Results 41 to 50 of about 6,607 (210)

In Utero HSC Transplantation for Sickle Cell Disease: A Potential Therapeutic Approach That Overcomes Complications of Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Kinetic events involved in immunotoxin-antigen binding and intracellular trafficking.

, 2014
Each yellow arrow indicates a kinetic step of the model. The tumor cell sheds the surface antigen and the surface complexed antigen at a certain rate. The immunotoxin molecule exiting from the capillary diffuses in the extra-cellular space and binds to ...
Robert J. Kreitman (649284), Youngshang Pak (649283), Ira Pastan (303807), Byungkook Lee (35660)   +3 more
core   +1 more source

Production of a Granulysin-Based, Tn-Targeted Cytolytic Immunotoxin Using Pulsed Electric Field Technology [PDF]

, 2020
Granulysin is a protein present in the granules of human cytotoxic T lymphocytes (CTL) and natural killer (NK) cells, with cytolytic activity against microbes and tumors.
Hurtado-Guerrero, Ramón, Guerrero-Ochoa, Patricia, Javier Raso, Patricia Guerrero-Ochoa, Alberto Anel, Macías-León, Javier, Ramón Hurtado-Guerrero, Ibáñez-Pérez, Raquel, Diederich Aguilar-Machado, Anel, Alberto, Javier Macías-León, Aguilar-Machado, Diederich, Raquel Ibáñez-Pérez, Raso, Javier, Aguilar-Machado, D.   +14 more
core   +1 more source

Development of a new minimally invasive phototherapy for lung cancer using antibody–toxin conjugate

Thoracic Cancer, 2023
Background Photodynamic therapy (PDT) is a cancer‐targeted treatment that uses a photosensitizer (PS) and laser irradiation. The effectiveness of current PDT using red light for advanced cancers is limited, because red light can only reach depths within ...
Takumi Sonokawa, Naoko Obi, Jitsuo Usuda, Yukio Sudo, Takao Hamakubo   +4 more
doaj   +1 more source

Development of Novel CD47-Specific ADCs Possessing High Potency Against Non-Small Cell Lung Cancer in vitro and in vivo

Frontiers in Oncology, 2022
Targeted therapies hold promise for efficiently and accurately delivering cytotoxic drugs directly to tumor tissue to exert anticancer effects. CD47 is a membrane protein expressed in a variety of malignant tumors and hematopoietic cells, which plays a ...
Zu-Chian Chiang, Zu-Chian Chiang, Zu-Chian Chiang, Shubin Fang, Yang-kun Shen, Dongya Cui, Huanjiao Weng, Dawei Wang, Yuxiang Zhao, Jizhen Lin, Jizhen Lin, Qi Chen   +11 more
doaj   +1 more source

Genome Manipulation in Microalgae: A Systematic Map on Improved Traits, Strains, and Their Commercial Applications

Reviews in Aquaculture, Volume 18, Issue 4, September 2026.
ABSTRACT Microalgae are promising platforms for producing diverse biocompounds relevant to multiple commercial sectors, and the use of genomic technologies in microalgae is rapidly expanding. To examine the research trends, we conducted a bibliographic analysis (systematic map) of this rapidly developing field. Our study presents a descriptive overview
Irene Gallego, Michael Meissle, Jörg Romeis   +2 more
wiley   +1 more source

Different sensitivity of CD30+ cell lines to Ber-H2/saporin-S6 immunotoxin

, 1998
The in vitro sensitivity of cells to a Ber-H2(anti-CD30)/saporin-S6 immunotoxin has been investigated. The CD30+ cell lines, K562, L428 and L540, were used to study cell binding, uptake and degradation of the immunotoxin.
Olivieri F., Polito L., Bolognesi A., Stirpe F., Battelli M. G.   +4 more
core   +1 more source

Actinomycin Derivatives: Structural Diversification and Biological Activities

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Actinomycins are chromopeptide antibiotics exhibiting remarkable structural diversity and broad bioactivity. This review traces their development from naturally occurring D‐, X‐, A‐, G‐, Y‐, and Z‐type analogs to precursor‐directed, synthetic, and semisynthetic derivatives.
Özge Can, Erdal Bedir
wiley   +1 more source

Regulation of PD‐1PD‐L1 Immune Checkpoints by Gut Microbiota Metabolites and Their Clinical Translational Research: A Review

Immunity, Inflammation and Disease, Volume 14, Issue 7, July 2026.
ABSTRACT Background Immune checkpoint inhibitors (ICIs) targeting the PD‐1/PD‐L1 pathway have revolutionized cancer immunotherapy, yet their clinical benefit is constrained by variable response rates and immune‐related adverse events. Aims This review systematically analyzes the molecular mechanisms by which key gut microbiota‐derived metabolites ...
Xuanyou Fang, Shuai Yuan, Weijian Mai
wiley   +1 more source

Construction of a recombinant immunotoxin [PDF]

, 1995
University of Technology, Sydney. Faculty of Science.In recent years a number of therapeutically useful immunotoxins have been produced using recombinant gene technology.

core   +1 more source