Results 71 to 80 of about 6,038 (211)

Pore-Forming Proteins from Cnidarians and Arachnids as Potential Biotechnological Tools

Toxins, 2019
Animal venoms are complex mixtures of highly specialized toxic molecules. Cnidarians and arachnids produce pore-forming proteins (PFPs) directed against the plasma membrane of their target cells.
Esperanza Rivera-de-Torre, Juan Palacios-Ortega, José G. Gavilanes, Álvaro Martínez-del-Pozo, Sara García-Linares   +4 more
doaj   +1 more source

Reduction of graft-versus-host reactivity after small bowel transplantation: ex vivo treatment of intestinal allografts with an anti-T cell immunotoxin

, 1992
SUMMARY A specific T lymphocyte immunotoxin was used to pre-treat small bowel grafts in an attempt to prevent graft-versus-host (GVH) reactivity and GVH disease in a rat transplant model.
B A PRICE, J W FABRE, C L INGHAM CLARK, R F M WOOD, P W CRANE, G J SMITH, P A LEAR   +6 more
core   +1 more source

Antiviral Immunotoxin Against Bovine herpesvirus-1: Targeted Inhibition of Viral Replication and Apoptosis of Infected Cell

Frontiers in Microbiology, 2018
Bovine herpesvirus 1 (BoHV-1) is a highly contagious viral pathogen which causes infectious bovine rhinotracheitis in cattle worldwide. Currently, there is no antiviral prophylactic treatment available capable of mitigating the disease impact and ...
Jian Xu, Jian Xu, Xiaoyang Li, Xiaoyang Li, Xiaoyang Li, Bo Jiang, Bo Jiang, Xiaoyu Feng, Jing Wu, Jing Wu, Jing Wu, Yunhong Cai, Yunhong Cai, Xixi Zhang, Xixi Zhang, Xiufen Huang, Xiufen Huang, Joshua E. Sealy, Munir Iqbal, Yongqing Li, Yongqing Li   +20 more
doaj   +1 more source

Exploring the Role of Acrylamide in Food Allergy via Dendritic Cell‐Dependent Th2 Immune Responses

Food Frontiers, Volume 7, Issue 1, January 2026.
Acrylamide may disrupt immune tolerance as a foodborne immunotoxicant, priming allergic inflammatory susceptibility through DC‐dependent Th2/Th17 polarization, TLR4/NF‐κB signaling amplification, and IL‐10 production suppression. ABSTRACT Acrylamide (AA), a prevalent food processing contaminant with recognized multi‐organ toxicity, has an unexplored ...
Xue Feng, Jiamin Chen, Zhencong Yang, Philippe Madjirebaye, Zhoujin Xu, Li Yan, Yuting Fan, Xiaoliang Shu, Xuli Wu   +8 more
wiley   +1 more source

A novel bispecific immunotoxin delivered by human bone marrow-derived mesenchymal stem cells to target blood vessels and vasculogenic mimicry of malignant gliomas

, 2015
Yonghong Zhang,1,2 Xinlin Sun,1 Min Huang,1 Yiquan Ke,1 Jihui Wang,1 Xiao Liu1 1National Key Clinic Specialty, Neurosurgery Institute of Guangdong Province, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of ...
Ke Y, Liu X, Zhang Y, Huang M, Sun X, Wang J   +5 more
core  

Engineering of Ribosome-inactivating Proteins for Improving Pharmacological Properties

Toxins, 2020
Ribosome-inactivating proteins (RIPs) are N-glycosidases, which depurinate a specific adenine residue in the conserved α-sarcin/ricin loop (α-SRL) of rRNA.
Jia-Qi Lu, Zhen-Ning Zhu, Yong-Tang Zheng, Pang-Chui Shaw   +3 more
doaj   +1 more source

Comprehensive Review on the Occurrence of Aflatoxin M1 in Milk, Prevalent Health Issues Associated With It, and Innovative Strategies for Mitigation of Aflatoxin M1 in Processed Milk

Food Safety and Health, Volume 4, Issue 1, Page 67-81, January 2026.
Aflatoxins, carcinogenic compounds in milk; reduction strategies such as thermal deactivation, UV light exposure, ionizing radiation, and solvent extraction. ABSTRACT Aflatoxins (AFs) are known to be cancer causing substances recognized within milk along with the milk goods.
Akshay Ramani, Tanmay Hazra, Anamika Das, Subhadip Manik, Ayon Tarafdar, Swarnima Dey, Umesh Singh   +6 more
wiley   +1 more source

T cell epitopes and its use as an immunotoxin warhead

, 2016
Fungal ribotoxins that block protein synthesis can be useful warheads in the context of a targeted immunotoxin. α-Sarcin is a small (17 kDa) fungal ribonuclease produced by Aspergillus giganteus that functions by catalytically cleaving a single ...
Kurt R. Gehlsen, Gehlsen, K.R., Kozub, D., Lacadena García-Gallo, Francisco Javier, Francis J. Carr, Matthew P. Baker, Javier Lacadena, Baker, M.P., Tim D. Jones, Jones, T.D., Fogg, M.H., Holgate, R.G., Carr, F.J., Arron R. Hearn, Dorota Kozub, Robert G.E. Holgate, Mark H. Fogg, Hearn, A.R.   +17 more
core   +1 more source

Rivers of Tears – Convergent, Multi‐Scale Approaches to Monitor and Optimize the Health of Our World's Inhabitants

Global Challenges, Volume 10, Issue 1, January 2026.
Probing and sustaining the health of Earth's ecosystems and their inhabitants requires convergent approaches at multiple length and time scales. Predictive computational and physical modeling, together with novel biotechnologies applied in unexpected ways, are paving the way for discoveries at the intersection of epidemiology and geospatial science ...
Eric J. Anderson, Vittorio Sansalone, Luke P. Lee, Rebecca Grainger, Sohie Lee, Albert L. Juhasz, Melissa L. Knothe Tate   +6 more
wiley   +1 more source

Bifenthrin Under Scrutiny: Revisiting Toxicological Evidence Amid Regulatory Gaps

Journal of Applied Toxicology, Volume 46, Issue 1, Page 61-77, January 2026.
ABSTRACT Despite growing health concerns, bifenthrin (BF) remains widely used for controlling agricultural and residential pests. However, different perspectives on its toxicological profile and regulatory framework warrant a revisit and update on BF regulation towards a robust risk‐safety assessment.
Caroline V. L. Moreira, John Ogbu I, Kadja L. C. Monteiro, Thiago M. de Aquino, Edeildo F. da Silva‐Júnior, Alberto S. S. Filho, Hamilton B. Napolitano, Christianah A. Elusiyan, Renê O. do Couto, Elson A. Costa, James O. Fajemiroye   +10 more
wiley   +1 more source