Results 31 to 40 of about 9,896 (218)
Treatment with immunotoxin [PDF]
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2001 T–cell depletion prior to or beginning at the time of transplantation has been shown to be a valuable adjunct to the induction of immunological unresponsiveness. Both total lymphoid irradiation and anti–lymphocyte globulin have been used for this purpose in experimental models of transplantation as well as in human organ transplant recipients. However,
openaire +2 more sources
Mab-Zap: A Tool for Evaluating Antibody Efficacy for Use in an Immunotoxin
BioTechniques, 2000 Immunotoxins, consisting of antibodies coupled to toxins, are extremely useful tools in the elimination of specific cell populations in vitro and in vivo for research and therapeutic applications.
Matthew D. Kohls, Douglas A. Lappi
doaj +1 more source
Enhancing the efficacy of cytotoxic agents for cancer therapy using photochemical internalisation. [PDF]
, 2015 Photochemical internalisation (PCI) is a technique for improving cellular delivery of certain bioactive agents which are prone to sequestration within endolysosomes.
Adigbli +69 more
core +1 more source
Design and evaluation of a peptide‐based immunotoxin for breast cancer therapeutics
FEBS Open Bio, 2015 Immunotoxins are chimeric proteins comprising a specific cellular targeting domain linked to a cytotoxic factor. Here we describe the design and use of a novel, peptide‐based immunotoxin that can initiate selective cytotoxicity on ErbB2‐positive cells ...
Kelsey J. Weigel +6 more
doaj +1 more source
In Vitro Evaluation of Vegf-Pseudomonas Exotoxin: A Conjugated on Tumor Cells
Advanced Biomedical Research, 2017 Background: Angiogenesis which occurs mandatory in solid tumors, is a critical step in malignancy progression. Vascular endothelial growth factor (VEGF) is mainly responsible for angiogenesis process and facilitates the formation of new vessels ...
Jahangir Langari +10 more
doaj +1 more source
Engineering of Ribosome-inactivating Proteins for Improving Pharmacological Properties
Toxins, 2020 Ribosome-inactivating proteins (RIPs) are N-glycosidases, which depurinate a specific adenine residue in the conserved α-sarcin/ricin loop (α-SRL) of rRNA.
Jia-Qi Lu +3 more
doaj +1 more source
Immunotoxins and Anticancer Drug Conjugate Assemblies: The Role of the Linkage between Components [PDF]
, 2011 Immunotoxins and antibody-drug conjugates are protein-based drugs combining a target-specific binding domain with a cytotoxic domain. Such compounds are potentially therapeutic against diseases including cancer, and several clinical trials have shown ...
Franco Dosio, Luigi Cattel, Paola Brusa
core +3 more sources
Biotherapy, 1991 Immunotoxins (ITs) are chimeric molecules constructed by covalently conjugating monoclonal antibodies (MoAbs) to plant or bacterial toxins (e.g. ricin or pseudomonas exotoxin). The antibody moiety allows specific targeting of ITs to tumor-associated antigens, while the toxin moiety is responsible for cell killing by irreversible inactivation of protein
openaire +4 more sources
Dosing optimization of CCR4 immunotoxin for improved depletion of CCR4+ Treg in nonhuman primates
Molecular Oncology, 2018 Recently, we have developed a diphtheria toxin‐based recombinant anti‐human CCR4 immunotoxin for targeting CCR4+ tumors and Tregs. In this study, we further optimized the dosing schedule for improved CCR4+ Treg depletion.
Zhaohui Wang +10 more
doaj +1 more source
The emerging role of anti-CD25 directed therapies as both immune modulators and targeted agents in cancer [PDF]
, 2017 CD25 (also termed IL2RA) forms one component of the high‐affinity heterotrimeric interleukin 2 (IL2) receptor on activated T cells. Its affinity for IL2 and cellular function are tightly regulated and vary in different cell types.
Flynn, MJ, Hartley, JA
core +1 more source