Results 61 to 70 of about 14,210 (195)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Sequence diversity within a subgroup of mouse immunoglobulin kappa chains controlled by the IgK-Ef2 locus. [PDF]

The Journal of experimental medicine, 1981
We previously showed that a chromosome 6 locus, IgK-Ef2, controls a pair of prominent bands in normal mouse light-chain isoelectric focusing profiles. Screening of myeloma light chains derived from BALB/c mice (an IgK-EF2 alpha strain) led to the identification of seven light chains cofocusing with the polymorphic bands controlled by IgK-Ef2.
C, Lazure, W T, Hum, D M, Gibson
openaire   +2 more sources

A Scalable Framework for Comprehensive Typing of Polymorphic Immune Genes from Long‐Read Data

Advanced Science, EarlyView.
SpecImmune introduces a unified computational framework optimized for long‐read sequencing to resolve over 400 highly polymorphic immune genes. This scalable approach achieves high‐resolution typing, enabling the discovery of cross‐family co‐evolutionary networks and population‐specific diversity.
Shuai Wang, Xuedong Wang, Mengyao Wang, Qian Zhou, Lusheng Wang, Shuai Cheng Li   +5 more
wiley   +1 more source

The Influence of Renal Function Impairment on Kappa Free Light Chains in Cerebrospinal Fluid

Journal of Central Nervous System Disease, 2021
Background The determination of kappa free light chains (KFLC) in cerebrospinal fluid (CSF) is an upcoming biomarker for the detection of an intrathecal immunoglobulin synthesis.
Franz F Konen, Philipp Schwenkenbecher, Ulrich Wurster, Konstantin F Jendretzky, Nora Möhn, Stefan Gingele, Kurt-Wolfram Sühs, Malte J Hannich, Matthias Grothe, Torsten Witte, Martin Stangel, Marie Süße, Thomas Skripuletz   +12 more
doaj   +1 more source

Immunoglobulin allotypes of rabbit kappa chains: polymorphism of a control mechanism regulating closely linked duplicated genes? [PDF]

Proceedings of the National Academy of Sciences, 1976
The amino acid sequence of the constant (CK) region from the kappa immunoglobulin chains of a b9 rabbit is compared with the CK sequences, taken from the literature, of a b4 rabbit. These CK regions differ by 33% of their amino acid sequences and by three sequence insertions or deletions (sequence gaps).
V, Farnsworth, R, Goodfliesh, S, Rodkey, L, Hood   +3 more
openaire   +2 more sources

Peptide‐Incorporated Biomaterials Promote Regeneration of Peripheral Nerve Injuries

Advanced Science, EarlyView.
Peptide‐incorporated biomaterials provide precise, tunable biological cues that mimic functional protein domains to regulate behaviors of neurons, Schwann cells, immune cells, and endothelial cells, thereby enhancing axon elongation, Schwann cell support, inflammatory microenvironment modulation, and vascularization, offering a promising alternative to
Zhiwei Zhao, Jianfeng Liu, Jincheng Li, Di Li, Jianxun Ding, Bin Liu   +5 more
wiley   +1 more source

Lambda light chain-induced monoclonal gammopathy of renal significance, manifesting with Fanconi Syndrome and osteomalacia

BMC Nephrology, 2022
Background Monoclonal gammopathy of renal significance (MGRS) encompasses a heterogeneous group of kidney diseases in which a monoclonal immunoglobulin secreted by a clone of B cells or plasma cells causes kidney damage without meeting the hematological ...
Gabriel Brayan Gutiérrez-Peredo, José César Batista Oliveira Filho, Iris Montaño-Castellón, Andrea Jimena Gutiérrez-Peredo, Edvan de Queiroz Crusoé, Dimitri Gusmao-Flores   +5 more
doaj   +1 more source

The kappa/lambda ratio of surface immunoglobulin light chain as a valuable parameter for MRD assessment in CLL with atypical immunophenotype

Scientific Reports
In recent years, the significance of detecting minimal/measurable residual disease (MRD) in chronic lymphocytic leukemia (CLL) has increased due to the availability of highly effective therapeutic agents.
Yu Aruga, Chiaki Ikeda, Hiromichi Matsushita, Shinichi Makita, Suguru Fukuhara, Wataru Munakata, Koji Izutsu, Hirotaka Matsui   +7 more
doaj   +1 more source

Physiological level production of antigen-specific human immunoglobulin in cloned transchromosomic cattle. [PDF]

PLoS ONE, 2013
Therapeutic human polyclonal antibodies (hpAbs) derived from pooled plasma from human donors are Food and Drug Administration approved biologics used in the treatment of a variety of human diseases.
Akiko Sano, Hiroaki Matsushita, Hua Wu, Jin-An Jiao, Poothappillai Kasinathan, Eddie J Sullivan, Zhongde Wang, Yoshimi Kuroiwa   +7 more
doaj   +1 more source

Related Article from For Breast Cancer Prognosis, Immunoglobulin Kappa Chain Surfaces to the Top

, 2023
Related Article from For Breast Cancer Prognosis, Immunoglobulin Kappa Chain Surfaces to the ...
Soldano Ferrone, Theresa L. Whiteside
openaire   +1 more source