Results 61 to 70 of about 29,033 (245)

Ultrasmall Fe‐curcumin immunomodulators reinvigorate CAR‐T cells to potentiate solid tumor immunotherapy by mitigating cell exhaustion and senescence

BMEMat, EarlyView.
This work discovered a novel research that ultrasmall Fe‐curcumin immunomodulators could reinvigorate CAR‐T cells to potentiate solid tumor immunotherapy by mitigating cell exhaustion and senescence. Abstract CAR‐T cell immunotherapy has achieved exciting success in hematologic malignancies, but the therapeutic efficacy is relatively limited in solid ...
Jiazhi Duan, Yuchan Xue, Miao Zhang, Zihao Zhang, Shiyu Peng, Minghao Sui, Han Ding, Yingying Nie, Yuemin Feng, Le Wang, Tianru Zhang, Mingchuan Yu, He Xia, Hong Liu, Qiang Zhu, Songbo Zhao   +15 more
wiley   +1 more source

Centenarians, semi and supercentenarians, COVID-19 and Spanish flu: a serological assessment to gain insight into the resilience of older centenarians to COVID-19

Immunity & Ageing
Background Although it is well known that the older people have been the most susceptible to COVID-19, there are conflicting data on the susceptibility of centenarians.
Claudia Maria Trombetta, Giulia Accardi, Anna Aiello, Anna Calabrò, Calogero Caruso, Mattia Emanuela Ligotti, Serena Marchi, Emanuele Montomoli, Martin Mayora Neto, Nigel Temperton, Giuseppina Candore   +10 more
doaj   +1 more source

Stress and Exercise [PDF]

, 2007
Age-related immunological and endocrinological changes may have implications for resilience to stress in older adults. We hypothesise that the combination of adrenopause and immunesenescence may leave this population particularly vulnerable to the ...
Bauer, Butcher, Butcher, Butcher, Emery, Fleshner, Globerson, Graham, Hawkley, Kemmler, Kiecolt-Glaser, Kohut, Kohut, Kohut, Leveille, O'Donnell, Ogata, Orentreich, Phillips, Segerstrom, Vedhara, Vedhara   +21 more
core   +1 more source

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, EarlyView.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

Trends in Rheumatoid Arthritis Mortality Among Postmenopausal Women in the United States, 1999–2023

iMetaMed, EarlyView.
RA‐related mortality among U.S. postmenopausal women has markedly declined since 1999. Despite this overall progress, significant inequalities by race, region, and age highlight ongoing challenges in achieving equitable health outcomes. ABSTRACT Rheumatoid arthritis (RA) disproportionately affects postmenopausal women, who are at an increased risk of ...
Yuhui Zhao, Weilu Cui, Yayun Han, Jun Qiao, Minjing Chang   +4 more
wiley   +1 more source

Immunosenescence: signaling pathways, diseases and therapeutic targets

Signal Transduction and Targeted Therapy
Immunosenescence refers to the abnormal activation or dysfunction of the immune system as people age. Inflammaging is a typical pathological inflammatory state associated with immunosenescence and is characterized by excessive expression of ...
Yichu Fu, Binhan Wang, Aqu Alu, Weiqi Hong, Hong Lei, Xuemei He, Huashan Shi, Ping Cheng, Xiangliang Yang   +8 more
doaj   +1 more source

Immunosenescence and Cytomegalovirus: where do we stand after a decade? [PDF]

, 2010
Since Looney at al. published their seminal paper a decade ago it has become clear that many of the differences in T cell immunological parameters observed between young and old people are related to the age-associated increasing prevalence of infection ...
Graham Pawelec, Arne Akbar, Peter Beverley, Calogero Caruso, Evelyna Derhovanessian, Tamas Fülöp, Paul Griffiths, Beatrix Grubeck-Loebenstein, Klaus Hamprecht, Gerhard Jahn, Florian Kern, Sven D Koch, Anis Larbi, Andrea B Maier, Derek Macallan, Paul Moss, Sandrine Samson, Jan Strindhall, Emanuelle Trannoy, Mark Wills   +19 more
core   +3 more sources

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

iNew Medicine, EarlyView.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng, Qianqian Wang, Jiachen Zhang, Sandra Chiu   +3 more
wiley   +1 more source

Targeting immunosenescence for improved tumor immunotherapy

MedComm
Tumor immunotherapy has significantly transformed the field of oncology over the past decade. An optimal tumor immunotherapy would ideally elicit robust innate and adaptive immune responses within tumor immune microenvironment (TIME).
Zaoqu Liu, Lulu Zuo, Zhaokai Zhou, Shutong Liu, Yuhao Ba, Anning Zuo, Yuqing Ren, Chuhan Zhang, Yukang Chen, Hongxuan Ma, Yudi Xu, Peng Luo, Quan Cheng, Hui Xu, Yuyuan Zhang, Siyuan Weng, Xinwei Han   +16 more
doaj   +1 more source

Immune-Inflammatory Response in Lifespan—What Role Does It Play in Extreme Longevity? A Sicilian Semi- and Supercentenarians Study

Biology
Studying models of healthy aging and exceptional longevity is crucial to understanding a possible longevity signature, as most show resistance to age-related diseases.
Giulia Accardi, Anna Calabrò, Rosalia Caldarella, Calogero Caruso, Marcello Ciaccio, Marta Di Simone, Mattia Emanuela Ligotti, Serena Meraviglia, Rosa Zarcone, Giuseppina Candore, Anna Aiello   +10 more
doaj   +1 more source