Results 141 to 150 of about 174,772 (308)

TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition

open access: yesAdvanced Science, EarlyView.
This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Yanchen Zhang   +16 more
wiley   +1 more source

The relationship between cumulative dose of immunosuppressive agents and COVID-19-associated mucormycosis: A multicenter cross-sectional study. [PDF]

open access: yesHealth Sci Rep, 2022
Rastkar M   +9 more
europepmc   +1 more source

tRNA‐Derived Fragment tRF‐22 Promotes Immunosuppression by Inhibiting HnRNPAB Ubiquitination in Esophageal Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
tRF‐22 fosters an immunosuppressive and pro‐oncogenic tumor microenvironment in ESCC by stabilizing hnRNPAB against TRIM25‐mediated ubiquitination and enhancing TGFβ2 expression, which increases PMN‐MDSCs infiltration and suppresses CD8+ T cells. Targeting tRF‐22 or blocking TGFβ signalling improves anti‐PD1 response, offering a promising therapeutic ...
Ling Pan   +10 more
wiley   +1 more source

Toxoplasmosis in patients with an autoimmune disease and immunosuppressive agents: A multicenter study and literature review. [PDF]

open access: yesPLoS Negl Trop Dis, 2022
Durieux MF   +24 more
europepmc   +1 more source

FK506 VERSUS CYCLOSPORINE AS PRIMARY IMMUNOSUPPRESSIVE AGENT FOR ORTHOTOPIC LIVER ALLOGRAFT RECIPIENTS HISTOLOGIC AND IMMUNOPATHOLOGIC OBSERVATIONS1

open access: bronze, 1993
Prodromos Hytiroglou   +6 more
openalex   +1 more source

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