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Primary immunodeficiency [PDF]
Allergy, Asthma & Clinical Immunology, 2018 Primary immunodeficiency disorder (PID) refers to a large heterogeneous group of disorders that result from defects in immune system development and/or function. PIDs are broadly classified as disorders of adaptive immunity (i.e., T cell, B-cell or combined immunodeficiencies) or of innate immunity (e.g., phagocyte and complement disorders).
C. Mccusker, J. Upton, R. Warrington
semanticscholar +5 more sources
Jornal de Pediatria, 2021 Inborn Errors of Immunity (IEI), also known as primary immunodeficiencies, correspond to a heterogeneous group of congenital diseases that primarily affect immune response components. The main clinical manifestations comprise increased susceptibility to infections, autoimmunity, inflammation, allergies and malignancies.
Carolina Sanchez Aranda +2 more
openaire +5 more sources
A Quantitative Analysis of Dynamic Mechanisms Regulating HIV Latency and Activation [PDF]
Prog. Biochem. Biophys. 2023,50(2):385-396, 2022 Objective: The reservoir of human immunodeficiency virus (HIV) latently infected cells is the major obstacle for eradication of acquired immunodeficiency syndrome (AIDS). Due to the noisy environment and multiple influencing factors in the organism, current dynamical models cannot reach a common understanding of the molecular mechanism of HIV latency ...
arxiv +1 more source
Primary immunodeficiency [PDF]
Allergy, Asthma & Clinical Immunology, 2011 Primary immunodeficiency disorder (PID) refers to a heterogeneous group of over 130 disorders that result from defects in immune system development and/or function. PIDs are broadly classified as disorders of adaptive immunity (i.e., T-cell, B-cell or combined immunodeficiencies) or of innate immunity (e.g., phagocyte and complement disorders ...
Christine McCusker, Richard Warrington
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New England Journal of Medicine, 1998 To the Editor: Palella et al. (March 26 issue)1 reported that the use of more intensive antiretroviral therapies is responsible for declines in both morbidity and mortality in patients with AIDS.
S. Michaels, R. Clark, P. Kissinger
semanticscholar +1 more source
Clinical and Experimental Immunology, 2009 SummaryPrimary immunodeficiencies (PIDs) are uncommon, chronic and severe disorders of the immune system in which patients cannot mount a sufficiently protective immune response, leading to an increased susceptibility to infections. The treatment of choice for PID patients with predominant antibody deficiency is intravenous immunoglobulin (Ig ...
Ballow, Mark +11 more
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New England Journal of Medicine, 1998 BACKGROUND AND METHODS National surveillance data show recent, marked reductions in morbidity and mortality associated with the acquired immunodeficiency syndrome (AIDS).
F. Palella +7 more
semanticscholar +1 more source
Journal of Virology, 1986 We constructed an infectious molecular clone of acquired immunodeficiency syndrome-associated retrovirus. Upon transfection, this clone directed the production of infectious virus particles in a wide variety of cells in addition to human T4 cells.
Akio Adachi +6 more
semanticscholar +1 more source
Autoimmunity in Immunodeficiency [PDF]
Current Allergy and Asthma Reports, 2013 Primary immunodeficiencies (PID) comprise a diverse group of clinical disorders with varied genetic defects. Paradoxically, a substantial proportion of PID patients develop autoimmune phenomena in addition to having increased susceptibility to infections from their impaired immunity.
Teresa K. Tarrant +3 more
openaire +3 more sources
Journal of Virology, 1994 Virologic and immunologic studies were performed on five patients presenting with primary human immunodeficiency virus type 1 (HIV-1) infection. CD8+ cytotoxic T lymphocyte (CTL) precursors specific for cells expressing antigens of HIV-1 Gag, Pol, and ...
R. Koup +7 more
semanticscholar +1 more source