Results 41 to 50 of about 614,575 (264)

Impact of rare and common genetic variation in the interleukin-1 pathway on human cytokine responses

open access: yesGenome Medicine, 2021
Background The interleukin (IL)-1 pathway is primarily associated with innate immunological defense and plays a major role in the induction and regulation of inflammation.
Rosanne C. van Deuren   +13 more
doaj   +1 more source

Immunodeficiency and the gut

open access: yesMedicine, 2003
Gastrointestinal diseases associated with impaired immunity are largely infectious, although an increased incidence of extranodal lymphoma is also found in the context of HIV infection. The range of such infections is related to the role of CD4-positive T cells in their eradication. Infections tend to occur with organisms of limited virulence and to be
openaire   +2 more sources

Dramatic Rise in Plasma Viremia after CD8+ T Cell Depletion in Simian Immunodeficiency Virus–infected Macaques

open access: yesJournal of Experimental Medicine, 1999
To determine the role of CD8+ T cells in controlling simian immunodeficiency virus (SIV) replication in vivo, we examined the effect of depleting this cell population using an anti-CD8 monoclonal antibody, OKT8F. There was on average a 99.9% reduction of
Xia Jin   +13 more
semanticscholar   +1 more source

Entry into the lytic cycle exposes EBV-infected cells to NK cell killing via upregulation of the MICB ligand for NKG2D and activation of the CD56bright and NKG2A+KIR+CD56dim subsets

open access: yesFrontiers in Immunology
The Epstein–Barr virus (EBV) is usually acquired during infancy as an asymptomatic infection and persists throughout life in a latent state under the control of the host immune system.
Maria Giovanna Desimio   +4 more
doaj   +1 more source

Transplantation Outcomes for Severe Combined Immunodeficiency 2000–2009

open access: yesPediatrics, 2015
SY Pai, BR Logan, LM Griffith. N Engl J Med. 2014;371(5):434–446 To evaluate the outcome of hematopoietic stem cell transplantation (HSCT) in patients with severe combined immunodeficiency (SCID) treated in North America between 2000 and 2009 based on ...
T. Fleisher
semanticscholar   +1 more source

Impact of Primary Immunodeficiency Diseases on the Life Experiences of Patients in Malaysia From the Caregivers’ Perspective: A Qualitative Study

open access: yesFrontiers in Pediatrics, 2022
IntroductionPrimary immunodeficiency diseases (PIDs) are chronic diseases that affect the various aspects of a patient’s life. However, the impact of living with PIDs is poorly described.ObjectiveThis study aimed to explore the living experience ...
Ruwaydah Ahmed Meelad   +10 more
doaj   +1 more source

Autoinflammation and immunodeficiency [PDF]

open access: yesPediatric Rheumatology, 2014
Autoinflammatory diseases are characterized by more or less spontaneous inflammation without inciting infection or autoimmunity. These can be either acquired or genetically determined. The latter –hereditary– autoinflammatory syndromes have been classified by some as primary immunodeficiencies: defects affecting the control of the innate arm of the ...
openaire   +2 more sources

Multi-omics analysis of naïve B cells of patients harboring the C104R mutation in TACI

open access: yesFrontiers in Immunology, 2022
Common variable immunodeficiency (CVID) is the most prevalent form of symptomatic primary immunodeficiency in humans. The genetic cause of CVID is still unknown in about 70% of cases. Ten percent of CVID patients carry heterozygous mutations in the tumor
Neftali Ramirez   +29 more
doaj   +1 more source

Immunodeficiency-associated lymphoproliferative disorders: time for reappraisal?

open access: yesBlood, 2018
Immunodeficiency-associated lymphoproliferative disorders (IA-LPDs) are pathologically and clinically heterogeneous. In many instances, similar features are shared by a spectrum of IA-LPDs in clinically diverse settings.
Y. Natkunam   +7 more
semanticscholar   +1 more source

Immune checkpoint deficiencies and autoimmune lymphoproliferative syndromes

open access: yesBiomedical Journal, 2021
Autoimmune lymphoproliferative syndrome (ALPS) is an inherited non-malignant and non-infectious lymphoproliferative syndrome caused by mutations in genes affecting the extrinsic apoptotic pathway (FAS, FASL, CASP10).
Laura Gámez-Díaz, Bodo Grimbacher
doaj  

Home - About - Disclaimer - Privacy