Results 31 to 40 of about 614,575 (264)

Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome

Journal of Virology, 1994
Virologic and immunologic studies were performed on five patients presenting with primary human immunodeficiency virus type 1 (HIV-1) infection. CD8+ cytotoxic T lymphocyte (CTL) precursors specific for cells expressing antigens of HIV-1 Gag, Pol, and ...
R. Koup, J. Safrit, Yun-zhen Cao, C. Andrews, G. McLeod, W. Borkowsky, C. Farthing, D. Ho   +7 more
semanticscholar   +1 more source

Germline STAT3 gain-of-function mutations in primary immunodeficiency: Impact on the cellular and clinical phenotype

Biomedical Journal, 2021
Signal transducer and activator of transcription 3 (STAT3) is a key transcription factor involved in regulation of immune cell activation and differentiation.
Laura Faletti, Stephan Ehl, Maximilian Heeg   +2 more
doaj  

Mutation of Mycobacterium tuberculosis and Implications for Using Whole-Genome Sequencing for Investigating Recent Tuberculosis Transmission

Frontiers in Public Health, 2022
Tuberculosis (TB) control programs use whole-genome sequencing (WGS) of Mycobacterium tuberculosis (Mtb) for detecting and investigating TB case clusters. Existence of few genomic differences between Mtb isolates might indicate TB cases are the result of
Kristin N. Nelson, Sarah Talarico, Shameer Poonja, Clinton J. McDaniel, Martin Cilnis, Alicia H. Chang, Kala Raz, Wendy S. Noboa, Lauren Cowan, Tambi Shaw, James Posey, Benjamin J. Silk   +11 more
doaj   +1 more source

Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group.

New England Journal of Medicine, 2000
BACKGROUND AND METHODS We examined the influence of viral load in relation to other risk factors for the heterosexual transmission of human immunodeficiency virus type 1 (HIV-1). In a community-based study of 15,127 persons in a rural district of Uganda,
T. Quinn, M. Wawer, N. Sewankambo, D. Serwadda, Chuanjun Li, Fredrick Wabwire‐Mangen, M. Meehan, T. Lutalo, Ronald H. Gray   +8 more
semanticscholar   +1 more source

Sexually transmitted infections and viral hepatitides in patients presenting for non-occupational HIV post-exposure prophylaxis: results of a prospective cohort study

International Journal of Infectious Diseases, 2015
Data evaluating the screening practices for viral hepatitides and sexually transmitted infections (STIs) in patients presenting for non-occupational HIV post-exposure prophylaxis (nPEP) care are limited.
Nirojini Sivachandran, Reed A.C. Siemieniuk, Pauline Murphy, Andrea Sharp, Christine Walach, Tania Placido, Isaac I. Bogoch   +6 more
doaj   +1 more source

A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team.

New England Journal of Medicine, 1997
BACKGROUND The efficacy and safety of adding a protease inhibitor to two nucleoside analogues to treat human immunodeficiency virus type 1 (HIV-1) infection are not clear.
S. Hammer, Kathleen Squires, M. Hughes, Michael Hughes, J. Grimes, L. Demeter, J. Currier, J. Eron, J. Feinberg, H. Balfour, L. Deyton, J. Chodakewitz, M. Fischl, J. Phair, W. Spreen, L. Pedneault, B. Nguyen, Jon C. Cook   +17 more
semanticscholar   +1 more source

International Union of Immunological Societies: 2017 Primary Immunodeficiency Diseases Committee Report on Inborn Errors of Immunity

Journal of Clinical Immunology, 2017
Beginning in 1970, a committee was constituted under the auspices of the World Health Organization (WHO) to catalog primary immunodeficiencies. Twenty years later, the International Union of Immunological Societies (IUIS) took the remit of this committee.
Capucine Picard, H. B. Gaspar, W. Al-Herz, A. Bousfiha, J. Casanova, Talal A Chatila, Y. Crow, Y. Crow, C. Cunningham-Rundles, A. Etzioni, J. Franco, Steven M. Holland, Christoph Klein, Tomohiro Morio, Hans D. Ochs, Eric Oksenhendler, J. Puck, M. Tang, M. Tang, S. Tangye, S. Tangye, T. Torgerson, Kathleen E. Sullivan   +22 more
semanticscholar   +1 more source

Assessing the Functional Relevance of Variants in the IKAROS Family Zinc Finger Protein 1 (IKZF1) in a Cohort of Patients With Primary Immunodeficiency

Frontiers in Immunology, 2019
Common variable immunodeficiency (CVID) is the most frequent symptomatic primary immunodeficiency. Patients with CVID are prone to recurrent bacterial infection due to the failure of adequate immunoglobulin production.
Zoya Eskandarian, Zoya Eskandarian, Manfred Fliegauf, Manfred Fliegauf, Alla Bulashevska, Michele Proietti, Rosie Hague, Cristian Roberto Smulski, Desirée Schubert, Klaus Warnatz, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher   +14 more
doaj   +1 more source

Case Report: Hemophagocytic Lymphohistiocytosis and Non-Tuberculous Mycobacteriosis Caused by a Novel GATA2 Variant

Frontiers in Immunology, 2021
Hemophagocytic lymphohistiocytosis (HLH) is a disorder of uncontrolled immune activation with distinct clinical features including fever, cytopenia, splenomegaly, and sepsis-like symptoms.
Thomas Mika, Deepak Vangala, Matthias Eckhardt, Paul La Rosée, Christoph Lange, Christoph Lange, Kai Lehmberg, Charlotte Wohlschläger, Saskia Biskup, Ilka Fuchs, Jasmin Mann, Stephan Ehl, Klaus Warnatz, Klaus Warnatz, Roland Schroers   +14 more
doaj   +1 more source

Cytomegaloviruses and Macrophages—Friends and Foes From Early on?

Frontiers in Immunology, 2020
Starting at birth, newborn infants are exposed to numerous microorganisms. Adaptation of the innate immune system to them is a delicate process, with potentially advantageous and harmful implications for health development.
Sebastian Baasch, Sebastian Baasch, Zsolt Ruzsics, Philipp Henneke, Philipp Henneke   +4 more
doaj   +1 more source