Results 11 to 20 of about 74,853 (208)

Effect of intermittent preventive treatment for malaria with dihydroartemisinin-piperaquine on immune responses to vaccines among rural Ugandan adolescents: randomised controlled trial protocol B for the ‘POPulation differences in VACcine responses’ (POPVAC) programme

BMJ Open, 2021
Introduction Drivers of lower vaccine efficacy and impaired vaccine-specific immune responses in low-income versus high-income countries, and in rural compared with urban settings, are not fully elucidated.
, Pontiano Kaleebu, Emily Webb, Moses Muwanga, Gyaviira Nkurunungi, Ludoviko Zirimenya, Agnes Natukunda, Jacent Nassuuna, Gloria Oduru, Caroline Ninsiima, Christopher Zziwa, Florence Akello, Robert Kizindo, Mirriam Akello, Anne Wajja, Henry Luzze, Stephen Cose, Alison M Elliott, Alison Elliott, Rebecca Amongin, Beatrice Nassanga, Irene Nambuya, Prossy Kabuubi, Emmanuel Niwagaba, Grace Kabami, Helen Akurut, Alex Mutebe, Milly Namutebi, Caroline Onen, Esther Nakazibwe, Josephine Tumusiime, Susan Amongi, Moses Sewankambo, Denis Nsubuga, Samuel Kiwanuka, Fred Kiwudhu, David Abiriga, Moses Kizza, Samsi Nansukusa, Hermelijn Smits, Maria Yazdanbakhsh, Govert van Dam, Paul Corstjens, Sarah Staedke, James Kaweesa, Edridah Tukahebwa, Elly Tumushabe, Prossy N Kabuubi, Joel Serubanja, Sarah G Staedke   +49 more
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Effect of intensive treatment for schistosomiasis on immune responses to vaccines among rural Ugandan island adolescents: randomised controlled trial protocol A for the ‘POPulation differences in VACcine responses’ (POPVAC) programme

BMJ Open, 2021
Introduction Several licensed and investigational vaccines have lower efficacy, and induce impaired immune responses, in low-income versus high-income countries and in rural, versus urban, settings. Understanding these population differences is essential
, Pontiano Kaleebu, Emily Webb, Moses Muwanga, Gyaviira Nkurunungi, Ludoviko Zirimenya, Agnes Natukunda, Jacent Nassuuna, Gloria Oduru, Caroline Ninsiima, Christopher Zziwa, Florence Akello, Robert Kizindo, Mirriam Akello, Anne Wajja, Henry Luzze, Stephen Cose, Alison M Elliott, Alison Elliott, Rebecca Amongin, Beatrice Nassanga, Irene Nambuya, Prossy Kabuubi, Emmanuel Niwagaba, Grace Kabami, Helen Akurut, Alex Mutebe, Milly Namutebi, Caroline Onen, Esther Nakazibwe, Josephine Tumusiime, Susan Amongi, Moses Sewankambo, Denis Nsubuga, Samuel Kiwanuka, Fred Kiwudhu, David Abiriga, Moses Kizza, Samsi Nansukusa, Hermelijn Smits, Maria Yazdanbakhsh, Govert van Dam, Paul Corstjens, Sarah Staedke, James Kaweesa, Edridah Tukahebwa, Elly Tumushabe, Prossy N Kabuubi, Joel Serubanja   +48 more
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Population differences in vaccine responses (POPVAC): scientific rationale and cross-cutting analyses for three linked, randomised controlled trials assessing the role, reversibility and mediators of immunomodulation by chronic infections in the tropics

BMJ Open, 2021
Introduction Vaccine-specific immune responses vary between populations and are often impaired in low income, rural settings. Drivers of these differences are not fully elucidated, hampering identification of strategies for optimising vaccine ...
, Pontiano Kaleebu, Emily Webb, Moses Muwanga, Gyaviira Nkurunungi, Ludoviko Zirimenya, Agnes Natukunda, Jacent Nassuuna, Gloria Oduru, Caroline Ninsiima, Christopher Zziwa, Florence Akello, Robert Kizindo, Mirriam Akello, Anne Wajja, Henry Luzze, Stephen Cose, Alison M Elliott, Alison Elliott, Rebecca Amongin, Beatrice Nassanga, Irene Nambuya, Prossy Kabuubi, Emmanuel Niwagaba, Grace Kabami, Helen Akurut, Alex Mutebe, Milly Namutebi, Caroline Onen, Esther Nakazibwe, Josephine Tumusiime, Susan Amongi, Moses Sewankambo, Denis Nsubuga, Samuel Kiwanuka, Fred Kiwudhu, David Abiriga, Moses Kizza, Samsi Nansukusa, Hermelijn Smits, Maria Yazdanbakhsh, Govert van Dam, Paul Corstjens, Sarah Staedke, James Kaweesa, Edridah Tukahebwa, Elly Tumushabe   +46 more
doaj   +1 more source

