Results 51 to 60 of about 6,038 (211)

Heterogeneity of Cancer‐Associated Fibroblasts and Precision Targeting Strategies for Cancer Therapy

Thoracic Cancer, Volume 17, Issue 11, June 2026.
CAFs orchestrate tumor immunosuppression through spatially organized ECM remodeling, cytokine signaling, and metabolic reprogramming. Targeting CAFs requires a shift from marker‐based depletion to functional state and niche‐specific intervention. ABSTRACT Immune checkpoint blockade (ICB) has transformed cancer therapy, but its effect is often limited ...
Yijie Wang, Guangyao Zhou, Pengpeng Zhang, Zhenfa Zhang, Lianmin Zhang   +4 more
wiley   +1 more source

Plant‐Produced Viral Nanoparticles Decorated with Nanobodies Against HER2 Improve Retention and Recruitment of Immune Cells in Solid Tumors

Advanced Healthcare Materials, Volume 15, Issue 18, 15 May 2026.
Potato virus X is a filamentous RNA plant virus that can be engineered into a molecular tool for cancer therapy. We produced genetically‐encoded virus‐derived nanoparticles decorated with nanobodies targeting cancer cell receptors, epidermal growth factor receptor (EGFR) and human epidermal growth factor 2 (HER2).
Enrique Lozano‐Sanchez, Miguel A. Moreno‐Gonzalez, Fernando Merwaiss, Nicole F. Steinmetz, José‐Antonio Daròs   +4 more
wiley   +1 more source

Monolith affinity chromatography for the rapid quantification of a single-chain variable fragment immunotoxin

, 2018
We developed a novel analytical method for concentration determination of tandem single-chain antibody diphtheria toxin (immunotoxin). The method is based on polymethacrylate monoliths with Protein L ligands as the binding moiety.
Sommer, Ralf, Klaus Hofstädter, Satzer, Peter, Hofstädter, Klaus, Ralf Sommer, Romana Zehetner, Agnes Rodler, Klade, Christoph, Christoph Klade, Jungbauer, Alois, Paulsson, Johanna, Zehetner, Romana, Johanna Paulsson, Rodler, Agnes, Peter Satzer, Alois Jungbauer   +15 more
core   +1 more source

Correspondence of Basal Forebrain Resting‐State Functional Connectivity and Cerebral Glucose Metabolism Alterations With Neurotransmitter Maps in Alzheimer's Disease

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
Altered functional connectivity of basal forebrain subregions (Ch1‐3, Ch4) and widespread cerebral hypometabolism were identified in Alzheimer's disease using simultaneous PET/MRI. Spatial correspondence with normative neurotransmitter receptor and transporter maps suggested that serotonergic and dopaminergic systems may contribute to AD‐related ...
Yujie He, Hanxiao Xue, Sheng Bi, Yan Wang, Xiaocao Liu, Yixia Li, Zhigeng Chen, Dongdong Rong, Bixiao Cui, Jie Ma, Shaozhen Yan, Jie Lu   +11 more
wiley   +1 more source

A Single-Domain Antibody-Based Anti-PSMA Recombinant Immunotoxin Exhibits Specificity and Efficacy for Prostate Cancer Therapy

, 2021
Prostate cancer (PCa) is the second most common cancer in men, causing more than 300,000 deaths every year worldwide. Due to their superior cell-killing ability and the relative simplicity of their preparation, immunotoxin molecules have great potential ...
Wenjing Li, Zhangyong Hong, Yue Nan, Li Cao, Shixiong Li, Qiyu Li, Yutong Xing, Keyuan Xu   +7 more
core   +1 more source

Species-Dependent Functionality of the Human Cytolytic Fusion Proteins Granzyme B-H22(scFv) and H22(scFv)-Angiogenin in Macrophages

Antibodies, 2013
Human cytolytic fusion proteins (hCFPs) are comprised of a specific cell-surface-binding moiety and an effector molecule of human origin. In contrast to common immunotoxins, including bacterial or plant toxins, they are considered not to be immunogenic ...
Theo Thepen, Stefan Barth, Rainer Fischer, Michael Huhn, Radoslav Mladenov, Eric Aslanian, Dmitrij Hristodorov, Sonja Schiffer   +7 more
doaj   +1 more source

IL-13Rα2 Status Predicts GB-13 (IL13.E13K-PE4E) Efficacy in High-Grade Glioma

Pharmaceutics, 2022
High-grade gliomas (HGG) are devastating diseases in children and adults. In the pediatric population, diffuse midline gliomas (DMG) harboring H3K27 alterations are the most aggressive primary malignant brain tumors. With no effective therapies available,
Julian S. Rechberger, Kendra A. Porath, Liang Zhang, Cody L. Nesvick, Randy S. Schrecengost, Jann N. Sarkaria, David J. Daniels   +6 more
doaj   +1 more source

Mechanistic Insights Into Photocatalytic Materials for Toxic Pollutants: Environmental Remediation of Personal Care Products

Asia-Pacific Journal of Chemical Engineering, Volume 21, Issue 2, March/April 2026.
ABSTRACT Photocatalytic materials have emerged as promising solutions for environmental applications due to their ability to degrade organic pollutants under sunlight or artificial light. In this review, recent progress on the photocatalytic materials used for the degradation of pharmaceutical personal care products (PPCPs) in environmental ...
Urvashi Sen, Gunjan Chauhan, Surbhi Soni, Monika Vats, Anand Kumar, Indra Bahadur   +5 more
wiley   +1 more source

Non‐invasive and efficient diabetic retinal mitochondrial repair nanoplatform based on engineered endothelial mitochondrial‐derived vesicles with dynamic integrated stress response modulation

Interdisciplinary Medicine, Volume 4, Issue 2, March 2026.
Under hyperglycemic conditions, mitochondrial dysfunction in retinal endothelial cells triggers excessive reactive oxygen species/reactive nitrogen species production, barrier protein degradation, and endothelial barrier breakdown in diabetic retinopathy.
Siyu Gui, Jie Gao, Tianchang Tao, Peng Wang, Zhihao Huang, Yuyang She, Jiajie Li, Jingwan Su, Zhe Lu, Jianchao Qiao, Song Wang, Xiaodong Sun, Mohan Li   +12 more
wiley   +1 more source

In vivo administration of UCHL1 immunotoxin or mAb.

, 2013
Groups of three aviremic SHIV-infected macaques each received escalating doses of UCHL1-ricin A chain immunotoxin (panels A and C) or UCHL1 mAb (panels B and D). A.
Michael Valentine (454173), Grace A. Maresh (293454), Shiu-Lok Hu (156823), Anthony Cristillo (454176), Maria Cecilia Huaman (454175), Kejing Song (406730), Heather Mack (454174), On Ho (178497), Seth H. Pincus (293455), Hye Kyung Chung (454177), Patricia Polacino (178498)   +10 more
core   +1 more source