Results 31 to 40 of about 29,033 (245)
Frontiers in Immunology, 2019 Aging is accompanied by remodeling of the immune system. With time, this leads to a decline in immune efficacy, resulting in increased vulnerability to infectious diseases, diminished responses to vaccination, and a susceptibility to age-related ...
Anna Aiello +9 more
doaj +1 more source
Mediators of Inflammation, 2020 Extracellular matrix metalloproteinases (MMPs) are a group of proteins that activate substrates by enzymatic cleavage and, on the basis of their activities, have been demonstrated to play a role in ageing.
Patrizia Cancemi +10 more
doaj +1 more source
Immunosenescence of ageing [PDF]
The Journal of Pathology, 2007 AbstractAgeing is a complex process that negatively impacts the development of the immune system and its ability to function. The mechanisms that underlie these age‐related defects are broad and range from defects in the haematopoietic bone marrow to defects in peripheral lymphocyte migration, maturation and function.
A L, Gruver, L L, Hudson, G D, Sempowski
openaire +2 more sources
Myocardial Ischemia and Reperfusion Leads to Transient CD8 Immune Deficiency and Accelerated Immunosenescence in CMV-Seropositive Patients [PDF]
, 2014 Rationale: There is mounting evidence of a higher incidence of coronary heart disease (CHD) in cytomegalovirus (CMV) seropositive individuals. Objective: The aim of this study was to investigate whether acute MI triggers an inflammatory T-cell ...
Bagnall, Alan +14 more
core +1 more source
A dose-ranging study in older adults to compare the safety and immunogenicity profiles of MF59®-adjuvanted and non-adjuvanted seasonal influenza vaccines following intradermal and intramuscular administration [PDF]
, 2014 Strategies to optimize responses to seasonal influenza vaccination in older adults include the use of adjuvants, higher antigen doses, and intradermal delivery.
Castellino, Flora +9 more
core +1 more source
Immunosenescence and cancer [PDF]
Critical Reviews in Oncology/Hematology, 2010 Age is a major risk factor for many cancers. Although this is usually viewed in the context of the cell biology, we argue here that age-associated changes to immunity may also contribute to the age-associated increasing incidence of most cancers. This is because cancers are immunogenic (at least initially), and the immune system can and does protect ...
Graham, Pawelec +2 more
openaire +2 more sources
Caenorhabditis elegans and probiotics interactions from a prolongevity perspective [PDF]
, 2019 Probiotics exert beneficial effects on host health through different mechanisms of action, such as production of antimicrobial substances, competition with pathogens, enhancement of host mucosal barrier integrity and immunomodulation.
Barbara Guantario +5 more
core +1 more source
Experimental Gerontology, 2023 Senescent cells were recently shown to play a role in aging-related malfunctions and pathologies. This consensus has been facilitated by evidence from senolytic model mice capable of eliminating senescent cells in tissues using well-characterized ...
Yuma Sugiyama +6 more
doaj +1 more source
Evolution of the G+C content frontier in the rat cytomegalovirus genome [PDF]
, 2008 Within the 230138 bp of the rat cytomegalovirus (RCMV) genome, the G+C content changes abruptly at position 142644, constituting a G+C content frontier. To the left of this point, overall G+C content is 69.2%, and to the right it is only 47.6%.
Gatherer, Derek
core +3 more sources
Global research trends of immunosenescence: A bibliometric study
Heliyon, 2023 Background: Immunosenescence, an age-related deficit in immunity, associated with multiple disorders and making the successful aging a challenge. Although nearly 4000 articles have been published, only few review articles have summarized the research ...
Hongbo Chen +6 more
doaj +1 more source