The determinants of lipid profiles in early adolescence in a Ugandan birth cohort

Scientific Reports, 2021
Dyslipidaemia in adolescence tracks into adulthood and is an important risk factor for cardiovascular disease. Little is known about the effects of environmental exposures and early-life exposure to infectious diseases common to tropical regions on ...
Jan Pieter R. Koopman, Swaib A. Lule, Christopher Zziwa, Hellen Akurut, Lawrence Lubyayi, Margaret Nampijja, Florence Akello, Priscilla Balungi, Josephine Tumusiime, Gloria Oduru, Alison M. Elliott, Emily L. Webb, John Bradley   +12 more
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alpha2,3 sialic acid processing enzymes expression in gastric cancer tissues reveals that ST3Gal3 but not Neu3 are associated with Lauren's classification, angiolymphatic invasion and histological grade

European Journal of Histochemistry, 2022
Gastric cancer (GC) is one of the leading causes of cancer-related deaths worldwide. Despite progress in the last decades, there are still no reliable biomarkers for the diagnosis of and prognosis for GC.
Michael W.L. Quirino, Amanda P.B. Albuquerque, Maria F.D. de Souza, Antônio F. da Silva Filho, Mário R. Martins, Maira G. da Rocha Pitta, Michelly C. Pereira, Moacyr J.B. de Melo Rêgo   +7 more
doaj   +1 more source

Endothelial β-Catenin Deficiency Causes Blood-Brain Barrier Breakdown via Enhancing the Paracellular and Transcellular Permeability

Frontiers in Molecular Neuroscience, 2022
Disruption of the blood-brain barrier (BBB) causes or contributes to neuronal dysfunction and several central nervous system (CNS) disorders. Wnt/β-catenin signaling is essential for maintaining the integrity of the adult BBB in physiological and ...
Basharat Hussain, Basharat Hussain, Cheng Fang, Xiaowen Huang, Ziying Feng, Ziying Feng, Yuxuan Yao, Yu Wang, Junlei Chang   +8 more
doaj   +1 more source

RIOK2 Inhibitor NSC139021 Exerts Anti-Tumor Effects on Glioblastoma via Inducing Skp2-Mediated Cell Cycle Arrest and Apoptosis

Biomedicines, 2021
Up to now, the chemotherapy approaches for glioblastoma were limited. 1-[2-Thiazolylazo]-2-naphthol (named as NSC139021) was shown to significantly inhibit the proliferation of prostate cancer cells by targeting the atypical protein kinase RIOK2.
Min Yu, Xiaoyan Hu, Jingyu Yan, Ying Wang, Fei Lu, Junlei Chang   +5 more
doaj   +1 more source

Blood–Brain Barrier Breakdown: An Emerging Biomarker of Cognitive Impairment in Normal Aging and Dementia

Frontiers in Neuroscience, 2021
The blood–brain barrier (BBB) plays a vital role in maintaining the specialized microenvironment of the neural tissue. It separates the peripheral circulatory system from the brain parenchyma while facilitating communication.
Basharat Hussain, Basharat Hussain, Cheng Fang, Junlei Chang   +3 more
doaj   +1 more source

Human Cytomegalovirus-Induced Degradation of CYTIP Modulates Dendritic Cell Adhesion and Migration

Frontiers in Immunology, 2017
As potent antigen-presenting cells, dendritic cells (DCs) are essential for the initiation of effective antiviral immune responses. Viruses and especially herpesviruses, which are able to establish lifelong persistence, exploit several immune evasion ...
Christiane S. Heilingloh, Linda Grosche, Christina Draßner, Petra Mühl-Zürbes, Lisa Kamm, Vu Thuy Khanh Le-Trilling, Mirko Trilling, Alexander Steinkasserer   +7 more
doaj   +1 more source

Effect of birth weight, exclusive breastfeeding and growth in infancy on fat mass and fat free mass indices in early adolescence: an analysis of the Entebbe Mother and Baby Study (EMaBs) cohort [version 2; peer review: 1 approved, 2 approved with reservations]

AAS Open Research, 2020
Background: There is limited data from Africa on the effect of pre- and post-natal growth and infant feeding on later body composition. This study's aim was to investigate the effect of birth weight, exclusive breastfeeding and infant growth on ...
Jonathan Nsamba, Swaib A. Lule, Benigna Namara, Christopher Zziwa, Hellen Akurut, Lawrence Lubyayi, Florence Akello, Josephine Tumusiime, Alison M. Elliott, Emily L. Webb   +9 more
doaj   +1 more source