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Primary immunodeficiency [PDF]
Allergy, Asthma & Clinical Immunology, 2018 Primary immunodeficiency disorder (PID) refers to a large heterogeneous group of disorders that result from defects in immune system development and/or function.
C. Mccusker, J. Upton, R. Warrington
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Primary immunodeficiency: common variable immunodeficiency [PDF]
Ķazaķstannyṇ Klinikalyķ Medicinasy, 2016 By definition, primary immunodeficiencies are genetically determined diseases, which are fundamental molecular or organic defects associated with impaired immune responses, in this case there is the clinic of infectious and autoimmune diseases, with an ...
Oksana Ussenova +3 more
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Research on Rare Diseases in Germany – The GAIN Registry: a registry for individuals with congenital multi-organ autoimmune diseases [PDF]
Journal of Health Monitoring, 2023 Background: Patient registries are an important tool for networking medical caregivers and research, especially in the field of rare diseases. Individuals afflicted by multi-organ autoimmune diseases typically suffer from inflammation of multiple organs.
Cynthia Stapornwongkul +10 more
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Frontiers in Immunology, 2021 Predominantly antibody deficiencies (PAD) are a heterogeneous group of disorders characterized by dysfunctional antibody production, low immunoglobulin levels in serum and impaired vaccine responses.
Jessica Rojas-Restrepo +31 more
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From Flies to Men: ROS and the NADPH Oxidase in Phagocytes
Frontiers in Cell and Developmental Biology, 2021 The cellular formation of reactive oxygen species (ROS) represents an evolutionary ancient antimicrobial defense system against microorganisms. The NADPH oxidases (NOX), which are predominantly localized to endosomes, and the electron transport chain in ...
Zohreh Mansoori Moghadam +4 more
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Monocyte progenitors give rise to multinucleated giant cells
Nature Communications, 2021 Multinucleated giant cells characterize granuloma formation in mycobacterial infections. Here the authors identify monocyte precursors with distinct immunological and metabolic properties as a source of the granuloma multinucleated giant cell compartment.
Anne Kathrin Lösslein +18 more
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Scientific Reports, 2022 Inhibitors of histone deacetylases (HDACis) are major latency reversing agent (LRA) candidates in ‘shock and kill’ strategies to eradicate the HIV reservoir in infected patients.
Daniela Angela Covino +2 more
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Intra-Household and Close-Contact SARS-CoV-2 Transmission Among Children – a Systematic Review
Frontiers in Pediatrics, 2021 Introduction: The outbreak of the novel coronavirus disease (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a range of emergency measures worldwide. Early in the pandemic, children were suspected to act as
Benedikt D. Spielberger +7 more
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Jornal de Pediatria, 2021 Inborn Errors of Immunity (IEI), also known as primary immunodeficiencies, correspond to a heterogeneous group of congenital diseases that primarily affect immune response components. The main clinical manifestations comprise increased susceptibility to infections, autoimmunity, inflammation, allergies and malignancies.
Carolina Sanchez Aranda +2 more
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Adoptive T cell therapy cures mice from active hemophagocytic lymphohistiocytosis (HLH)
EMBO Molecular Medicine, 2022 Primary hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome caused by impaired lymphocyte cytotoxicity. First‐line therapeutic regimens directed against activated immune cells or secreted cytokines show limited efficacy since they do
Kristoffer Weißert +7 more
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