Results 91 to 100 of about 9,896 (218)
BioMed Research International, Volume 2026, Issue 1, 2026.Ricin, a potent ribosome‐inactivating protein derived from the seeds of Ricinus communis L., represents a significant threat in the context of biological warfare and terrorism due to its high toxicity, ease of extraction, and lack of a specific antidote.
Miroslav Pohanka +1 more
wiley +1 more source
Bacterial Toxins for Cancer Therapy
Toxins, 2017 Several pathogenic bacteria secrete toxins to inhibit the immune system of the infected organism. Frequently, they catalyze a covalent modification of specific proteins. Thereby, they block production and/or secretion of antibodies or cytokines. Moreover,
Nour-Imene Zahaf, Gudula Schmidt
doaj +1 more source
Tailoring Immunotoxin AS Anticancer Drug [PDF]
, 1989 The conventional treatments for cancer have been considered unsatisfatory, with limited efficiency in terms of discriminative cancer cell adverse reaction against the normal compartments, a number of immunological approaches had been implemented.
Asikin, N. (Nur) +6 more
core
Secondary Necrosis Following Caspase‐Activation can Occur Independently of Gasdermin E
Advanced Science, Volume 12, Issue 46, December 11, 2025.Secondary necrosis follows apoptosis, but its mechanism is unclear. This study shows that although gasdermin E is cleaved during this process, it is not required for membrane rupture. Across multiple models, secondary necrosis occurred regardless of gasdermin E presence, challenging prior claims and redefining the understanding of how apoptotic cells ...
Shubhangi Gavali +9 more
wiley +1 more source
Antibodies, 2013 Elucidating the intracellular fate(s) of targeted toxins is of fundamental importance for their optimal use as anticancer drugs, since the biochemical targets of their enzymatic activity reside in the cell cytoplasm, as in the case of the plant ribosome ...
Maria Serena Fabbrini +6 more
doaj +1 more source
Immuno-targeting the multifunctional CD38 using nanobody [PDF]
, 2016 published_or_final_versio
Deng, QW +14 more
core +1 more source
Retinal waves are unlikely to instruct the formation of eye-specific retinogeniculate projections [PDF]
, 2009 In all mammalian species the projections of the two eyes to the dorsal lateral geniculate nucleus are initially overlapping before gradually forming the eye-specific domains evident at maturity.
Leo M Chalupa
core +2 more sources
Fungal Ribotoxins: A Review of Potential Biotechnological Applications
Toxins, 2017 Fungi establish a complex network of biological interactions with other organisms in nature. In many cases, these involve the production of toxins for survival or colonization purposes. Among these toxins, ribotoxins stand out as promising candidates for
Miriam Olombrada +8 more
doaj +1 more source
Ochratoxin A: In Utero Exposure in Mice Induces Adducts in Testicular DNA [PDF]
, 2010 Ochratoxin A (OTA) is a nephrotoxin and carcinogen that is associated with Balkan endemic nephropathy and urinary tract tumors. OTA crosses the placenta and causes adducts in the liver and kidney DNA of newborns.
Jamie E. Jennings-Gee +52 more
core +3 more sources
ROR1, an embryonic protein with an emerging role in cancer biology [PDF]
, 2014 Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a member of the ROR family consisting of ROR1 and ROR2. RORs contain two distinct extracellular cysteine-rich domains and one transmembrane domain. Within the intracellular portion, ROR1 possesses
David Kusner +3 more
core +1 more source