Results 21 to 30 of about 79,221 (241)

Ethical and practical considerations arising from community consultation on implementing controlled human infection studies using Schistosoma mansoni in Uganda

Global Bioethics, 2022
Issues related to controlled human infection studies using Schistosoma mansoni (CHI-S) were explored to ensure the ethical and voluntary participation of potential CHI-S volunteers in an endemic setting in Uganda.
Moses Egesa, Agnes Ssali, Edward Tumwesige, Moses Kizza, Emmanuella Driciru, Fiona Luboga, Meta Roestenberg, Janet Seeley, Alison M. Elliott   +8 more
doaj   +1 more source

Maternal Latent Mycobacterium tuberculosis Does Not Affect the Infant Immune Response Following BCG at Birth: An Observational Longitudinal Study in Uganda

Frontiers in Immunology, 2020
Background: BCG has low efficacy in tropical countries. We hypothesized that maternal latent Mycobacterium tuberculosis (M.tb) infection (LTBI) results in fetal tolerance to mycobacterial antigens and impaired responses to BCG immunization.Methods: We ...
Lawrence Lubyayi, Lawrence Lubyayi, Patrice A. Mawa, Patrice A. Mawa, Grace Nabakooza, Marjorie Nakibuule, John Vianney Tushabe, Joel Serubanja, Dorothy Aibo, Hellen Akurut, Josephine Tumusiime, Mateusz Hasso-Agopsowicz, Pontiano Kaleebu, Pontiano Kaleebu, Jonathan Levin, Hazel M. Dockrell, Steven Smith, Emily L. Webb, Alison M. Elliott, Alison M. Elliott, Stephen Cose, Stephen Cose   +21 more
doaj   +1 more source

Contrasting impact of rural, versus urban, living on glucose metabolism and blood pressure in Uganda [version 2; peer review: 2 approved]

Wellcome Open Research, 2020
Background: The burden of cardiometabolic diseases, including cardiovascular diseases and diabetes, is increasing in sub-Saharan Africa and this has been linked to urbanisation.
Richard E. Sanya, Irene Andia Biraro, Margaret Nampijja, Christopher Zziwa, Carol Nanyunja, Denis Nsubuga, Samuel Kiwanuka, Josephine Tumusiime, Jacent Nassuuna, Bridgious Walusimbi, Stephen Cose, Ponsiano Ocama, Richard K. Grencis, Alison M. Elliott, Emily L. Webb   +14 more
doaj   +1 more source

Polydopamine-Mediated Protein Adsorption Alters the Epigenetic Status and Differentiation of Primary Human Adipose-Derived Stem Cells (hASCs)

Frontiers in Bioengineering and Biotechnology, 2022
Polydopamine (PDA) is a biocompatible cell-adhesive polymer with versatile applications in biomedical devices. Previous studies have shown that PDA coating could improve cell adhesion and differentiation of human mesenchymal stem cells (hMSCs).
Javad Harati, Javad Harati, Javad Harati, Xuelian Tao, Hosein Shahsavarani, Ping Du, Massimiliano Galluzzi, Kun Liu, Zhen Zhang, Zhen Zhang, Peter Shaw, Mohammad Ali Shokrgozar, Haobo Pan, Peng-Yuan Wang, Peng-Yuan Wang   +14 more
doaj   +1 more source

Functional systemic CD4 immunity is required for clinical responses to PD‐L1/PD‐1 blockade therapy

EMBO Molecular Medicine, 2019
The majority of lung cancer patients progressing from conventional therapies are refractory to PD‐L1/PD‐1 blockade monotherapy. Here, we show that baseline systemic CD4 immunity is a differential factor for clinical responses.
Miren Zuazo, Hugo Arasanz, Gonzalo Fernández‐Hinojal, Maria Jesus García‐Granda, María Gato, Ana Bocanegra, Maite Martínez, Berta Hernández, Lucía Teijeira, Idoia Morilla, Maria Jose Lecumberri, Angela Fernández de Lascoiti, Ruth Vera, Grazyna Kochan, David Escors   +14 more
doaj   +1 more source

Fast and Efficient Genome Editing of Human FOXP3+ Regulatory T Cells

Frontiers in Immunology, 2021
FOXP3+ regulatory T cells (Tregs) are central for maintaining peripheral tolerance and immune homeostasis. Because of their immunosuppressive characteristics, Tregs are a potential therapeutic target in various diseases such as autoimmunity ...
Lauren Van Zeebroeck, Lauren Van Zeebroeck, Rebeca Arroyo Hornero, Rebeca Arroyo Hornero, Beatriz F. Côrte-Real, Beatriz F. Côrte-Real, Ibrahim Hamad, Ibrahim Hamad, Torsten B. Meissner, Markus Kleinewietfeld, Markus Kleinewietfeld   +10 more
doaj   +1 more source

Development, Characterization, and Immunomodulatory Evaluation of Carvacrol-loaded Nanoemulsion

Molecules, 2021
Carvacrol (CV) is an essential oil with numerous therapeutic properties, including immunomodulatory activity. However, this effect has not been studied in nanoemulsion systems.
Amanda Gabrielle Barros Dantas, Rafael Limongi de Souza, Anderson Rodrigues de Almeida, Francisco Humberto Xavier Júnior, Maira Galdino da Rocha Pitta, Moacyr Jesus Barreto de Melo Rêgo, Elquio Eleamen Oliveira   +6 more
doaj   +1 more source

Divergent CD27 expression marks the Treg induction trajectory

Frontiers in Immunology
IntroductionThe induction of antigen-specific Tregs is explored as strategy to restore immune tolerance and halt progression of autoimmune diseases. However, the phenotypic changes in development of induced antigen specific Tregs in vivo have not been ...
Chelsea Gootjes, Maurits G. Staal, Diahann T. S. L. Jansen, Antoinette M. Joosten, Jaap Jan Zwaginga, Bart O. Roep, Tatjana Nikolic   +6 more
doaj   +1 more source

Bifidobacteria BbC50 Fermentation Products Induce Human Cd4 Regulatory T Cells with Antigen-Specific Activation and Bystander Suppression

European Journal of Inflammation, 2014
Probiotic bacteria have been shown to have health benefits in various situations (inflammation, allergy, infection). We previously showed that a bacteria-free fermentation product of Bifidobacterium breve C50 (BbC50sn) induced high IL-10 secretion by ...
L. Martin, A. Granier, R. Lemoine, A. Dauba, S. Vermeersch, C. Aubert-Jacquin, C. Baron, Y. Lebranchu, C. Hoarau, F. Velge-Roussel   +9 more
doaj   +1 more source

Ethnobotanical survey, anthelmintic effects and cytotoxicity of plants used for treatment of helminthiasis in the Central and Kara regions of Togo

BMC Complementary Medicine and Therapies, 2020
Background Traditional medicines are the main source of treatment of helminthiasis in endemic areas of Togo. The present study aimed to investigate the plants used by Traditional healers (THs) to treat helminth infections in endemic communities within ...
Essoham Ataba, Gnatoulma Katawa, Manuel Ritter, Adjoa Holali Ameyapoh, Kokou Anani, Oukoe M. Amessoudji, Pélagie Edlom Tchadié, Tchadjabo Tchacondo, Komlan Batawila, Yaovi Ameyapoh, Achim Hoerauf, Laura E. Layland, Simplice D. Karou   +12 more
doaj   +1 more source