Results 31 to 40 of about 863,721 (336)

Assessing the Functional Relevance of Variants in the IKAROS Family Zinc Finger Protein 1 (IKZF1) in a Cohort of Patients With Primary Immunodeficiency

Frontiers in Immunology, 2019
Common variable immunodeficiency (CVID) is the most frequent symptomatic primary immunodeficiency. Patients with CVID are prone to recurrent bacterial infection due to the failure of adequate immunoglobulin production.
Zoya Eskandarian, Zoya Eskandarian, Manfred Fliegauf, Manfred Fliegauf, Alla Bulashevska, Michele Proietti, Rosie Hague, Cristian Roberto Smulski, Desirée Schubert, Klaus Warnatz, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher   +14 more
doaj   +1 more source

Cytomegaloviruses and Macrophages—Friends and Foes From Early on?

Frontiers in Immunology, 2020
Starting at birth, newborn infants are exposed to numerous microorganisms. Adaptation of the innate immune system to them is a delicate process, with potentially advantageous and harmful implications for health development.
Sebastian Baasch, Sebastian Baasch, Zsolt Ruzsics, Philipp Henneke, Philipp Henneke   +4 more
doaj   +1 more source

Case Report: Hemophagocytic Lymphohistiocytosis and Non-Tuberculous Mycobacteriosis Caused by a Novel GATA2 Variant

Frontiers in Immunology, 2021
Hemophagocytic lymphohistiocytosis (HLH) is a disorder of uncontrolled immune activation with distinct clinical features including fever, cytopenia, splenomegaly, and sepsis-like symptoms.
Thomas Mika, Deepak Vangala, Matthias Eckhardt, Paul La Rosée, Christoph Lange, Christoph Lange, Kai Lehmberg, Charlotte Wohlschläger, Saskia Biskup, Ilka Fuchs, Jasmin Mann, Stephan Ehl, Klaus Warnatz, Klaus Warnatz, Roland Schroers   +14 more
doaj   +1 more source

Subcutaneous IgG Replacement Therapy by Push in 32 Patients with Primary Immunodeficiency Diseases in Argentine [PDF]

, 2014
Introduction: Regular replacement with immunoglobulin infusions is the mainstay of treatment in the majority of primary immunodeficiencies. Several studies showed that Subcutaneous Immunoglobulin (SCIG) has similar efficacy to Intravenous Immunoglobulin (
Bezrodnik, Liliana, Díaz Ballve, Damacia, Giovanni, Daniela Di, Gómez Raccio, Andrea, Moreira, Ileana, Regairaz, Lorena, Seminario, Gisela   +6 more
core   +1 more source

Dimerisation of HIV-2 genomic RNA is linked to efficient RNA packaging, normal particle maturation and viral infectivity. [PDF]

, 2007
BACKGROUND: Retroviruses selectively encapsidate two copies of their genomic RNA, the Gag protein binding a specific RNA motif in the 5' UTR of the genome.
Andrew ML Lever (60785), Anne L'Hernault (60782), Jane S Greatorex (60783), R Anthony Crowther (60784)   +3 more
core   +3 more sources

A mutation in caspase-9 decreases the expression of BAFFR and ICOS in patients with immunodeficiency and lymphoproliferation [PDF]

, 2015
Lymphocyte apoptosis is mainly induced by either death receptor-dependent activation of caspase-8 or mitochondria-dependent activation of caspase-9. Mutations in caspase-8 lead to autoimmunity/lymphoproliferation and immunodeficiency. This work describes
Boggio, E, Cappellano, G, Chiocchetti, A., Clemente, N, Dianzani, C, Dianzani, I, Dianzani, U, Gigliotti, Cl, Notarangelo, Ld, Orilieri, E, Pignata, C, Quinti, Isabella, Ramenghi, U, Santoro, C, Toth, E, Valletti, Pa   +15 more
core   +2 more sources

Molecular changes associated with increased TNF-α-induced apoptotis in naïve (TN) and central memory (TCM) CD8+ T cells in aged humans

Immunity & Ageing, 2018
Background Progressive T cell decline in aged humans is associated with a deficiency of naïve (TN) and central memory (TCM) T cells. We have previously reported increased Tumor necrosis factor-α (TNF-α)-induced apoptosis in TN and TCM T cells in aged ...
Sudhir Gupta, Houfen Su, Sudhanshu Agrawal, Sastry Gollapudi   +3 more
doaj   +1 more source

Altered Microbiota, Impaired Quality of Life, Malabsorption, Infection, and Inflammation in CVID Patients With Diarrhoea

Frontiers in Immunology, 2020
Background: Diarrhoea is the commonest gastrointestinal symptom in patients with common variable immunodeficiency (CVID).Objective: The aim of this study was to describe the prevalence and clinical presentation of chronic and recurrent diarrhoea in the ...
Cornelia M. van Schewick, Cornelia M. van Schewick, Christina Nöltner, Svenja Abel, Svenja Abel, Siobhan O. Burns, Sarita Workman, Andrew Symes, David Guzman, Michele Proietti, Alla Bulashevska, Fernando Moreira, Veronika Soetedjo, David M. Lowe, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher   +18 more
doaj   +1 more source

Limited effectiveness of high-dose liposomal amphotericin B (AmBisome) for treatment of visceral leishmaniasis in an Ethiopian population with high HIV prevalence. [PDF]

, 2011
Due to unacceptably high mortality with pentavalent antimonials, Médecins Sans Frontières in 2006 began using liposomal amphotericin B (AmBisome) for visceral leishmaniasis (VL) patients in Ethiopia who were severely ill or positive for human ...
Aderie, Endashaw Mengistu, Chane, Solomon, Collin, Simon M, Davidson, Robert N, Piening, Turid, Ritmeijer, Koert, ter Horst, Rachel   +6 more
core   +2 more sources

Modeling MyD88 Deficiency In Vitro Provides New Insights in Its Function

Frontiers in Immunology, 2020
Inherited defects in MyD88 and IRAK4, two regulators in Toll-like receptor (TLR) signaling, are clinically highly relevant, but still incompletely understood.
Nils Craig-Mueller, Nils Craig-Mueller, Nils Craig-Mueller, Ruba Hammad, Ruba Hammad, Ruba Hammad, Roland Elling, Roland Elling, Roland Elling, Jamal Alzubi, Jamal Alzubi, Barbara Timm, Barbara Timm, Julia Kolter, Julia Kolter, Nele Knelangen, Nele Knelangen, Christien Bednarski, Christien Bednarski, Birgitta Gläser, Sandra Ammann, Sandra Ammann, Zoltán Ivics, Judith Fischer, Judith Fischer, Carsten Speckmann, Carsten Speckmann, Carsten Speckmann, Klaus Schwarz, Nico Lachmann, Nico Lachmann, Stephan Ehl, Stephan Ehl, Stephan Ehl, Thomas Moritz, Thomas Moritz, Philipp Henneke, Philipp Henneke, Philipp Henneke, Philipp Henneke, Toni Cathomen, Toni Cathomen, Toni Cathomen   +42 more
doaj   +1 more source