Construction, Expression, and Characterization of a Recombinant Immunotoxin Targeting EpCAM [PDF]
Mediators of Inflammation, 2015 Epithelial cell adhesion molecule (EpCAM) is a type I transmembrane glycoprotein overexpressed in human epithelioma but with relatively low expression in normal epithelial tissues.
Minghua Lv +9 more
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Combination treatments with the PKC inhibitor, enzastaurin, enhance the cytotoxicity of the anti-mesothelin immunotoxin, SS1P. [PDF]
PLoS ONE, 2013 Activated protein kinase C (PKC) contributes to tumor survival and proliferation, provoking the development of inhibitory agents as potential cancer therapeutics.
Abid R Mattoo +2 more
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BioTechniques, 2003 A major problem encountered in the large-scale purification of the bivalent anti-T cell immunotoxin, A-dmDT390-bisFv(G4S), from Pichia pastoris supernatants was the presence of host glycoproteins exhibiting similar charge, size, and hydrophobicity ...
Jung Hee Woo, David M. Neville
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Design and evaluation of a peptide‐based immunotoxin for breast cancer therapeutics
FEBS Open Bio, 2015 Immunotoxins are chimeric proteins comprising a specific cellular targeting domain linked to a cytotoxic factor. Here we describe the design and use of a novel, peptide‐based immunotoxin that can initiate selective cytotoxicity on ErbB2‐positive cells ...
Kelsey J. Weigel +6 more
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Enhanced cytotoxicity of a Pseudomonas Exotoxin A based immunotoxin against prostate cancer by addition of the endosomal escape enhancer SO1861 [PDF]
Frontiers in Pharmacology, 2023 Immunotoxins consist of an antibody or antibody fragment that binds to a specific cell surface structure and a cytotoxic domain that kills the cell after cytosolic uptake. Pseudomonas Exotoxin A (PE) based immunotoxins directed against a variety of tumor
Anie P. Masilamani +25 more
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Dosing optimization of CCR4 immunotoxin for improved depletion of CCR4+ Treg in nonhuman primates
Molecular Oncology, 2018 Recently, we have developed a diphtheria toxin‐based recombinant anti‐human CCR4 immunotoxin for targeting CCR4+ tumors and Tregs. In this study, we further optimized the dosing schedule for improved CCR4+ Treg depletion.
Zhaohui Wang +10 more
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Immunotoxin-Induced Ablation of the Intrinsically Photosensitive Retinal Ganglion Cells in Rhesus Monkeys [PDF]
Frontiers in Neurology, 2018 Purpose: Intrinsically photosensitive retinal ganglion cells (ipRGCs) contain the photopigment melanopsin, and are primarily involved in non-image forming functions, such as the pupillary light reflex and circadian rhythm entrainment.
Lisa A. Ostrin +8 more
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A Novel Immunotoxin Based on BmK AGAP Toxin for HER2-Positive Breast Cancer: An In Silico Study [PDF]
Journal of Mazandaran University of Medical SciencesBackground and purpose: Breast cancer remains one of the leading causes of cancer-related deaths among women worldwide. The HER2 protein, an epidermal growth factor receptor, is overexpressed in approximately 25% of breast cancer cases, making it a key ...
Sadaf Azdoo +12 more
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Cloning and Expression of Recombinant Immunotoxin using Diphtheria Toxin and Granulocyte Colony Stimulating Factor (G-CSF) [PDF]
Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2016 Background: Immunotoxin (IT) is a directed toxin containing two distinct sections (immune and toxin parts) covalently bond using specific chemical or peptide linkers.
Fatemeh Donyapoor +2 more
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Targeted delivery of immunotoxin by antibody to ganglioside GD3: a novel drug delivery route for tumor cells. [PDF]
PLoS ONE, 2013 Gangliosides are sialic acid-containing glycolipids expressed on plasma membranes from nearly all vertebrate cells. The expression of ganglioside GD3, which plays essential roles in normal brain development, decreases in adults but is up regulated in ...
Vanina Torres Demichelis +4 more
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