Results 151 to 160 of about 491,747 (317)

ICAM-1 enhances MHC-peptide activation of CD8+ T cells without an organized immunological synapse [PDF]

, 2000
Julia Goldstein, Trina Chen, Elena Gubina, Richard W. Pastor, Steven Kozlowski   +4 more
openalex   +1 more source

The myth of the metabolic baseline: sleep–wake cycles undermine a foundational assumption in organismal biology

Biological Reviews, EarlyView.
ABSTRACT Basal and standard metabolic rate (BMR and SMR) are cornerstones of physiological ecology and are assumed to be relatively fixed intrinsic properties of organisms that represent the minimum energy required to sustain life. However, this assumption is conceptually flawed. Many core maintenance processes underlying SMR are temporally partitioned
Helena Norman, Daphne Cortese, Amelia Munson, Jan Lindström, Shaun S. Killen   +4 more
wiley   +1 more source

Nested Selves: Self‐Organization and Shared Markov Blankets in Prenatal Development in Humans

Topics in Cognitive Science, EarlyView., 2023
Abstract The immune system is a central component of organismic function in humans. This paper addresses self‐organization of biological systems in relation to—and nested within—other biological systems in pregnancy. Pregnancy constitutes a fundamental state for human embodiment and a key step in the evolution and conservation of our species. While not
Anna Ciaunica, Michael Levin, Fernando E. Rosas, Karl Friston   +3 more
wiley   +1 more source

Methods of Machine Learning-Based Chimeric Antigen Receptor Immunological Synapse Quality Quantification. [PDF]

Methods Mol Biol, 2023
Gan J, Cho JH, Lee R, Naghizadeh A, Poon LY, Wang E, Hui Z, Liu D.   +7 more
europepmc   +1 more source

The Stimulatory Potency of T Cell Antigens Is Influenced by the Formation of the Immunological Synapse [PDF]

, 2007
Sašo Čemerski, Jayajit Das, Jason W. Locasale, P.L. Arnold, Emanuele Giurisato, Mary A. Markiewicz, Daved H. Fremont, Paul M. Allen, Arup K. Chakraborty, Andréy S. Shaw   +9 more
openalex   +1 more source

Straight to Phase III: Model‐Informed Approach Speeds Depemokimab Clinical Development in Interleukin‐5‐Driven Diseases

Clinical Pharmacology &Therapeutics, EarlyView.
Straight to Phase III: Model‐informed approach speeds depemokimab clinical development in interleukin‐5‐driven diseases. IL‐5, a key mediator of type 2 inflammation, underlies various diseases, including severe asthma, CRSwNP, EGPA, and HES. Reduction in blood eosinophil count (BEC), a biomarker of IL‐5 activity, is commonly used to evaluate the ...
Chiara Zecchin, Stein Schalkwijk, Isabelle J. Pouliquen, Alienor Berges, Nicholas Bird, Richard Follows, Daren Austin   +6 more
wiley   +1 more source

Assessment of membrane lipid state at the natural killer cell immunological synapse. [PDF]

Methods Cell Biol, 2023
Li Y, Orange JS.
europepmc   +1 more source

Murine Tim-1 is excluded from the immunological synapse

, 2012
Jean Lin, Leo Chen, Larry Kane
openalex   +1 more source

WAVE2 Regulates High-Affinity Integrin Binding by Recruiting Vinculin and Talin to the Immunological Synapse [PDF]

, 2007
Jeffrey C. Nolz, Ricardo B. Medeiros, Jason S. Mitchell, Peimin Zhu, Bruce D. Freedman, Yoji Shimizu, Daniel D. Billadeau   +6 more
openalex   +1 more source

Population dynamics of immunological synapse formation induced by bispecific T cell engagers predict clinical pharmacodynamics and treatment resistance. [PDF]

Elife, 2023
Liu C, Zhou J, Kudlacek S, Qi T, Dunlap T, Cao Y.   +5 more
europepmc   +1 more source