drug conjugates [PDF]
Investigative and Clinical Urology, 2022 In the past, there was no second-line chemotherapeutic agent suitable for use when urothelial carcinoma (UC) progressed to platinum-resistant UC. However, recently, several new treatment options, such as immune checkpoint inhibitors or targeted therapy ...
Jung Hoon Kim, In Ho Chang
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Antibody Conjugates for Sarcoma Therapy: How Far along Are We?
Biomedicines, 2021 Sarcomas are one of the most difficult type of cancer to manage and treat because of their extremely heterogeneous molecular and morphological features. Despite the progress made over the years in the establishment of standard protocols for high and low ...
Letizia Polito +5 more
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Synthesized Anti-HER2 Trastuzumab-MCC-DM1 Conjugate: An Evaluation of Efficacy and Cytotoxicity [PDF]
Iranian Journal of Immunology, 2023 Background: Trastuzumab is a humanized monoclonal antibody that targets site-specifically human epidermal growth factor-2 receptor (HER2) cell surface antigen overexpressed in approximately 20% of human breast carcinomas. Despite its positive therapeutic
Soodabeh Shafiee +5 more
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Anti-HIV double variable domain immunoglobulins binding both gp41 and gp120 for targeted delivery of immunoconjugates. [PDF]
PLoS ONE, 2012 BACKGROUND: Anti-HIV immunoconjugates targeted to the HIV envelope protein may be used to eradicate the latent reservoir of HIV infection using activate-and-purge protocols.
Ryan B Craig +3 more
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Immunotherapy with Antibodies in Multiple Myeloma: Monoclonals, Bispecifics, and Immunoconjugates
Hemato, 2021 In the 2010s, immunotherapy revolutionized the treatment landscape of multiple myeloma. CD38-targeting antibodies were initially applied as monotherapy in end-stage patients, but are now also approved by EMA/FDA in combination with standards-of-care in ...
Christie P. M. Verkleij +3 more
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Antibody Conjugates for Targeted Therapy Against HIV-1 as an Emerging Tool for HIV-1 Cure
Frontiers in Immunology, 2021 Although advances in antiretroviral therapy (ART) have significantly improved the life expectancy of people living with HIV-1 (PLWH) by suppressing HIV-1 replication, a cure for HIV/AIDS remains elusive.
Jeffrey C. Umotoy, Steven W. de Taeye
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Comparison of HER2-Targeted Antibodies for Fluorescence-Guided Surgery in Breast Cancer
Molecular Imaging, 2021 Background. Although therapeutic advances have led to enhanced survival in patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer, detection of residual disease remains challenging.
Solmaz AghaAmiri +8 more
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