Results 71 to 80 of about 491,747 (317)

Immunological Synapse

, 2015
Immunological synapses are dynamically organised cell–cell interfaces formed between cells of the immune system. Different types of immunological synapses lead to distinct functional outcomes. Thus, T and B lymphocytes form immunological synapses with each other and with dendritic cells or macrophages, conveying mutual activation cues.
Agüera-Gonzalez, Sonia, Bouchet, Jérôme, Alcover, Andrés   +2 more
openaire   +2 more sources

Immunological Synapse in the Biology of Chronic Lymphocytic Leukemia

Клиническая онкогематология, 2018
Chronic lymphocytic leukemia (CLL) is a lymphoproliferative disease manifested by accumulation of tumor B-cells with characteristic immunophenotype (CD19+CD5+CD23+) in bone marrow, peripheral blood and secondary lymphoid organs.
Darima Semunkoevna Badmazhapova, I. V. Gal’tseva, E. E. Zvonkov   +2 more
doaj   +1 more source

Cholesterol‐DNA Origami Nanostructures for Synthetic Lipid Rafts Induce Early T Cell Activation Signals

Advanced Materials Interfaces, EarlyView.
Here, we present a nanotechnology approach to construct synthetic lipid rafts on the live T cell membrane, leveraging a versatile DNA origami‐enabled platform named as the “cholesterol nano‐patch” (CNP). Our investigation highlights the effectiveness of DNA nanotechnology in exploring the impact of nanoscale arrangement of cholesterols on the ...
Yunmin Jung, Young‐Joo Kim, Kunwoo Noh, Sunmi Lee, Minsuk Kwak   +4 more
wiley   +1 more source

T-cell trans-synaptic vesicles are distinct and carry greater effector content than constitutive extracellular vesicles

Nature Communications, 2022
T cells communicate with antigen-presenting cells (APC) via the signaling crosstalk at the immunological synapse (IS). Here the authors use bead-supported lipid bilayers as synthetic APCs to find that trans-synaptic vesicles produced by T cells in the IS
Pablo F. Céspedes, Ashwin Jainarayanan, Lola Fernández-Messina, Salvatore Valvo, David G. Saliba, Elke Kurz, Audun Kvalvaag, Lina Chen, Charity Ganskow, Huw Colin-York, Marco Fritzsche, Yanchun Peng, Tao Dong, Errin Johnson, Jesús A. Siller-Farfán, Omer Dushek, Erdinc Sezgin, Ben Peacock, Alice Law, Dimitri Aubert, Simon Engledow, Moustafa Attar, Svenja Hester, Roman Fischer, Francisco Sánchez-Madrid, Michael L. Dustin   +25 more
doaj   +1 more source

Neural Circuits between Nodose Ganglion and Pulmonary Neuroendocrine Cells Regulate Lung Inflammatory Responses

Advanced Science, EarlyView.
TRPA1+αCGRP+ sensory neurons in the nodose ganglion detect external insults such as lipopolysaccharide (LPS) and interact directly with pulmonary neuroendocrine cells (PNECs), promoting their activation and proliferation. This neural‐epithelial interaction amplifies lung inflammation.
Jie Chen, Shitao Xie, Zhekai Lin, Caiqi Zhao, Rujia Tao, Yingying Ma, Xiaoyan Chen, Renlan Wu, Qingjian Han, Pengfei Sui, Sheng Wang, Hongbin Ji, Hai Song, Xiaoming Zhang, Yangang Sun, Yuanlin Song, Xiao Su   +16 more
wiley   +1 more source

A role for TASK2 channels in the human immunological synapse

European Journal of Immunology, 2020
The immunological synapse is a transient junction that occurs when the plasma membrane of a T cell comes in close contact with an APC after recognizing a peptide from the antigen‐MHC.
J. Fernández-Orth, L. Rolfes, L. Gola, S. Bittner, Joseph Andronic, V. Sukhorukov, Dmitri Sisario, P. Landgraf, D. Dieterich, M. Cerina, K. Smalla, T. Kähne, T. Budde, S. Kovac, T. Ruck, M. Sauer, S. Meuth   +16 more
semanticscholar   +1 more source

Mechanical Communication at the Immunological Synapse. [PDF]

Trends in Cell Biology, 2017
T and B lymphocytes communicate by forming immunological synapses with antigen-presenting target cells. These highly dynamic contacts are characterized by continuous cytoskeletal remodeling events, which not only structure the interface but also exert a considerable amount of mechanical force.
Roshni Basu, M. Huse
semanticscholar   +3 more sources

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Advanced Science, EarlyView.
Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri   +8 more
wiley   +1 more source

A major secretory defect of tumour-infiltrating T lymphocytes due to galectin impairing LFA-1-mediated synapse completion

Nature Communications, 2016
Galectin-3 is a sugar-binding protein that can inhibit antitumour cytotoxic immunity. Here the authors show that Galectin-3 expressed by tumour cells inhibits LFA-1 on cytotoxic lymphocytes, impairing immunological synapse formation, IFNg secretion, and ...
Anne-Elisabeth Petit, Nathalie Demotte, Benoît Scheid, Claude Wildmann, René Bigirimana, Monica Gordon-Alonso, Javier Carrasco, Salvatore Valitutti, Danièle Godelaine, Pierre van der Bruggen   +9 more
doaj   +1 more source

Geometrically repatterned immunological synapses uncover formation mechanisms. [PDF]

PLoS Computational Biology, 2006
The interaction of T cells and antigen-presenting cells is central to adaptive immunity and involves the formation of immunological synapses in many cases.
Marc Thilo Figge, Michael Meyer-Hermann
doaj   +1 more source