Results 21 to 30 of about 74,853 (208)

AWP1 Restrains the Aggressive Behavior of Breast Cancer Cells Induced by TNF-α

Frontiers in Oncology, 2021
TNF-α plays a crucial role in cancer initiation and progression by enhancing cancer cell proliferation, survival, and migration. Even though the known functional role of AWP1 (zinc finger AN1 type-6, ZFAND6) is as a key mediator of TNF-α signaling, its ...
Eun-Young Kim, Eun-Young Kim, Ji-Eun Kim, Ji-Eun Kim, Bongkun Choi, Bongkun Choi, Jiyeon Kweon, Jiyeon Kweon, Si-On Park, Si-On Park, Hee-Seop Lee, Hee-Seop Lee, Eun-Jin Lee, Eun-Jin Lee, Soyoon Oh, Soyoon Oh, Ha Rim Shin, Ha Rim Shin, Hyuksu Choi, Hyuksu Choi, Yongsub Kim, Yongsub Kim, Eun-Ju Chang, Eun-Ju Chang, Eun-Ju Chang   +24 more
doaj   +1 more source

Immunomodulators for Asthma [PDF]

Allergy, Asthma and Immunology Research, 2010
New information regarding the molecular mechanisms of allergic disorders has led to a variety of novel therapeutic approaches. This article briefly reviews the pathogenesis of asthma and allergic diseases, discusses the rationale behind using immunomodulators in these diseases; and examines the therapeutic effects of immunomodulators on allergic ...
Thomas B. Casale, Vesselin Dimov
openaire   +3 more sources

Ethical and practical considerations arising from community consultation on implementing controlled human infection studies using Schistosoma mansoni in Uganda

Global Bioethics, 2022
Issues related to controlled human infection studies using Schistosoma mansoni (CHI-S) were explored to ensure the ethical and voluntary participation of potential CHI-S volunteers in an endemic setting in Uganda.
Moses Egesa, Agnes Ssali, Edward Tumwesige, Moses Kizza, Emmanuella Driciru, Fiona Luboga, Meta Roestenberg, Janet Seeley, Alison M. Elliott   +8 more
doaj   +1 more source

The Role of Immune Cells in Post-Stroke Angiogenesis and Neuronal Remodeling: The Known and the Unknown

Frontiers in Immunology, 2021
Following a cerebral ischemic event, substantial alterations in both cellular and molecular activities occur due to ischemia-induced cerebral pathology.
Yinzhong Ma, Shilun Yang, Qianyan He, Dianhui Zhang, Junlei Chang   +4 more
doaj   +1 more source

Unsupervised title and abstract screening for systematic review: a retrospective case-study using topic modelling methodology

Systematic Reviews, 2023
Background The importance of systematic reviews in collating and summarising available research output on a particular topic cannot be over-emphasized.
Agnes Natukunda, Leacky K. Muchene
doaj   +1 more source

Allergen Immunotherapy and Tolerance

Allergology International, 2013
Successful allergen-specific immunotherapy (AIT) is associated with a marked decrease in symptoms on allergen exposure, a reduced requirement for 'rescue' anti-allergic drugs and improvement in patients' quality of life.
Tomokazu Matsuoka, Mohamed H Shamji, Stephen R Durham   +2 more
doaj   +1 more source

Schistosome immunomodulators

PLOS Pathogens, 2021
Schistosomes are long lived, intravascular parasitic platyhelminths that infect >200 million people globally. The molecular mechanisms used by these blood flukes to dampen host immune responses are described in this review. Adult worms express a collection of host-interactive tegumental ectoenzymes that can cleave host signaling molecules such as ...
Sreemoyee Acharya, Akram A. Da’dara, Patrick J. Skelly   +2 more
openaire   +4 more sources

Effect of birth weight, exclusive breastfeeding and growth in infancy on fat mass and fat free mass indices in early adolescence: an analysis of the Entebbe Mother and Baby Study (EMaBs) cohort [version 1; peer review: 1 approved, 2 approved with reservations]

AAS Open Research, 2019
Background: There is limited data from Africa on the effect of pre- and post-natal growth and infant feeding on later body composition. This study's aim was to investigate the effect of birth weight, exclusive breastfeeding and infant growth on ...
Jonathan Nsamba, Swaib A. Lule, Benigna Namara, Christopher Zziwa, Hellen Akurut, Lawrence Lubyayi, Florence Akello, Josephine Tumusiime, Alison M. Elliott, Emily L. Webb   +9 more
doaj   +1 more source

Maternal Latent Mycobacterium tuberculosis Does Not Affect the Infant Immune Response Following BCG at Birth: An Observational Longitudinal Study in Uganda

Frontiers in Immunology, 2020
Background: BCG has low efficacy in tropical countries. We hypothesized that maternal latent Mycobacterium tuberculosis (M.tb) infection (LTBI) results in fetal tolerance to mycobacterial antigens and impaired responses to BCG immunization.Methods: We ...
Lawrence Lubyayi, Lawrence Lubyayi, Patrice A. Mawa, Patrice A. Mawa, Grace Nabakooza, Marjorie Nakibuule, John Vianney Tushabe, Joel Serubanja, Dorothy Aibo, Hellen Akurut, Josephine Tumusiime, Mateusz Hasso-Agopsowicz, Pontiano Kaleebu, Pontiano Kaleebu, Jonathan Levin, Hazel M. Dockrell, Steven Smith, Emily L. Webb, Alison M. Elliott, Alison M. Elliott, Stephen Cose, Stephen Cose   +21 more
doaj   +1 more source

Dissecting the role of CSF2RB expression in human regulatory T cells

Frontiers in Immunology, 2022
Colony stimulating factor 2 receptor subunit beta (CSF2RB; CD131) is the common subunit of the type I cytokine receptors for granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-3 and IL-5. Interestingly, FOXP3+ regulatory T cells (
Beatriz F. Côrte-Real, Beatriz F. Côrte-Real, Rebeca Arroyo Hornero, Rebeca Arroyo Hornero, Aleksandra Dyczko, Aleksandra Dyczko, Ibrahim Hamad, Ibrahim Hamad, Markus Kleinewietfeld, Markus Kleinewietfeld, Markus Kleinewietfeld   +10 more
doaj   +1 more source