Results 41 to 50 of about 874,843 (291)

Obesity and risk of respiratory tract infections: results of an infection-diary based cohort study

BMC Public Health, 2018
Background Respiratory tract infections (RTIs) are a major morbidity factor contributing largely to health care costs and individual quality of life. The aim of the study was to test whether obesity (BMI ≥ 30 kg/m2) is one of the risk factors underlying ...
Livia Maccioni, Susanne Weber, Magdeldin Elgizouli, Anne-Sophie Stoehlker, Ilona Geist, Hans-Hartmut Peter, Werner Vach, Alexandra Nieters   +7 more
doaj   +1 more source

Cluster analysis of flowcytometric immunophenotyping with extended T cell subsets in suspected immunodeficiency

Immunity, Inflammation and Disease, 2023
Background Patients with immunodeficiencies commonly experience diagnostic delays resulting in morbidity. There is an unmet need to identify patients earlier, especially those with high risk for complications.
Luca Seitz, Daniel Gaitan, Caroline M. Berkemeier, Christoph T. Berger, Mike Recher   +4 more
doaj   +1 more source

Mindfulness-Based Intervention For Nurses In AIDS Care In China: A Pilot Study. [PDF]

, 2019
Background/purpose:Workplace stress among nurses providing care for people living with human immunodeficiency virus is a serious problem in China that may increase rates of job burnout and affect quality of care.
Cai, Yu, Chen, Minzhen, Koniak-Griffin, Deborah, Pan, Chen, Tang, Qiuping, Wang, Honghong, Xiao, Changgen   +6 more
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Analysis of multiply spliced transcripts in lymphoid tissue reservoirs of rhesus macaques infected with RT-SHIV during HAART. [PDF]

, 2014
Highly active antiretroviral therapy (HAART) can reduce levels of human immunodeficiency virus type 1 (HIV-1) to undetectable levels in infected individuals, but the virus is not eradicated.
Adamson, Lourdes, Cannavo, Elda, Deere, Jesse D, Higgins, Joanne, Kauffman, Robert C, Luciw, Paul A, North, Thomas W, Schinazi, Raymond F, Villalobos, Andradi   +8 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Entry into the lytic cycle exposes EBV-infected cells to NK cell killing via upregulation of the MICB ligand for NKG2D and activation of the CD56bright and NKG2A+KIR+CD56dim subsets

Frontiers in Immunology
The Epstein–Barr virus (EBV) is usually acquired during infancy as an asymptomatic infection and persists throughout life in a latent state under the control of the host immune system.
Maria Giovanna Desimio, Daniela Angela Covino, Caterina Cancrini, Caterina Cancrini, Margherita Doria   +4 more
doaj   +1 more source

The ABACHAI clinical trial protocol: Safety and efficacy of abatacept (s.c.) in patients with CTLA-4 insufficiency or LRBA deficiency: A non controlled phase 2 clinical trial

Contemporary Clinical Trials Communications, 2022
Background: Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) insufficiency and lipopolysaccharide-responsive and beige-like anchor protein (LRBA) deficiency are both complex immune dysregulation syndromes with an underlying regulatory T cell ...
Máté Krausz, Annette Uhlmann, Ina Caroline Rump, Gabriele Ihorst, Sigune Goldacker, Georgios Sogkas, Sara Posadas-Cantera, Reinhold Schmidt, Manuel Feißt, Laia Alsina, Ingunn Dybedal, Mike Recher, Klaus Warnatz, Bodo Grimbacher   +13 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Immunogens and Antigen Processing: Report from a Global HIV Vaccine Enterprise Working Group [PDF]

, 2010
The Global HIV Vaccine Enterprise convened a meeting of a Working Group in July 2009 to discuss recent progress in rational design of the components of an HIV vaccine, such as inserts, vectors and adjuvants,and in understanding antigen processing and ...
John Mascola, Ralph Steinman, Richter C. King, the Working Group convened by the Global HIV Vaccine Enterprise   +3 more
core   +3 more sources