Results 41 to 50 of about 321,783 (122)
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023 Background Finding effective and safe therapeutic drugs for atrial fibrillation (AF) is an important concern for clinicians. Proteome‐wide Mendelian randomization analysis provides new ideas for finding potential drug targets. Methods and Results Using a
Xinpei Wang, Tao Huang, Jinzhu Jia
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Frontiers in Immunology, 2022 In response to T-cell-dependent antigens, mature B cells in the secondary lymphoid organs are stimulated to form germinal centers (GCs), which are histological structures deputed to antibody affinity maturation, a process associated with immunoglobulin ...
Clarissa Corinaldesi +13 more
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SAIVGeM: spreadsheet analysis of immunoglobulin VH gene mutations
BioTechniques, 2005 The analysis of mutations in immunoglobulin heavy chain variable (IGHV) region genes is a tedious process when performed by hand on multiple sequences. This report describes a set of linked Microsoft® Excel® files that perform several common analyses on ...
Bradley T. Messmer
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Lack of evidence for a substantial rate of templated mutagenesis in B cell diversification [PDF]
arXiv, 2020 B cell receptor sequences diversify through mutations introduced by purpose-built cellular machinery. A recent paper has concluded that a "templated mutagenesis" process is a major contributor to somatic hypermutation, and therefore immunoglobulin diversification, in mice and humans.
arxiv
Combined force-torque spectroscopy of proteins by means of multiscale molecular simulation [PDF]
, 2019 Assessing the structural properties of large proteins is important to gain an understanding of their function in, e.g., biological systems or biomedical applications. We propose a method to examine the mechanical properties of proteins subject to applied forces by means of multiscale simulation.
arxiv +1 more source
De novo inference of diversity genes and analysis of non-canonical V(DD)J recombination in immunoglobulins [PDF]
arXiv, 2019 The V(D)J recombination forms the immunoglobulin genes by joining the variable (V), diversity (D), and joining (J) germline genes. Since variations in germline genes have been linked to various diseases, personalized immunogenomics aims at finding alleles of germline genes across various patients.
arxiv
In Silico Prediction Analysis of Idiotope-Driven T–B Cell Collaboration in Multiple Sclerosis
Frontiers in Immunology, 2017 Memory B cells acting as antigen-presenting cells are believed to be important in multiple sclerosis (MS), but the antigen they present remains unknown.
Rune A. Høglund +14 more
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Diversity against adversity: How adaptive immunity evolves potent antibodies [PDF]
arXiv, 2008 How does immune system evolve functional proteins - potent antibodies - in such a short time? We address this question using a microscopic, protein-level, sequence-based model of humoral immune response with explicitly defined interactions between Immunoglobulins, host and pathogen proteins.
arxiv
Evolution and Mutations of Beta 2 Microglobulin [PDF]
arXiv, 2022 Here we examine the evolution of beta-2 microglobulin in terms of its hydropathic shapes, a theoretical construct that has revealed important trends. The dynamics of many proteins are largely driven by interactions between the protein itself and the thin water film that covers it.
arxiv
A novel liver-specific immunoglobulin heavy chain-like gene in a cartilaginous fish
Fish and Shellfish Immunology Reports, 2023 We identified a novel immunoglobulin (Ig) heavy chain-like gene (tsIgH) expressed in the liver of the banded houndshark Triakis scyllium by preliminary transcriptomic analysis.
Hidehiro Kondo +7 more
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