Results 21 to 30 of about 6,607 (210)
Treatment with immunotoxin [PDF]
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2001 T–cell depletion prior to or beginning at the time of transplantation has been shown to be a valuable adjunct to the induction of immunological unresponsiveness. Both total lymphoid irradiation and anti–lymphocyte globulin have been used for this purpose in experimental models of transplantation as well as in human organ transplant
openaire +2 more sources
Antiviral Activity of Ribosome-Inactivating Proteins
Toxins, 2021 Ribosome-inactivating proteins (RIPs) are rRNA N-glycosylases from plants (EC 3.2.2.22) that inactivate ribosomes thus inhibiting protein synthesis. The antiviral properties of RIPs have been investigated for more than four decades.
Lucía Citores +2 more
doaj +1 more source
Blood, 2014 AbstractUnconjugated monoclonal antibodies that target hematopoietic differentiation antigens have been developed to treat hematologic malignancies. Although some of these have activity against chronic lymphocytic leukemia and hairy cell leukemia, in general, monoclonal antibodies have limited efficacy as single agents in the treatment of leukemia.
Alan S, Wayne +3 more
openaire +3 more sources
, 2023 Crotamine, one of the major toxins present in the venom of the South American rattlesnake Crotalus durissus terrificus, exhibits potent cytotoxic properties and has been suggested for cancer therapy applications. However, its selectivity for cancer cells
Minh Quan Nguyen +8 more
core +1 more source
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2021 Introduction: Overexpression of the EGFR is associated with carcinogenesis, and it is observed in more than 70% of head and neck cancers. The expression of an immunotoxin against EGFR designed as an alternative to full antibody led to the production of ...
Bahman Akbari
doaj
, 2021 Immunotoxins are hybrid molecules composed of a monoclonal antibody chemically linked to a biologic toxin. The antibody portion of the molecule directs it to a specific antigenic determinant on a target cell; the molecule is then internalized, and a ...
Blessy M.R*, Subash Chandran M.P, Prasobh G.R, Remya S.B, Aparna P, Rohini L M, Varsha V R, Archana L R
core +1 more source
GUCY2C lysosomotropic endocytosis delivers immunotoxin therapy to metastatic colorectal cancer. [PDF]
, 2014 The emergence of targeted cancer therapy has been limited by the paucity of determinants which are tumor-specific and generally associated with disease, and have cell dynamics which effectively deploy cytotoxic payloads.
Michael S. Magee +11 more
core +2 more sources
Depletion of Alloreactive T-Cells by Anti-CD137-Saporin Immunotoxin
Cell Transplantation, 2015 Depletion of alloreactive T-lymphocytes from allogeneic bone marrow tansplants may prevent graft-versus-host disease (GVHD) without impairing donor cell engraftment, immunity, and the graft-versus-leukemia (GVL) effect.
Sang C. Lee +8 more
doaj +1 more source
Bacteria-derived chimeric toxins as potential anticancer agents
Frontiers in Oncology, 2022 Cancer is one of the major causes of death globally, requiring everlasting efforts to develop novel, specific, effective, and safe treatment strategies.
Saeed Khoshnood +7 more
doaj +1 more source
Mab-Zap: A Tool for Evaluating Antibody Efficacy for Use in an Immunotoxin
BioTechniques, 2000 Immunotoxins, consisting of antibodies coupled to toxins, are extremely useful tools in the elimination of specific cell populations in vitro and in vivo for research and therapeutic applications.
Matthew D. Kohls, Douglas A. Lappi
doaj +1 more source