Results 91 to 100 of about 6,038 (211)

Pentostatin Plus Cyclophosphamide Safely and Effectively Prevents Immunotoxin Immunogenicity in Murine Hosts

, 2011
Purpose: The success of immunotoxin therapy of cancer is limited by host production of neutralizing antibodies, which are directed toward the Pseudomonas exotoxin A (PE) component.
Ira Pastan, Daniel H. Fowler, Justin Taylor, Shirin Treadwell, Raffit Hassan, Masanori Onda, Paul R. Massey, Miriam E. Mossoba, Elad Sharon   +8 more
core   +1 more source

Immunotoxin Therapies for the Treatment of Epidermal Growth Factor Receptor-Dependent Cancers

Toxins, 2016
Many epithelial cancers rely on enhanced expression of the epidermal growth factor receptor (EGFR) to drive proliferation and survival pathways. Development of therapeutics to target EGFR signaling has been of high importance, and multiple examples have ...
Nathan Simon, David FitzGerald
doaj   +1 more source

TAILORING IMMUNOTOXIN AS ANTICANCER DRUG

, 2012
The conventional treatments for cancer have been considered unsatisfatory, with limited efficiency in terms of discriminative cancer cell adverse reaction against the normal compartments, a number of immunological approaches had been implemented.
Huda, Nur; Research Center for Medical Science and Technology, Medical School, University of Indonesia, Asikin, Nur; Research Center for Medical Science and Technology, Medical School, University of Indonesia, Suryana, Enud J.; Research Center for Medical Science and Technology, Medical School, University of Indonesia, Baziad, Ali; Research Center for Medical Science and Technology, Medical School, University of Indonesia, Cornain, Santoso; Research Center for Medical Science and Technology, Medical School, University of Indonesia, Hambali, Hambali; Research Center for Medical Science and Technology, Medical School, University of Indonesia, Azis, Farid; Research Center for Medical Science and Technology, Medical School, University of Indonesia   +6 more
core   +1 more source

Targeted Apoptosis Activation with GrB/scFvMEL Modulates Melanoma Growth, Metastatic Spread, Chemosensitivity, and Radiosensitivity

Neoplasia: An International Journal for Oncology Research, 2006
GrB/scFvMEL, a fusion protein composed of human granzyme B (GrB) and the single-chain antibody scFvMEL, targets melanoma gp240 antigen and exerts impressive cytotoxic effects by inducing apoptosis. We evaluated the effects of GrB/scFvMEL on chemotherapy,
Yuying Liu, Weihe Zhang, Ting Niu, Lawrence H. Cheung, Anupama Munshi, Raymond E. Meyn, Jr., Michael G. Rosenblum   +6 more
doaj   +1 more source

Interactions Between Pseudomonas Immunotoxins and the Plasma Membrane: Implications for CAT-8015 Immunotoxin Therapy

Frontiers in Oncology, 2018
Acute Lymphoblastic Leukemia (ALL) remains the most frequent cause of cancer-related mortality in children and novel therapies are needed for the treatment of relapsed/refractory childhood ALL.
Monika Bokori-Brown, Jeremy Metz, Peter G. Petrov, Francis Mussai, Carmela De Santo, Neil J. Smart, Sarah Saunders, Bridget Knight, Ira Pastan, Richard W. Titball, C. Peter Winlove   +10 more
doaj   +1 more source

Supplementary Methods, Supplementary Figures 1-5, and Supplementary Tables 1-2 from Targeted Cytolysins Synergistically Potentiate Cytoplasmic Delivery of Gelonin Immunotoxin

, 2013
PDF file- 129 KB, Supplementary Methods; Supplementary Figure S1: Potentiator binding and cytotoxicity; Supplementary Figure S2: Potentiator hemolytic activity; Supplementary Figure S3: Potentiation of gelonin immunotoxin cytotoxicity; Supplementary ...
K. Dane Wittrup (1294554), Christopher M. Pirie (15066897), David V. Liu (1593601)   +2 more
core   +1 more source

Toxicity Profile of eBAT, a Bispecific Ligand-Targeted Toxin Directed to EGFR and uPAR, in Mice and a Clinical Dog Model

Toxins
EGFR-targeted therapies are efficacious, but toxicity is common and can be severe. Urokinase type plasminogen activator receptor (uPAR)-targeted drugs are only emerging, so neither their efficacy nor toxicity is fully established.
Rose H. Dicovitsky, Jill T. Schappa, Ashley J. Schulte, Haeree P. Lang, Ellen Kuerbitz, Sarah Roberts, Taylor A. DePauw, Mitzi Lewellen, Amber L. Winter, Kathy Stuebner, Michelle Buettner, Kelly Reid, Kelly Bergsrud, Sara Pracht, Andrea Chehadeh, Caitlin Feiock, M. Gerard O’Sullivan, Tim Carlson, Alexandra R. Armstrong, Danielle Meritet, Michael S. Henson, Brenda J. Weigel, Jaime F. Modiano, Antonella Borgatti, Daniel A. Vallera   +24 more
doaj   +1 more source

Immunotoxin-mediated targeting of claudin-4 inhibits the proliferation of cancer cells

, 2013
Immunotoxins are engineered chimeric proteins that consist of a fragment of a toxin fused to a modified antibody or growth factor capable of targeting specific cells.
Wei, MQ, Alqurashi, N, Ipe, DS, Hashimi, SM, Yu, S   +4 more
core   +1 more source

Development of an immunotoxin incorporating the Australian jumper ant toxin, pilosulin 1 [PDF]

, 2007
University of Technology, Sydney. Faculty of Science.Immunotoxins are therapeutic agents that directly target toxins to specific cells and are generally comprised of an antibody or antibody fragment (Fab or scFv) linked to a toxic moiety.
Lemke, Susan Jane
core  

Supplementary Figure 2 from Efficacy of RG7787, a Next-Generation Mesothelin-Targeted Immunotoxin, against Triple-Negative Breast and Gastric Cancers

, 2014
Supplementary Figure 2.
Gerhard Niederfellner (107798), Laiman Xiang (14982983), Christine Alewine (614463), Klaus Bosslet (3021141), Takao Yamori (704541), Ira Pastan (303807)   +5 more
core   +1 more source