Results 21 to 30 of about 326,951 (318)

Identification of the 48-base-long primordial building block sequence of mouse immunoglobulin variable region genes. [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 1982
S. Ohno, T. Matsunaga, R. Wallace
semanticscholar   +2 more sources

Immunoglobulin variable-region-like domains of diverse sequence within the major histocompatibility complex of the chicken.

Proceedings of the National Academy of Sciences of the United States of America, 1991
Marcia M. Miller, R. Goto, Sharon Young, Jose Chirivella, David HAWKEt, C. G. Miyada   +5 more
semanticscholar   +3 more sources

Common light chain chickens produce human antibodies of high affinity and broad epitope coverage for the engineering of bispecifics

mAbs, 2021
Bispecific antibodies are an important and growing segment in antibody therapeutics, particularly in the immuno-oncology space. Manufacturing of a bispecific antibody with two different heavy chains is greatly simplified if the light chains can be the ...
Kathryn H. Ching, Kimberley Berg, Kevin Reynolds, Darlene Pedersen, Alba Macias, Yasmina N. Abdiche, William D. Harriman, Philip A. Leighton   +7 more
doaj   +1 more source

Ig constant region effects on variable region structure and function

Frontiers in Microbiology, 2016
The adaptive humoral immune response is responsible for the generation of antimicrobial proteins known as immunoglobulin molecules or antibodies. Immunoglobulins provide a defense system against pathogenic microbes and toxins by targeting them for ...
Alena eJanda, Anthony eBowen, Neil S Greenspan, Arturo eCasadevall   +3 more
doaj   +1 more source

Interaction of clinical-stage antibodies with heme predicts their physiochemical and binding qualities

Communications Biology, 2021
Lecerf et al. examine over 100 samples with variable region sequences matching clinical-stage immunoglobulin antibodies, to demonstrate that many interact with heme.
Maxime Lecerf, Alexia Kanyavuz, Sofia Rossini, Jordan D. Dimitrov   +3 more
doaj   +1 more source

Igh Locus Polymorphism May Dictate Topological Chromatin Conformation and V Gene Usage in the Ig Repertoire

Frontiers in Immunology, 2021
Vast repertoires of unique antigen receptors are created in developing B and T lymphocytes. The antigen receptor loci contain many variable (V), diversity (D) and joining (J) gene segments that are arrayed across very large genomic expanses and are ...
Amy L. Kenter, Corey T. Watson, Jan-Hendrik Spille   +2 more
doaj   +1 more source

Development of the expressed immunoglobulin μ chain repertoire during maturation of mice B cells [PDF]

Frontiers of Agricultural Science and Engineering, 2014
In the bone marrow and spleen, the developing B cell populations undergo both negative and positive selections to shape their B cell receptor repertoire.
Jingwen LIANG,Yingfeng LUO,Yi SUN,Meng LEI,Bing ZHANG,Songnian HU,Yaofeng ZHAO
doaj   +1 more source

Plasma proteomic profiling suggests an association between antigen driven clonal B cell expansion and ME/CFS.

PLoS ONE, 2020
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is an unexplained chronic, debilitating illness characterized by fatigue, sleep disturbances, cognitive dysfunction, orthostatic intolerance and gastrointestinal problems.
Milica Milivojevic, Xiaoyu Che, Lucinda Bateman, Aaron Cheng, Benjamin A Garcia, Mady Hornig, Manuel Huber, Nancy G Klimas, Bohyun Lee, Hyoungjoo Lee, Susan Levine, Jose G Montoya, Daniel L Peterson, Anthony L Komaroff, W Ian Lipkin   +14 more
doaj   +1 more source

Computational Inference, Validation, and Analysis of 5’UTR-Leader Sequences of Alleles of Immunoglobulin Heavy Chain Variable Genes

Frontiers in Immunology, 2021
Upstream and downstream sequences of immunoglobulin genes may affect the expression of such genes. However, these sequences are rarely studied or characterized in most studies of immunoglobulin repertoires. Inference from large, rearranged immunoglobulin
Yixun Huang, Linnea Thörnqvist, Mats Ohlin   +2 more
doaj   +1 more source

Controlling somatic hypermutation in immunoglobulin variable and switch regions [PDF]

Immunologic Research, 2010
Activation-induced deaminase (AID) is a B-cell-specific enzyme required for initiating the mechanisms of affinity maturation and isotype switching of antibodies. AID functions by deaminating cytosine to uracil in DNA, which initiates a cascade of events resulting in mutations and strand breaks in the immunoglobulin loci. There is an intricate interplay
Robert W, Maul, Patricia J, Gearhart
openaire   +2 more sources