Regulatory RNAs in immunosenescence
Immunity, Inflammation and DiseaseBackground Immunosenescence is a multifactorial stress response to different intrinsic and extrinsic insults that cause immune deterioration and is accompanied by genomic or epigenomic perturbations.
Atefe Ghamar Talepoor +1 more
doaj +3 more sources
Imaging Immunosenescence [PDF]
, 2015 To demonstrate effects of aging visually requires a robust technique that can reproducibly detect small differences in efficiency or kinetics between groups. Investigators of aging will greatly appreciate the benefits of Amnis ImageStream technology ( www.amnis.com/), which combines quantitative flow cytometry with simultaneous high-resolution digital ...
Feng, Qian, Ruth R, Montgomery
openaire +2 more sources
Bibliometric and visualization analysis of global research trends on immunosenescence (1970–2021)
Experimental Gerontology, 2023 Background: Immunosenescence, the aging of the immune system, leads to a decline in the body's adaptability to the environment and plays an important role in various diseases. Immunosenescence has been widely studied in recent years. However, to date, no
Yao Tan +7 more
doaj +1 more source
System Dynamics Modelling of the Processes Involving the Maintenance of the Naive T Cell Repertoire [PDF]
, 2009 The study of immune system aging, i.e. immunosenescence, is a relatively new research topic. It deals with understanding the processes of immunodegradation that indicate signs of functionality loss possibly leading to death.
Aickelin, Uwe +2 more
core +3 more sources
Modeling of Immunosenescence and Risk of Death from Respiratory Infections: Evaluation of the Role of Antigenic Load and Population Heterogeneity [PDF]
, 2017 It is well known that efficacy of immune functions declines with age. It results in an increase of severity and duration of respiratory infections and also in dramatic growth of risk of death due to these diseases after age 65.
Barbi, Elisabetta +5 more
core +1 more source
AGE, 2005 Immunosenescence, the aging of the immune system, is well studied in humans. Mammalian immune systems become less capable of fighting pathogens and individuals become more susceptible to infection and cancer in their elder years. Little is currently published on avian immunosenescence even though avian immune function has been well characterized and ...
openaire +2 more sources
The impact of senescence-associated T cells on immunosenescence and age-related disorders
Inflammation and Regeneration, 2018 Immunosenescence is age-associated changes in the immunological functions, including diminished acquired immunity against infection, pro-inflammatory traits, and increased risk of autoimmunity.
Yuji Fukushima +2 more
doaj +1 more source
Immunosenescence: molecular mechanisms and diseases
Signal Transduction and Targeted Therapy, 2023 Infection susceptibility, poor vaccination efficacy, age-related disease onset, and neoplasms are linked to innate and adaptive immune dysfunction that accompanies aging (known as immunosenescence).
Zaoqu Liu +9 more
doaj +1 more source
Beyond Cholinesterase Inhibition. Anti-Inflammatory Role and Pharmacological Profile of Current Drug Therapy for Alzheimer's Disease [PDF]
, 2016 Inflammation is a common response of an individual against either exogenous or endogenous damage. The role of inflammation and of inflammatory cells recently emerged also in the pathogenesis of neurodegenerative disorders. Experimental evidences show how
GIUBILEI, Franco
core +1 more source
Accelerated aging in perinatally HIV-infected children: clinical manifestations and pathogenetic mechanisms [PDF]
, 2018 BACKGROUND: Premature aging and related diseases have been documented in HIV-infected adults. Data are now emerging also regarding accelerated aging process in HIV-infected children. METHODS: A narrative review was performed searching studies on PubMed
Bianconi, Martina +6 more
core +1 more source