Results 41 to 50 of about 326,951 (318)

Multiple productive immunoglobulin heavy chain gene rearrangements in chronic lymphocytic leukemia are mostly derived from independent clones

Haematologica, 2014
In chronic lymphocytic leukemia, usually a monoclonal disease, multiple productive immunoglobulin heavy chain gene rearrangements are identified sporadically. Prognostication of such cases based on immunoglobulin heavy variable gene mutational status can
Karla Plevova, Hana Skuhrova Francova, Katerina Burckova, Yvona Brychtova, Michael Doubek, Sarka Pavlova, Jitka Malcikova, Jiri Mayer, Boris Tichy, Sarka Pospisilova   +9 more
doaj   +1 more source

98% IGHV gene identity is the optimal cutoff to dichotomize the prognosis of Chinese patients with chronic lymphocytic leukemia

Cancer Medicine, 2020
Immunoglobulin heavy chain variable region (IGHV) mutational status has been an important prognostic factor for chronic lymphocytic leukemia (CLL) for decades.
Ke Shi, Qian Sun, Chun Qiao, Huayuan Zhu, Li Wang, Jiazhu Wu, Lili Wang, Jianxin Fu, Ken H. Young, Lei Fan, Yi Xia, Wei Xu, Jianyong Li   +12 more
doaj   +1 more source

HIV gp120 Induces the Release of Proinflammatory, Angiogenic, and Lymphangiogenic Factors from Human Lung Mast Cells

Vaccines, 2020
Human lung mast cells (HLMCs) express the high-affinity receptor FcεRI for IgE and are involved in chronic pulmonary diseases occurring at high frequency among HIV-infected individuals.
Giancarlo Marone, Francesca Wanda Rossi, Antonio Pecoraro, Valentina Pucino, Gjada Criscuolo, Amato de Paulis, Giuseppe Spadaro, Gianni Marone, Gilda Varricchi   +8 more
doaj   +1 more source

Differences in human IgG1 and IgG4 S228P monoclonal antibodies viscosity and self-interactions: Experimental assessment and computational predictions of domain interactions

mAbs, 2021
Human/humanized IgG4 antibodies have reduced effector function relative to IgG1 antibodies, which is desirable for certain therapeutic purposes. However, the developability and biophysical properties for IgG4 antibodies are not well understood. This work
Pin-Kuang Lai, Gaurav Ghag, Yao Yu, Veronica Juan, Laurence Fayadat-Dilman, Bernhardt L. Trout   +5 more
doaj   +1 more source

Preferential use of unmutated immunoglobulin heavy variable region genes in Boxer dogs with chronic lymphocytic leukemia.

PLoS ONE, 2018
Human chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease, and immunoglobulin heavy variable region (IGHV) gene mutational status is an important prognostic marker.
Emily D Rout, Robert C Burnett, Julia D Labadie, Janna A Yoshimoto, Anne C Avery   +4 more
doaj   +1 more source

Developmental progression of equine immunoglobulin heavy chain variable region diversity [PDF]

Developmental & Comparative Immunology, 2013
Humoral immunity is a critical component of the immune system that is established during fetal life and expands upon exposure to pathogens. The extensive humoral immune response repertoire is generated in large part via immunoglobulin (Ig) heavy chain variable region diversity.
Rebecca L, Tallmadge, Chia T, Tseng, Rebecca A, King, M Julia B, Felippe   +3 more
openaire   +2 more sources

Sequence analysis of variable regions of human monoclonal anti-P immunoglobulin

Zhongguo shuxue zazhi
[Objective] To identify the structure of the complementarity determining region (CDRs), the V(D)J rearrangement and somatic hypermutational characteristics of the heavy and light chains of a red blood cell blood group-specific monoclonal antibody ...
GUO Zhonghui, XIANG Dong, LI Qin, ZHU Ziyan   +3 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Comprehensive analysis of immunoglobulin expression in the mouse brain from embryonic to adult stages

Journal of Neuroinflammation
Immunoglobulin (Ig) is a critical molecule in the body’s defense against foreign substances such as bacteria and viruses. While traditionally considered B cell specific, studies have reported that Ig is also expressed by non-B cells.
Keiko Morimoto, Hitomi Sano, Michiko Takahashi, Rikuo Takahashi, Kazunori Nakajima   +4 more
doaj   +1 more source

IgTreeZ, A Toolkit for Immunoglobulin Gene Lineage Tree-Based Analysis, Reveals CDR3s Are Crucial for Selection Analysis

Frontiers in Immunology, 2022
Somatic hypermutation (SHM) is an important diversification mechanism that plays a part in the creation of immune memory. Immunoglobulin (Ig) variable region gene lineage trees were used over the last four decades to model SHM and the selection ...
Hadas Neuman, Jessica Arrouasse, Meirav Kedmi, Meirav Kedmi, Meirav Kedmi, Andrea Cerutti, Andrea Cerutti, Giuliana Magri, Ramit Mehr   +8 more
doaj   +1 more source