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Immunosenescence and lymphomagenesis [PDF]

Immunity & Ageing, 2018
One of the most important determinants of aging-related changes is a complex biological process emerged recently and called “immunosenescence”. Immunosenescence refers to the inability of an aging immune system to produce an appropriate and effective ...
Salvatrice Mancuso, Melania Carlisi, Marco Santoro, Mariasanta Napolitano, Simona Raso, Sergio Siragusa   +5 more
doaj   +7 more sources

Immunosenescence in Caenorhabditis elegans

Immunity & Ageing, 2022
Immunosenescence is an age-dependent decline in immune functions and hallmark of aging in diverse species, ranging from invertebrates to mammals. However, identifying the factors responsible for immunosenescence is challenging because of the complexity ...
Sieun S. Kim, Jooyeon Sohn, Seung-Jae V. Lee   +2 more
doaj   +3 more sources

Immunosenescence in aging and neurodegenerative diseases: evidence, key hallmarks, and therapeutic implications [PDF]

Translational Neurodegeneration
Aging is a multifaceted biological process affecting various organ systems. Immunosenescence, a key feature of aging, markedly increases susceptibility to infections, cancers, autoimmune diseases, and also neurodegenerative disorders.
Zhichun Chen, Zixu Mao, Weiting Tang, Yuxuan Shi, Jun Liu, Yong You   +5 more
doaj   +2 more sources

The pathophysiological mechanisms of immunosenescence in coronary artery disease [PDF]

Frontiers in Cell and Developmental Biology
Coronary artery disease (CAD) is the most common coronary heart disease, characterized by the accumulation of atherosclerotic plaques in the coronary arteries, which supply oxygen and nutrients to the heart.
Hengjie Bie, Zhengxian Tao
doaj   +2 more sources

Bacterial Quorum-Sensing Peptides as Immune Modulators Present in Systemic Circulation

Biomolecules, 2023
Quorum-sensing peptides (QSPs) are bacterial peptides traditionally considered only as inter-bacterial communication molecules. Recently, their involvement in microbiome–host interactions influencing host diseases such as cancer and sarcopenia were ...
Anton De Spiegeleer, Amélie Descamps, Srinath Govindarajan, Julie Coudenys, Kevin Van der borght, Hannah Hirmz, Nele Van Den Noortgate, Dirk Elewaut, Bart De Spiegeleer, Evelien Wynendaele   +9 more
doaj   +1 more source

Immunopathology and Immunosenescence, the Immunological Key Words of Severe COVID-19. Is There a Role for Stem Cell Transplantation?

Frontiers in Cell and Developmental Biology, 2021
The outcomes of Coronavirus disease-2019 (COVID-19) vary depending on the age, health status and sex of an individual, ranging from asymptomatic to lethal.
Mattia Emanuela Ligotti, Mattia Emanuela Ligotti, Fanny Pojero, Giulia Accardi, Anna Aiello, Calogero Caruso, Calogero Caruso, Giovanni Duro, Giuseppina Candore   +8 more
doaj   +1 more source

The immunosenescence-related factor DOCK11 is involved in secondary immune responses of B cells

Immunity & Ageing, 2022
Background Memory B cells are an antigen-experienced B-cell population with the ability to rapidly differentiate into antibody-producing cells by recall responses.
Yuma Sugiyama, Mitsuhiro Fujiwara, Akihiko Sakamoto, Hiromichi Tsushima, Akihiko Nishikimi, Mitsuo Maruyama   +5 more
doaj   +1 more source

Immunosenescence: A Critical Factor Associated With Organ Injury After Sepsis

Frontiers in Immunology, 2022
Progressive immune dysfunction associated with aging is known as immunosenescence. The age-related deterioration of immune function is accompanied by chronic inflammation and microenvironment changes.
Xuan Lu, Xuan Lu, Yun-Mei Yang, Yun-Mei Yang, Yuan-Qiang Lu, Yuan-Qiang Lu   +5 more
doaj   +1 more source

Elucidation of the role of nucleolin as a cell surface receptor for nucleic acid-based adjuvants

npj Vaccines, 2022
Nucleic acid-based adjuvants such as CpG oligonucleotides (CpG ODNs) and poly(I:C) are potential vaccine adjuvants for infectious diseases and cancers. However, the mechanism by which their cell surface receptors promote their uptake into dendritic cells
Satoki Kitagawa, Teppei Matsuda, Ayaka Washizaki, Hirotomo Murakami, Takuya Yamamoto, Yasuo Yoshioka   +5 more
doaj   +1 more source

Nutrition, diet and immunosenescence [PDF]

, 2013
Ageing is characterized by immunosenescence and the progressive decline in immunity in association with an increased frequency of infections and chronic disease.
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core   +1 more source