Results 21 to 30 of about 614,575 (264)

Adoptive T cell therapy cures mice from active hemophagocytic lymphohistiocytosis (HLH)

EMBO Molecular Medicine, 2022
Primary hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome caused by impaired lymphocyte cytotoxicity. First‐line therapeutic regimens directed against activated immune cells or secreted cytokines show limited efficacy since they do
Kristoffer Weißert, Sandra Ammann, Tamara Kögl, Viviane Dettmer‐Monaco, Christoph Schell, Toni Cathomen, Stephan Ehl, Peter Aichele   +7 more
doaj   +1 more source

Resident macrophages acquire innate immune memory in staphylococcal skin infection

eLife, 2020
Staphylococcus aureus (S. aureus) is a common colonizer of healthy skin and mucous membranes. At the same time, S. aureus is the most frequent cause of skin and soft tissue infections.
Reinhild Feuerstein, Aaron James Forde, Florens Lohrmann, Julia Kolter, Neftali Jose Ramirez, Jakob Zimmermann, Mercedes Gomez de Agüero, Philipp Henneke   +7 more
doaj   +1 more source

Primary immunodeficiency [PDF]

Allergy, Asthma & Clinical Immunology, 2011
Primary immunodeficiency disorder (PID) refers to a heterogeneous group of over 130 disorders that result from defects in immune system development and/or function. PIDs are broadly classified as disorders of adaptive immunity (i.e., T-cell, B-cell or combined immunodeficiencies) or of innate immunity (e.g., phagocyte and complement disorders ...
Christine McCusker, Richard Warrington
openaire   +4 more sources

CD160 Promotes NK Cell Functions by Upregulating Glucose Metabolism and Negatively Correlates With HIV Disease Progression

Frontiers in Immunology, 2022
Natural killer (NK) cells are crucial for immune responses to viral infections. CD160 is an important NK cell activating receptor, with unknown function in HIV infection.
Zheng Sun, Zheng Sun, Zheng Sun, Yidi Li, Yidi Li, Yidi Li, Zining Zhang, Zining Zhang, Zining Zhang, Yajing Fu, Yajing Fu, Yajing Fu, Xiaoxu Han, Xiaoxu Han, Xiaoxu Han, Qinghai Hu, Qinghai Hu, Qinghai Hu, Haibo Ding, Haibo Ding, Haibo Ding, Hong Shang, Hong Shang, Hong Shang, Hong Shang, Yongjun Jiang, Yongjun Jiang, Yongjun Jiang   +27 more
doaj   +1 more source

Recurrent Vulvovaginal Candidiasis: Could It Be Related to Cell-Mediated Immunity Defect in Response to Candida Antigen? [PDF]

International Journal of Fertility and Sterility, 2017
Background Recurrent vulvovaginal candidiasis (RVVC) is a common cause of morbidity affecting millions of women worldwide. Patients with RVVC are thought to have an underlying immunologic defect.
Zahra Talaei, Saba Sheikhbahaei, Vajihe Ostadi, Mazdak Ganjalikhani Hakemi, Mohsen Meidani, Elham Naghshineh, Majid Yaran, Alireza Emami Naeini, Roya Sherkat   +8 more
doaj   +1 more source

Immunodeficiencies

Clinical and Experimental Immunology, 2009
SummaryPrimary immunodeficiencies (PIDs) are uncommon, chronic and severe disorders of the immune system in which patients cannot mount a sufficiently protective immune response, leading to an increased susceptibility to infections. The treatment of choice for PID patients with predominant antibody deficiency is intravenous immunoglobulin (Ig ...
Ballow, Mark, Notarangelo, Luigi, Grimbacher, Bodo, Cunningham-Rundles, Charlotte, Stein, Mark R., Helbert, Matthew, Gathmann, Benjamin, Kindle, G., Knight, A. K., Ochs, Hans D., Sullivan, Kathleen E., Franco, José Luis   +11 more
openaire   +6 more sources

Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection.

New England Journal of Medicine, 1998
To the Editor: Palella et al. (March 26 issue)1 reported that the use of more intensive antiretroviral therapies is responsible for declines in both morbidity and mortality in patients with AIDS.
S. Michaels, R. Clark, P. Kissinger
semanticscholar   +1 more source

Autoimmunity in Immunodeficiency [PDF]

Current Allergy and Asthma Reports, 2013
Primary immunodeficiencies (PID) comprise a diverse group of clinical disorders with varied genetic defects. Paradoxically, a substantial proportion of PID patients develop autoimmune phenomena in addition to having increased susceptibility to infections from their impaired immunity.
Teresa K. Tarrant, Krista Todoric, Jessica Koontz, Daniel E Mattox   +3 more
openaire   +3 more sources

Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators.

New England Journal of Medicine, 1998
BACKGROUND AND METHODS National surveillance data show recent, marked reductions in morbidity and mortality associated with the acquired immunodeficiency syndrome (AIDS).
F. Palella, K. Delaney, A. Moorman, M. Loveless, J. Fuhrer, G. Satten, D. Aschman, S. Holmberg   +7 more
semanticscholar   +1 more source

Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

Journal of Virology, 1986
We constructed an infectious molecular clone of acquired immunodeficiency syndrome-associated retrovirus. Upon transfection, this clone directed the production of infectious virus particles in a wide variety of cells in addition to human T4 cells.
Akio Adachi, H. Gendelman, Scott Koenig, T. M. Folks, R. Willey, A. B. Rabson, M. A. Martin   +6 more
semanticscholar   +1 more source