The monoclonal antibody nBT062 conjugated to maytansinoids has potent and selective cytotoxicity against CD138 positive multiple myeloma cells _in vitro_ and _in vivo_ [PDF]
, 2008 CD138 (Syndecan1) is highly expressed on multiple myeloma (MM) cells. In this study, we examined the anti-MM effect of murine/human chimeric CD138-specific monoclonal antibody (mAb) nBT062 conjugated with highly cytotoxic maytansinoid derivatives _in ...
Benjamin Dä +20 more
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Frontiers in Oncology, 2016 Glycolipids are complex molecules consisting of a ceramide lipid moiety linked to a glycan chain of variable length and structure. Among these are found the gangliosides, which are sialylated glycolipids ubiquitously distributed on the outer layer of ...
Jose Luis Daniotti +2 more
doaj +1 more source
Codominance and toxins: A path to drugs of nearly unlimited selectivity [PDF]
, 1995 The effectiveness of drugs is often limited by their insufficient selectivity. I propose designs of therapeutic agents that address this problem. The key feature of these reagents, termed comtoxins (codominance-mediated toxins), is their ability to ...
Varshavsky, Alexander
core
Hairy cell leukemia, an uncommon B-cell lymphoid neoplasia [PDF]
, 2016 Hairy cell leukemia (HCL) is an uncommon B-cell lymphoid neoplasia, representing 2---3% of all leukemias. It is more common in men, with a median age at diagnosis of 52 years.
Garza Ledezma, María Alejandra +3 more
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Tailoring Immunotoxin AS Anticancer Drug [PDF]
, 1989 The conventional treatments for cancer have been considered unsatisfatory, with limited efficiency in terms of discriminative cancer cell adverse reaction against the normal compartments, a number of immunological approaches had been implemented.
Asikin, N. (Nur) +6 more
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Getting over a hangover : how do wake promoting neurons in the basal forebrain affect ethanol induced sleep? [abstract] [PDF]
, 2010 Hangover is a common clinical manifestation of heavy alcohol use. Sleepiness/drowsiness is a common symptom of hangover; however its neuroanatomical substrate is unknown.
deRoode, David +2 more
core
Rituximab synergizes with hydroxyurea or vincristine in the killing of Ramos Burkitt's lymphoma B cell line [PDF]
, 2014 Abulayha, Abdulmunem +6 more
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Modulation of transforming growth factor-beta signaling transducers in colon adenocarcinoma cells induced by staphylococcal enterotoxin B [PDF]
, 2016 Colorectal cancer (CRC) is a notable cause of cancer-associated mortality worldwide, making it a pertinent topic for the study of cancer and its treatment.
Akbari, Abolfazl. +5 more
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Citation: 'immunotoxin' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13326 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire +1 more source
Cooperative research and development opportunities with the National Cancer Institute [PDF]
The Office of Technology Development (OTD) of the National Cancer Institute (NCI) is responsible for negotiating Cooperative Research and Development Agreements (CRADAs), whereby the knowledge resulting from NCI investigators' government-sponsored ...
Sybert, Kathleen
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