Results 31 to 40 of about 321,783 (122)

MDM2 promotor polymorphism and disease characteristics in chronic lymphocytic leukemia: results of an individual patient data-based meta-analysis

Haematologica, 2014
A number of single nucleotide polymorphisms have been associated with disease predisposition in chronic lymphocytic leukemia. A single nucleotide polymorphism in the MDM2 promotor region, MDM2SNP309, was shown to soothe the p53 pathway.
Axel Benner, Larry Mansouri, Davide Rossi, Aneela Majid, Kerstin Willander, Anton Parker, Gareth Bond, Sarka Pavlova, Holger Nückel, Olaf Merkel, Paolo Ghia, Emili Montserrat, Mohd Arifin Kaderi, Richard Rosenquist, Gianluca Gaidano, Martin J.S. Dyer, Peter Söderkvist, Mats Linderholm, David Oscier, Zuzana Tvaruzkova, Sarka Pospisilova, Ulrich Dührsen, Richard Greil, Hartmut Döhner, Stephan Stilgenbauer, Thorsten Zenz   +25 more
doaj   +1 more source

Reprogramming the Constant Region of Immunoglobulin G Subclasses for Enhanced Therapeutic Potency against Cancer

Biomolecules, 2020
The constant region of immunoglobulin (Ig) G antibodies is responsible for their effector immune mechanism and prolongs serum half-life, while the fragment variable (Fv) region is responsible for cellular or tissue targeting.
Tae Hyun Kang, Sang Taek Jung
doaj   +1 more source

IgTreeZ, A Toolkit for Immunoglobulin Gene Lineage Tree-Based Analysis, Reveals CDR3s Are Crucial for Selection Analysis

Frontiers in Immunology, 2022
Somatic hypermutation (SHM) is an important diversification mechanism that plays a part in the creation of immune memory. Immunoglobulin (Ig) variable region gene lineage trees were used over the last four decades to model SHM and the selection ...
Hadas Neuman, Jessica Arrouasse, Meirav Kedmi, Meirav Kedmi, Meirav Kedmi, Andrea Cerutti, Andrea Cerutti, Giuliana Magri, Ramit Mehr   +8 more
doaj   +1 more source

Construction and characterization of single-chain variable fragment antibody library derived from germline rearranged immunoglobulin variable genes. [PDF]

PLoS ONE, 2011
Antibody repertoires for library construction are conventionally harvested from mRNAs of immune cells. To examine whether germline rearranged immunoglobulin (Ig) variable region genes could be used as source of antibody repertoire, an immunized phage ...
Man Cheng, Shirley Y W Chan, Qi Zhao, Elaine Y M Chan, Shannon W N Au, Susanna S T Lee, Wing-Tai Cheung   +6 more
doaj   +1 more source

Per-sample immunoglobulin germline inference from B cell receptor deep sequencing data [PDF]

PLoS Comput Biol 15(7): e1007133 (2019), 2017
The collection of immunoglobulin genes in an individual's germline, which gives rise to B cell receptors via recombination, is known to vary significantly across individuals. In humans, for example, each individual has only a fraction of the several hundred known V alleles.
arxiv   +1 more source

A comprehensive analysis of immunoglobulin heavy chain genes in the Bactrian camel (Camelus bactrianus) [PDF]

Frontiers of Agricultural Science and Engineering, 2015
Heavy chain only antibodies (HCAbs) represent a rare type of antibody that is devoid of light chains and the CH1 domain that have been reported in cartilaginous fish and camelids.
Zuoxiang LIANG,Tao WANG,Yi SUN,Wenlong YANG,Zhihong LIU,Jing FEI,Ying GUO,Qingwei MA,Qingjie PAN,Liming REN
doaj   +1 more source

Amplification and analysis of cDNA generated from a single cell by 5′-RACE: application to isolation of antibody heavy and light chain variable gene sequences from single B cells

BioTechniques, 2006
The technique of 5′-rapid amplification of cDNA ends (5′-RACE) is widely used to amplify unknown sequences at the 5′ end of a messenger RNA (mRNA). However, conventional 5′-RACE is inappropriate for producing cDNAs from a single cell due to the small ...
Tatsuhiko Ozawa, Hiroyuki Kishi, Atsushi Muraguchi   +2 more
doaj   +1 more source

BIMCV COVID-19+: a large annotated dataset of RX and CT images from COVID-19 patients [PDF]

arXiv, 2020
This paper describes BIMCV COVID-19+, a large dataset from the Valencian Region Medical ImageBank (BIMCV) containing chest X-ray images CXR (CR, DX) and computed tomography (CT) imaging of COVID-19+ patients along with their radiological findings and locations, pathologies, radiological reports (in Spanish), DICOM metadata, Polymerase chain reaction ...
arxiv  

Immunoglobulin secretion influences the composition of chicken caecal microbiota

Scientific Reports
The chicken caecum is colonised by hundreds of different bacterial species. Which of these are targeted by immunoglobulins and how immunoglobulin expression shapes chicken caecal microbiota has been addressed in this study. Using cell sorting followed by
Jiri Volf, Bernd Kaspers, Benjamin Schusser, Magdalena Crhanova, Daniela Karasova, Hana Stepanova, Vladimir Babak, Ivan Rychlik   +7 more
doaj   +1 more source

Comparative genomic analysis and evolution of the T cell receptor loci in the opossum Monodelphis domestica

BMC Genomics, 2008
Background All jawed-vertebrates have four T cell receptor (TCR) chains: alpha (TRA), beta (TRB), gamma (TRG) and delta (TRD). Marsupials appear unique by having an additional TCR: mu (TRM).
Sharp Alana, Trujillo Jonathan, Lopez April M, Hathaway Jennifer, Baker Michelle L, Parra Zuly E, Miller Robert D   +6 more
doaj   +1 more source