Results 31 to 40 of about 6,038 (211)
Mab-Zap: A Tool for Evaluating Antibody Efficacy for Use in an Immunotoxin
BioTechniques, 2000 Immunotoxins, consisting of antibodies coupled to toxins, are extremely useful tools in the elimination of specific cell populations in vitro and in vivo for research and therapeutic applications.
Matthew D. Kohls, Douglas A. Lappi
doaj +1 more source
Immunotoxins: The Role of the Toxin [PDF]
Toxins, 2013 Immunotoxins are antibody-toxin bifunctional molecules that rely on intracellular toxin action to kill target cells. Target specificity is determined via the binding attributes of the chosen antibody. Mostly, but not exclusively, immunotoxins are purpose-built to kill cancer cells as part of novel treatment approaches.
David FitzGerald, Antonella Antignani
openaire +3 more sources
CD30 as a Target Molecule in the Diagnosis and Therapy of Lymphomas. [PDF]
Am J HematolABSTRACT The tumor necrosis factor (TNF)‐receptor superfamily 8 receptor CD30 molecule is expressed in all tumor cells of Hodgkin lymphoma and anaplastic large cell lymphoma but is only weakly expressed in a small subset of large lymphoid cells in normal peripheral lymphoid tissues.
Stein H, Falini B.
europepmc +2 more sources
In Vitro Evaluation of Vegf-Pseudomonas Exotoxin: A Conjugated on Tumor Cells
Advanced Biomedical Research, 2017 Background: Angiogenesis which occurs mandatory in solid tumors, is a critical step in malignancy progression. Vascular endothelial growth factor (VEGF) is mainly responsible for angiogenesis process and facilitates the formation of new vessels ...
Jahangir Langari +10 more
doaj +1 more source
Toxins, 2020 Toxins, while harmful and potentially lethal, have been engineered to develop potent therapeutics including cytotoxins and immunotoxins (ITs), which are modalities with highly selective targeting capabilities.
Shusei Hamamichi +2 more
doaj +1 more source
Biotherapy, 1991 Immunotoxins (ITs) are chimeric molecules constructed by covalently conjugating monoclonal antibodies (MoAbs) to plant or bacterial toxins (e.g. ricin or pseudomonas exotoxin). The antibody moiety allows specific targeting of ITs to tumor-associated antigens, while the toxin moiety is responsible for cell killing by irreversible inactivation of protein
openaire +4 more sources
Targeting Receptors on Cancer Cells with Protein Toxins
Biomolecules, 2020 Cancer cells frequently upregulate surface receptors that promote growth and survival. These receptors constitute valid targets for intervention. One strategy involves the delivery of toxic payloads with the goal of killing those cancer cells with high ...
Antonella Antignani +5 more
doaj +1 more source
Frontiers in Oncology, 2021 Cancer is one of the prominent causes of death worldwide. Despite the existence of various modalities for cancer treatment, many types of cancer remain uncured or develop resistance to therapeutic strategies.
Seyed Mehdi Havaei +2 more
doaj +1 more source
Prenatal Diagnosis, EarlyView.ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde +4 more
wiley +1 more source
Kinetic events involved in immunotoxin-antigen binding and intracellular trafficking.
, 2014 Each yellow arrow indicates a kinetic step of the model. The tumor cell sheds the surface antigen and the surface complexed antigen at a certain rate. The immunotoxin molecule exiting from the capillary diffuses in the extra-cellular space and binds to ...
Robert J. Kreitman (649284) +3 more
core +1 more source