Results 51 to 60 of about 326,951 (318)

Immunoglobulin heavy chain variable region analysis in dairy goats

Immunobiology, 2018
Based on the goat genome database, we have annotated the genomic organization of the goat immunoglobulin heavy chain variable region. The goat IgH locus is present on seven genome scaffolds, and contains ten VH, three DH and six JH segments. After the exclusion of three shorter segments, the VH genes were divided into two gene families based on ...
Lijuan Du, Shuhui Wang, Yanjiao Zhu, Haidong Zhao, Abdul Basit, Xiaohui Yu, Qingwang Li, Xiuzhu Sun   +7 more
openaire   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

MDM2 promotor polymorphism and disease characteristics in chronic lymphocytic leukemia: results of an individual patient data-based meta-analysis

Haematologica, 2014
A number of single nucleotide polymorphisms have been associated with disease predisposition in chronic lymphocytic leukemia. A single nucleotide polymorphism in the MDM2 promotor region, MDM2SNP309, was shown to soothe the p53 pathway.
Axel Benner, Larry Mansouri, Davide Rossi, Aneela Majid, Kerstin Willander, Anton Parker, Gareth Bond, Sarka Pavlova, Holger Nückel, Olaf Merkel, Paolo Ghia, Emili Montserrat, Mohd Arifin Kaderi, Richard Rosenquist, Gianluca Gaidano, Martin J.S. Dyer, Peter Söderkvist, Mats Linderholm, David Oscier, Zuzana Tvaruzkova, Sarka Pospisilova, Ulrich Dührsen, Richard Greil, Hartmut Döhner, Stephan Stilgenbauer, Thorsten Zenz   +25 more
doaj   +1 more source

Reprogramming the Constant Region of Immunoglobulin G Subclasses for Enhanced Therapeutic Potency against Cancer

Biomolecules, 2020
The constant region of immunoglobulin (Ig) G antibodies is responsible for their effector immune mechanism and prolongs serum half-life, while the fragment variable (Fv) region is responsible for cellular or tissue targeting.
Tae Hyun Kang, Sang Taek Jung
doaj   +1 more source

Construction and characterization of single-chain variable fragment antibody library derived from germline rearranged immunoglobulin variable genes. [PDF]

PLoS ONE, 2011
Antibody repertoires for library construction are conventionally harvested from mRNAs of immune cells. To examine whether germline rearranged immunoglobulin (Ig) variable region genes could be used as source of antibody repertoire, an immunized phage ...
Man Cheng, Shirley Y W Chan, Qi Zhao, Elaine Y M Chan, Shannon W N Au, Susanna S T Lee, Wing-Tai Cheung   +6 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Immunoglobulin heavy chain variable region polymorphisms and multiple sclerosis susceptibility

Journal of Neuroimmunology, 1993
In addition to the major histocompatibility complex (MHC), genetic susceptibility in multiple sclerosis (MS) appears to be influenced by other loci. A recent study has identified a population association with an immunoglobulin heavy chain variable region polymorphism in the VH2-B5 family, with both familial and sporadic MS patients.
Hashimoto, L, Walter, M, Cox, D, Ebers, G   +3 more
openaire   +2 more sources

DNA polymerase ζ generates tandem mutations in immunoglobulin variable regions [PDF]

Journal of Experimental Medicine, 2012
Low-fidelity DNA polymerases introduce nucleotide substitutions in immunoglobulin variable regions during somatic hypermutation. Although DNA polymerase (pol) η is the major low-fidelity polymerase, other DNA polymerases may also contribute. Existing data are contradictory as to whether pol ζ is involved. We reasoned that the presence of pol η may mask
Saribasak, Huseyin, Maul, Robert W., Cao, Zheng, Yang, William W., Schenten, Dominik, Kracker, Sven, Gearhart, Patricia J.   +6 more
openaire   +2 more sources

Resting small B cells present endogenous immunoglobulin variable‐region determinants to idiotope‐specific CD4+ T cells in vivo [PDF]

European Journal of Immunology, 1999
L. Munthe, J. Kyte, B. Bogen
semanticscholar   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source