Results 71 to 80 of about 6,607 (210)

Pore-Forming Proteins from Cnidarians and Arachnids as Potential Biotechnological Tools

Toxins, 2019
Animal venoms are complex mixtures of highly specialized toxic molecules. Cnidarians and arachnids produce pore-forming proteins (PFPs) directed against the plasma membrane of their target cells.
Esperanza Rivera-de-Torre, Juan Palacios-Ortega, José G. Gavilanes, Álvaro Martínez-del-Pozo, Sara García-Linares   +4 more
doaj   +1 more source

Correspondence of Basal Forebrain Resting‐State Functional Connectivity and Cerebral Glucose Metabolism Alterations With Neurotransmitter Maps in Alzheimer's Disease

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
Altered functional connectivity of basal forebrain subregions (Ch1‐3, Ch4) and widespread cerebral hypometabolism were identified in Alzheimer's disease using simultaneous PET/MRI. Spatial correspondence with normative neurotransmitter receptor and transporter maps suggested that serotonergic and dopaminergic systems may contribute to AD‐related ...
Yujie He, Hanxiao Xue, Sheng Bi, Yan Wang, Xiaocao Liu, Yixia Li, Zhigeng Chen, Dongdong Rong, Bixiao Cui, Jie Ma, Shaozhen Yan, Jie Lu   +11 more
wiley   +1 more source

Mechanism of triterpenoid saponin mediated augmentation of saporin based immunotoxin cytotoxicity

, 2019
Immunotoxins are hybrid molecules comprised of a protein toxin molecule and a monoclonal antibody that selectively delivers the toxin to antigen expressing cells.
Wensley, Harrison James
core   +1 more source

Antiviral Immunotoxin Against Bovine herpesvirus-1: Targeted Inhibition of Viral Replication and Apoptosis of Infected Cell

Frontiers in Microbiology, 2018
Bovine herpesvirus 1 (BoHV-1) is a highly contagious viral pathogen which causes infectious bovine rhinotracheitis in cattle worldwide. Currently, there is no antiviral prophylactic treatment available capable of mitigating the disease impact and ...
Jian Xu, Jian Xu, Xiaoyang Li, Xiaoyang Li, Xiaoyang Li, Bo Jiang, Bo Jiang, Xiaoyu Feng, Jing Wu, Jing Wu, Jing Wu, Yunhong Cai, Yunhong Cai, Xixi Zhang, Xixi Zhang, Xiufen Huang, Xiufen Huang, Joshua E. Sealy, Munir Iqbal, Yongqing Li, Yongqing Li   +20 more
doaj   +1 more source

Mechanistic Insights Into Photocatalytic Materials for Toxic Pollutants: Environmental Remediation of Personal Care Products

Asia-Pacific Journal of Chemical Engineering, Volume 21, Issue 2, March/April 2026.
ABSTRACT Photocatalytic materials have emerged as promising solutions for environmental applications due to their ability to degrade organic pollutants under sunlight or artificial light. In this review, recent progress on the photocatalytic materials used for the degradation of pharmaceutical personal care products (PPCPs) in environmental ...
Urvashi Sen, Gunjan Chauhan, Surbhi Soni, Monika Vats, Anand Kumar, Indra Bahadur   +5 more
wiley   +1 more source

A novel bispecific immunotoxin delivered by human bone marrow-derived mesenchymal stem cells to target blood vessels and vasculogenic mimicry of malignant gliomas

, 2015
Yonghong Zhang,1,2 Xinlin Sun,1 Min Huang,1 Yiquan Ke,1 Jihui Wang,1 Xiao Liu1 1National Key Clinic Specialty, Neurosurgery Institute of Guangdong Province, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of ...
Ke Y, Liu X, Zhang Y, Huang M, Sun X, Wang J   +5 more
core  

A Phase I study of an intravesically administered immunotoxin targeting EpCAM for the treatment of nonmuscle-invasive bladder cancer in BCG-refractory and BCG-intolerant patients [PDF]

, 2010
Mark Kowalski1, Joycelyn Entwistle2, Jeannick Cizeau2, Demi Niforos1, Shauna Loewen2, Wendy Chapman1, Glen C MacDonald21Viventia Biotechnologies Inc., Mississauga, ON, Canada; 2Viventia Biotechnologies Inc., Winnipeg, MB, CanadaPurpose: A Phase I dose ...
Mark Kowalski, null Jocelyn Entwistle, Joycelyn Entwistle, null Mark Kowalski, Jeannick Cizeau, null Jeannick Cizeau, et al, null Shauna Loewen, null Wendy Chapman, null Demi Niforos, null MacDonald   +10 more
core   +1 more source

Engineering of Ribosome-inactivating Proteins for Improving Pharmacological Properties

Toxins, 2020
Ribosome-inactivating proteins (RIPs) are N-glycosidases, which depurinate a specific adenine residue in the conserved α-sarcin/ricin loop (α-SRL) of rRNA.
Jia-Qi Lu, Zhen-Ning Zhu, Yong-Tang Zheng, Pang-Chui Shaw   +3 more
doaj   +1 more source

Non‐invasive and efficient diabetic retinal mitochondrial repair nanoplatform based on engineered endothelial mitochondrial‐derived vesicles with dynamic integrated stress response modulation

Interdisciplinary Medicine, Volume 4, Issue 2, March 2026.
Under hyperglycemic conditions, mitochondrial dysfunction in retinal endothelial cells triggers excessive reactive oxygen species/reactive nitrogen species production, barrier protein degradation, and endothelial barrier breakdown in diabetic retinopathy.
Siyu Gui, Jie Gao, Tianchang Tao, Peng Wang, Zhihao Huang, Yuyang She, Jiajie Li, Jingwan Su, Zhe Lu, Jianchao Qiao, Song Wang, Xiaodong Sun, Mohan Li   +12 more
wiley   +1 more source

T cell epitopes and its use as an immunotoxin warhead

, 2016
Fungal ribotoxins that block protein synthesis can be useful warheads in the context of a targeted immunotoxin. α-Sarcin is a small (17 kDa) fungal ribonuclease produced by Aspergillus giganteus that functions by catalytically cleaving a single ...
Kurt R. Gehlsen, Gehlsen, K.R., Kozub, D., Lacadena García-Gallo, Francisco Javier, Francis J. Carr, Matthew P. Baker, Javier Lacadena, Baker, M.P., Tim D. Jones, Jones, T.D., Fogg, M.H., Holgate, R.G., Carr, F.J., Arron R. Hearn, Dorota Kozub, Robert G.E. Holgate, Mark H. Fogg, Hearn, A.R.   +17 more
core   +1 more source