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Primary immunodeficiency: common variable immunodeficiency [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy, 2016
By definition, primary immunodeficiencies are genetically determined diseases, which are fundamental molecular or organic defects associated with impaired immune responses, in this case there is the clinic of infectious and autoimmune diseases, with an ...
Oksana Ussenova, Dinara Gabdullina, Marina Morenko, Yelena Kovzel   +3 more
doaj   +2 more sources

Research on Rare Diseases in Germany – The GAIN Registry: a registry for individuals with congenital multi-organ autoimmune diseases [PDF]

Journal of Health Monitoring, 2023
Background: Patient registries are an important tool for networking medical caregivers and research, especially in the field of rare diseases. Individuals afflicted by multi-organ autoimmune diseases typically suffer from inflammation of multiple organs.
Cynthia Stapornwongkul, Alexandra Nieters, Paulina Staus, Stephan Rusch, Anita Delor, Ulrich Baumann, Julius Wehrle, Melanie Boerries, Markus G. Seidel, Bodo Grimbacher, Gerhard Kindle   +10 more
doaj   +1 more source

Germline STAT3 gain-of-function mutations in primary immunodeficiency: Impact on the cellular and clinical phenotype

Biomedical Journal, 2021
Signal transducer and activator of transcription 3 (STAT3) is a key transcription factor involved in regulation of immune cell activation and differentiation.
Laura Faletti, Stephan Ehl, Maximilian Heeg   +2 more
doaj   +1 more source

Establishing the Molecular Diagnoses in a Cohort of 291 Patients With Predominantly Antibody Deficiency by Targeted Next-Generation Sequencing: Experience From a Monocentric Study

Frontiers in Immunology, 2021
Predominantly antibody deficiencies (PAD) are a heterogeneous group of disorders characterized by dysfunctional antibody production, low immunoglobulin levels in serum and impaired vaccine responses.
Jessica Rojas-Restrepo, Jessica Rojas-Restrepo, Jessica Rojas-Restrepo, Andrés Caballero-Oteyza, Andrés Caballero-Oteyza, Andrés Caballero-Oteyza, Katrin Huebscher, Katrin Huebscher, Hanna Haberstroh, Hanna Haberstroh, Manfred Fliegauf, Manfred Fliegauf, Manfred Fliegauf, Baerbel Keller, Baerbel Keller, Baerbel Keller, Robin Kobbe, Klaus Warnatz, Klaus Warnatz, Klaus Warnatz, Stephan Ehl, Stephan Ehl, Michele Proietti, Michele Proietti, Michele Proietti, Michele Proietti, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher   +31 more
doaj   +1 more source

Normalization of Negative Stigma Against HIV/AIDS Patients: A Systematic Review of the Literature [PDF]

, 2023
Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS) is a public health problem that stigmatizes its victims. Mental attacks, as a result of labeling and discrimination, result in psychological suffering and well-being for persons
Machmud, Muslimin, Salahudin, Salahudin, Sutanto, M. Himawan   +2 more
core   +1 more source

From Flies to Men: ROS and the NADPH Oxidase in Phagocytes

Frontiers in Cell and Developmental Biology, 2021
The cellular formation of reactive oxygen species (ROS) represents an evolutionary ancient antimicrobial defense system against microorganisms. The NADPH oxidases (NOX), which are predominantly localized to endosomes, and the electron transport chain in ...
Zohreh Mansoori Moghadam, Zohreh Mansoori Moghadam, Philipp Henneke, Philipp Henneke, Julia Kolter   +4 more
doaj   +1 more source

Monocyte progenitors give rise to multinucleated giant cells

Nature Communications, 2021
Multinucleated giant cells characterize granuloma formation in mycobacterial infections. Here the authors identify monocyte precursors with distinct immunological and metabolic properties as a source of the granuloma multinucleated giant cell compartment.
Anne Kathrin Lösslein, Florens Lohrmann, Lisa Scheuermann, Kourosh Gharun, Jana Neuber, Julia Kolter, Aaron James Forde, Christian Kleimeyer, Ying Yee Poh, Matthias Mack, Antigoni Triantafyllopoulou, Micah D. Dunlap, Shabaana A. Khader, Maximilian Seidl, Alexandra Hölscher, Christoph Hölscher, Xue Li Guan, Anca Dorhoi, Philipp Henneke   +18 more
doaj   +1 more source

Impact of IL-15 and latency reversing agent combinations in the reactivation and NK cell-mediated suppression of the HIV reservoir

Scientific Reports, 2022
Inhibitors of histone deacetylases (HDACis) are major latency reversing agent (LRA) candidates in ‘shock and kill’ strategies to eradicate the HIV reservoir in infected patients.
Daniela Angela Covino, Maria Giovanna Desimio, Margherita Doria   +2 more
doaj   +1 more source

Intra-Household and Close-Contact SARS-CoV-2 Transmission Among Children – a Systematic Review

Frontiers in Pediatrics, 2021
Introduction: The outbreak of the novel coronavirus disease (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a range of emergency measures worldwide. Early in the pandemic, children were suspected to act as
Benedikt D. Spielberger, Tessa Goerne, Tessa Goerne, Anne Geweniger, Philipp Henneke, Philipp Henneke, Roland Elling, Roland Elling   +7 more
doaj   +1 more source

Adoptive T cell therapy cures mice from active hemophagocytic lymphohistiocytosis (HLH)

EMBO Molecular Medicine, 2022
Primary hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome caused by impaired lymphocyte cytotoxicity. First‐line therapeutic regimens directed against activated immune cells or secreted cytokines show limited efficacy since they do
Kristoffer Weißert, Sandra Ammann, Tamara Kögl, Viviane Dettmer‐Monaco, Christoph Schell, Toni Cathomen, Stephan Ehl, Peter Aichele   +7 more
doaj   +1 more source