Insights into the mechanism of cell death induced by saporin delivered into cancer cells by an antibody fusion protein targeting the transferrin receptor 1 [PDF]
, 2012 We previously developed an antibody-avidin fusion protein (ch128.1Av) that targets the human transferrin receptor 1 (TfR1) and exhibits direct cytotoxicity against malignant B cells in an iron-dependent manner. ch128.1Av is also a delivery system and its
Casero, David +9 more
core +2 more sources
Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines
Advanced Science, Volume 13, Issue 10, 18 February 2026.Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira +18 more
wiley +1 more source
Immunotoxins Targeting B cell Malignancy—Progress and Problems With Immunogenicity
Biomedicines, 2018 Few immunotoxins or targeted toxins have become mainline cancer therapies. Still immunotoxins continue to be of major interest and subject of research and development as alternative therapies for drug resistant cancer. A major matter of concern continues
Daniel A. Vallera, Robert J. Kreitman
doaj +1 more source
Antimicrobial activity of nine extracts of sechium edule (Jacq) swartz [PDF]
, 2003 The antimicrobial properties of Sechium edule (Jacq) Swartz alcoholic extracts obtained according to the Farmacopea Argentina (6th edn) were tested against bacteria of clinical relevance as nosocomial pathogens.
Cudmani, Norma Mercedes +4 more
core +1 more source
The CNS Meninges and the Synovial Joint: Parallel Immunological Structures in Autoimmune Disease
BioEssays, Volume 48, Issue 2, February 2026.The meninges and synovium share multiple functional and structural characteristics and act as specialized immunological barriers. In MS and RA, both can host tertiary lymphoid organs (TLOs) and CD4+ Tph cells. We highlight how these features sustain compartmentalized inflammation and explore a possible role for EBV in their formation and persistence ...
Mohamed Reda Fazazi, Manu Rangachari
wiley +1 more source
A retinoraphe projection regulates serotonergic activity and looming-evoked defensive behaviour [PDF]
, 2017 published_or_final_versio
Han, Y +15 more
core +2 more sources
CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.A novel mouse model of mesial temporal lobe epilepsy (MTLE) with hippocampal sclerosis (HS) by unilateral, partial ablation of hippocampal GABAergic neurons is established. The model recapitulates key features of the human condition, including spontaneous recurrent seizures, HS‐like pathology, and associated cognitive deficits.
Ting Tang +10 more
wiley +1 more source
Design of a Humanized Immunotoxin Based on Pertuzumab-Derived scFv and Shiga-Like Toxin 2 Subunit A Against Breast Cancer: An In Silico Study [PDF]
Journal of Mazandaran University of Medical SciencesBackground and purpose: Breast cancer is the second cause of mortality among women. HER2, a member of the epidermal growth factor receptor family, is overexpressed in approximately 25% of breast cancer cases.
Zeinab Ghesmati +10 more
doaj
Toxins, 2017 Cancer immunotherapy is becoming a routine treatment modality in the oncology clinic, in spite of the fact that it is a relatively nascent field. The challenge in developing effective immunotherapeutics is the identification of target molecules that ...
Trevor R. Baybutt +2 more
doaj +1 more source
Selective inhibition of dopamine-beta-hydroxylase enhances dopamine release from noradrenergic terminals in the medial prefrontal cortex [PDF]
, 2015 Introduction: Disulfiram has been claimed to be useful in cocaine addiction therapy, its efficacy being attributed to dopamine-beta-hydroxylase (DBH) inhibition.
Devoto, Paola +4 more
core +1 more source