Results 11 to 20 of about 326,951 (318)

Variable Region Identical Immunoglobulins Differing in Isotype Express Different Paratopes [PDF]

Journal of Biological Chemistry, 2012
The finding that the antibody (Ab) constant (C) region can influence fine specificity suggests that isotype switching contributes to the generation of Ab diversity and idiotype restriction. Despite the centrality of this observation for diverse immunological effects such as vaccine responses, isotype-restricted antibody responses, and the origin of ...
Alena, Janda, Ertan, Eryilmaz, Antonio, Nakouzi, David, Cowburn, Arturo, Casadevall   +4 more
openaire   +4 more sources

GANP-mediated Recruitment of Activation-induced Cytidine Deaminase to Cell Nuclei and to Immunoglobulin Variable Region DNA* [PDF]

Journal of Biological Chemistry, 2010
AID (activation-induced cytidine deaminase) catalyzes transcription-dependent deamination of C → U in immunoglobulin variable (IgV) regions to initiate somatic hypermutation (SHM) in germinal center B-cells.
K. Maeda, Shailendra Kumar Singh, Kazufumi Eda, M. Kitabatake, P. Pham, M. Goodman, N. Sakaguchi   +6 more
semanticscholar   +2 more sources

Somatic Mutation in Immunoglobulin Gene Variable Region in Patients with Chronic Lymphocytic Leukemia and Prognostic Impact

Basic & Clinical Cancer Research, 2017
Chronic lymphocyte leukemia (CLL) is the most common leukemia in elderly individuals that is accompanied by the presence of CD5/CD19/CD20/CD23 positive, FMC7 negative and reduced levels of surface membrane Immunoglobuline (IgM & IgD), CD79b on B ...
Mehrnoosh Pashaei, Mahdieh Shokrollahi, Parviz Kokhaei   +2 more
doaj   +1 more source

Determination of variable region sequences from hybridoma immunoglobulins that target Mycobacterium tuberculosis virulence factors.

PLoS ONE, 2021
Mycobacterium tuberculosis (Mtb) infects one-quarter of the world's population. Mtb and HIV coinfections enhance the comorbidity of tuberculosis (TB) and AIDS, accounting for one-third of all AIDS-associated mortalities.
Hui-Chen Chang Foreman, Andrew Frank, Timothy T Stedman   +2 more
doaj   +2 more sources

TET3 dioxygenase modulates gene conversion at the avian immunoglobulin variable region via demethylation of non-CpG sites in pseudogene templates. [PDF]

Genes Cells, 2021
Takamura N, Seo H, Ohta K.
europepmc   +3 more sources

Immunoglobulin Heavy Chain Locus Variable Region Mutation [PDF]

, 2020
National Cancer Institute
openaire   +2 more sources

Segmental duplication as one of the driving forces underlying the diversity of the human immunoglobulin heavy chain variable gene region [PDF]

BMC Genomics, 2011
Background Segmental duplication and deletion were implicated for a region containing the human immunoglobulin heavy chain variable (IGHV) gene segments, 1.9III/hv3005 (possible allelic variants of IGHV3-30) and hv3019b9 (a possible allelic variant of ...
Gao Richeng, Shen Li, Hu Guohong, Chimge Nyam-Osor, Wang Hui-Yun, Cui Xiangfeng, Pramanik Sreemanta, Li Honghua   +7 more
doaj   +2 more sources

Molecular Single-Cell Analysis of Hodgkin- and Reed-Sternberg Cells Harboring Unmutated Immunoglobulin Variable Region Genes [PDF]

Laboratory Investigation, 2001
M. Müschen, R. Küppers, Tilmann Spieker, A. Bräuninger, K. Rajewsky, M. Hansmann   +5 more
semanticscholar   +2 more sources

[Application of next-generation sequencing technology for the investigation of immunoglobulin variable region characteristics and their prognostic significance in patients with chronic lymphocytic leukemia]. [PDF]

Zhonghua Xue Ye Xue Za Zhi
Guo Z, Jin HM, Qiu TL, Zhu LY, Wu YJ, Qiu HR, Wang Y, Miao Y, Jin H, Fan L, Li JY, Xia Y, Qiao C.   +12 more
europepmc   +3 more sources

Human-likeness of antibody biologics determined by back-translation and comparison with large antibody variable gene repertoires

mAbs, 2020
The antibody (Ab) germline gene rearrangement of variable (V), diversity (D), and joining (J) gene segments, as well as somatic hypermutation, give rise to the human Ab variable gene sequence repertoire.
Samuel Schmitz, Cinque Soto, James E. Crowe, Jens Meiler   +3 more
doaj   +1 more source