Cytomegaloviruses and Macrophages—Friends and Foes From Early on?
Frontiers in Immunology, 2020 Starting at birth, newborn infants are exposed to numerous microorganisms. Adaptation of the innate immune system to them is a delicate process, with potentially advantageous and harmful implications for health development.
Sebastian Baasch +4 more
doaj +1 more source
Characterization of a novel type of HIV-1 particle assembly inhibitor using a quantitative Luciferase-Vpr packaging-based assay [PDF]
, 2011 The HIV-1 auxiliary protein Vpr and Vpr-fusion proteins can be copackaged with Gag precursor (Pr55Gag) into virions or membrane-enveloped virus-like particles (VLP).
Elisabeth Errazuriz +9 more
core +9 more sources
Immunity & Ageing, 2018 Background Progressive T cell decline in aged humans is associated with a deficiency of naïve (TN) and central memory (TCM) T cells. We have previously reported increased Tumor necrosis factor-α (TNF-α)-induced apoptosis in TN and TCM T cells in aged ...
Sudhir Gupta +3 more
doaj +1 more source
Diagnosis of childhood tuberculosis and host RNA expression in Africa [PDF]
, 2014 Improved diagnostic tests for tuberculosis in children are needed. We hypothesized that transcriptional signatures of host blood could be used to distinguish tuberculosis from other diseases in African children who either were or were not infected with ...
Amelia C. Crampin +26 more
core +5 more sources
Frontiers in Immunology, 2020 Background: Diarrhoea is the commonest gastrointestinal symptom in patients with common variable immunodeficiency (CVID).Objective: The aim of this study was to describe the prevalence and clinical presentation of chronic and recurrent diarrhoea in the ...
Cornelia M. van Schewick +18 more
doaj +1 more source
altered expression of cD300a inhibitory receptor on cD4+ T cells From human immunodeficiency Virus-1-infected Patients: association With Disease Progression Markers. [PDF]
, 2018 The ability of the CD300a inhibitory receptor to modulate immune cell functions and its involvement in the pathogenesis of many diseases has aroused a great interest in this molecule.
Genebat González, Miguel +3 more
core +1 more source
Divergent Annexin A1 expression in periphery and gut is associated with systemic immune activation and impaired gut immune response during SIV infection. [PDF]
, 2016 HIV-1 disease progression is paradoxically characterized by systemic chronic immune activation and gut mucosal immune dysfunction, which is not fully defined.
Dandekar, Satya +6 more
core +1 more source
BMC Pregnancy and Childbirth, 2018 Background Patients with primary immunodeficiency disease (PID) who survive to adulthood and willing to have a child mostly are worried whether their disease affects their fertility and/or pregnancy and also if their child would be predisposed to PID ...
Saba Sheikhbahaei +8 more
doaj +1 more source
Modeling MyD88 Deficiency In Vitro Provides New Insights in Its Function
Frontiers in Immunology, 2020 Inherited defects in MyD88 and IRAK4, two regulators in Toll-like receptor (TLR) signaling, are clinically highly relevant, but still incompletely understood.
Nils Craig-Mueller +42 more
doaj +1 more source
COVID-19 in a patient with Good's syndrome and in 13 patients with common variable immunodeficiency
Clinical Immunology Communications, 2021 Antibody deficiencies constitute the majority of primary immunodeficiencies in adults. These patients have a well-established increased risk of bacterial infections but there is a lack of knowledge regarding the relative risks upon contracting COVID-19 ...
Hannes Lindahl +2 more
doaj +1 more source