Results 41 to 50 of about 4,990 (167)
Impaired FADD/BID signaling mediates cross-resistance to immunotherapy in Multiple Myeloma
Communications Biology, 2023 The treatment landscape in multiple myeloma (MM) is shifting from genotoxic drugs to immunotherapies. Monoclonal antibodies, immunoconjugates, T-cell engaging antibodies and CART cells have been incorporated into routine treatment algorithms, resulting ...
Umair Munawar +30 more
doaj +1 more source
Inter‐Nanoparticle FRET for Biosensing: Photophysics Versus Size
Angewandte Chemie International Edition, Volume 64, Issue 39, September 22, 2025.Förster resonance energy transfer (FRET) systems with luminescent nanoparticles (NPs) as donors and acceptors (inter‐NP FRET) combine unique photophysical properties with large sizes. This review discusses the influence of NP type, architecture, surface chemistry, and optical properties on FRET and the pros and cons of inter‐NP FRET for bioanalytical ...
Eduard Madirov +3 more
wiley +1 more source
The Journal of Pathology, Volume 267, Issue 1, Page 69-78, September 2025.Abstract Chondroitin sulfate proteoglycan 4 (CSPG4) is a promising target for melanoma immunotherapy, but its expression in benign melanocytic lesions and its diagnostic value remain unexplored. This study assessed CSPG4 expression in benign nevi (BN), dysplastic nevi (DN), and superficial spreading melanomas (SSM), comparing it with PRAME ...
Elias A T Koch +8 more
wiley +1 more source
ChemElectroChem, 2022 Alzheimer's disease (AD), the most common neurodegenerative disorder, demands new cost‐effective and easy‐to‐use strategies for its reliable detection, mainly in the preclinical stages.
Alejandro Valverde +12 more
doaj +1 more source
Photochemistry and Photobiology, Volume 101, Issue 5, Page 1211-1231, September/October 2025.Through mRNA sequencing, proteomics, and flow cytometry, we identified potential cell surface targets toward tumor‐targeted, activatable photoimmunotherapy (taPIT) in advanced high‐grade serous ovarian cancers (HGSOCs) with low EGFR expression. The reliance on EGFR overexpression has been a major limitation of taPIT, which this study seeks to address ...
Sudip Timilsina +3 more
wiley +1 more source
SYNTHESIS OF 25-HYDROXYVITAMIN D3 CONJUGATE WITH KEYHOLE LIMPET HEMOCYANIN AND OBTAINING OF IMMUNE SERA [PDF]
Biotechnologia Acta, 2015 The study was aimed at obtaining polyclonal antibodies that recognize 25-Hydroxyvitamin D3, for their further specifications and applications in immunochemical test systems of 25-Hydroxyvitamin D3, determination in blood serum.
А. O. Mazanova +5 more
doaj +1 more source
Hematological Oncology, Volume 43, Issue 4, July 2025.ABSTRACT Relapsed/refractory multiple myeloma (RRMM) patients with dialysis‐dependent renal impairment face limited therapeutic options due to exclusion from clinical trials, a lack of evidence‐based guidelines, and inferior outcomes. Bispecific antibodies targeting B‐cell maturation antigen (BCMA) have shown promise in RRMM treatment but remain ...
Michèle Hoffmann +7 more
wiley +1 more source
Journal of Oncological SciencesLarge molecular antibody-drug conjugates (ADCs) are able to easily access the site of metastasis in the brain due to the edematous structure of brain metastases, facilitating considerably high concentrations of the cytotoxic component of these ADCs in ...
Didem DİVRİKLİOĞLU +3 more
doaj +1 more source
Deconstructing the Thymic Microenvironment Through Genesis to Senescence
Immunological Reviews, Volume 332, Issue 1, July 2025.ABSTRACT The thymus is essential for adaptive immunity, orchestrating the differentiation of hematopoietic progenitors into various T‐cell lineages. Thymic epithelial cells (TECs) impart this unique function by mediating the major checkpoints in T‐cell differentiation while also imposing stringent tolerance processes required to prevent autoimmunity ...
Michael D'Andrea +2 more
wiley +1 more source
Evaluation of Radiolabeled Girentuximab In Vitro and In Vivo
Pharmaceuticals, 2018 Girentuximab (cG250) targets carbonic anhydrase IX (CAIX), a protein which is expressed on the surface of most renal cancer cells (RCCs). cG250 labeled with 177Lu has been used in clinical trials for radioimmunotherapy (RIT) of RCCs.
Tais Basaco +10 more
doaj +1 more source