Results 61 to 70 of about 6,038 (211)

Dysregulated Expression of Glycolipids in Tumor Cells: From Negative Modulator of Anti-Tumor Immunity to Promising Targets for Developing Therapeutic Agents

Frontiers in Oncology, 2016
Glycolipids are complex molecules consisting of a ceramide lipid moiety linked to a glycan chain of variable length and structure. Among these are found the gangliosides, which are sialylated glycolipids ubiquitously distributed on the outer layer of ...
Jose Luis Daniotti, Ricardo Dante Lardone, Aldo Alejandro Vilcaes   +2 more
doaj   +1 more source

Engineered Elastin‐Like Polypeptides: Intelligent Self‐Assembling Platforms for Biomedical Application

Small Structures, Volume 7, Issue 3, March 2026.
Armed with unique structural and functional properties, elastin‐like polypeptides attract their attentions as programmable materials in biomedical applications, including fusion tags for protein and nucleic acid purification; nanocarriers for protein, chemotherapeutics, and imaging agent delivery; hydrogels for tissue regeneration, 3D model ...
Yang Yuan, Chen Zeng, Zichun Chen, Zhuoga Ciren, Qinran Yu, Chuanbo Wang, Hui Mao, Gang Li, Weizhi Chen, Xiqun Jiang   +9 more
wiley   +1 more source

Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines

Advanced Science, Volume 13, Issue 10, 18 February 2026.
Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira, David Agorku, Andre Rosa, Julia Roosz, Lena Christ, Nicole Anderle, Ajinkya Kulkarni, Abir Hussein, Sana S. Sayedipour, Omar F. Luna, Tobias Legler, Philipp Ströbel, Fernando Albericio, Luis Cruz, Phillipp Beckhove, Peter Loskill, Frauke Alves, M. Andrea Markus, Fernanda Ramos‐Gomes   +18 more
wiley   +1 more source

Design of a Humanized Immunotoxin Based on Pertuzumab-Derived scFv and Shiga-Like Toxin 2 Subunit A Against Breast Cancer: An In Silico Study [PDF]

Journal of Mazandaran University of Medical Sciences
Background and purpose: Breast cancer is the second cause of mortality among women. HER2, a member of the epidermal growth factor receptor family, is overexpressed in approximately 25% of breast cancer cases.
Zeinab Ghesmati, Khadijeh Ahmadi, Navid Nezafat, Farzaneh Vahedi, Mortaza Taheri-Anganeh, Seyyed Hossein Khatami, Hasan Ghasemi, Rahmatollah Soltani, Vahid Zarezade, Ahmad Movahedpour, Ahmad Movahedpour   +10 more
doaj  

Toxins VapC and PasB from Prokaryotic TA Modules Remain Active in Mammalian Cancer Cells

Toxins, 2014
Among the great number of addictive modules which have been discovered, only a few have been characterized. However, research concerning the adoption of toxins from these systems shows their great potential as a tool for molecular biology and medicine.
Łukasz Wieteska, Aleksander Skulimowski, Magdalena Cybula, Janusz Szemraj   +3 more
doaj   +1 more source

The CNS Meninges and the Synovial Joint: Parallel Immunological Structures in Autoimmune Disease

BioEssays, Volume 48, Issue 2, February 2026.
The meninges and synovium share multiple functional and structural characteristics and act as specialized immunological barriers. In MS and RA, both can host tertiary lymphoid organs (TLOs) and CD4+ Tph cells. We highlight how these features sustain compartmentalized inflammation and explore a possible role for EBV in their formation and persistence ...
Mohamed Reda Fazazi, Manu Rangachari
wiley   +1 more source

Domain II of Pseudomonas Exotoxin Is Critical for Efficacy of Bolus Doses in a Xenograft Model of Acute Lymphoblastic Leukemia

Toxins, 2018
Moxetumomab pasudotox is a fusion protein of a CD22-targeting antibody and Pseudomonas exotoxin. Minutes of exposure to Moxetumomab achieves similar cell killing than hours of exposure to a novel deimmunized variant against some acute lymphoblastic ...
Fabian Müller, Tyler Cunningham, Richard Beers, Tapan K. Bera, Alan S. Wayne, Ira Pastan   +5 more
doaj   +1 more source

Immunotoxin-mediated depletion of Gag-specific CD8+ T cells undermines natural control of SIV. [PDF]

JCI Insight
Antibody-mediated depletion studies have demonstrated that CD8+ T cells are required for effective immune control of SIV. However, this approach is potentially confounded by several factors, including reactive CD4+ T cell proliferation, and provides no ...
Simpson J, Starke CE, Ortiz AM, Ransier A, Darko S, Llewellyn-Lacey S, Fennessey CM, Keele BF, Douek DC, Price DA, Brenchley JM.   +10 more
europepmc   +3 more sources

Ablation of Unilateral Hippocampal GABAergic Neurons: A Novel Mouse Model of Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
A novel mouse model of mesial temporal lobe epilepsy (MTLE) with hippocampal sclerosis (HS) by unilateral, partial ablation of hippocampal GABAergic neurons is established. The model recapitulates key features of the human condition, including spontaneous recurrent seizures, HS‐like pathology, and associated cognitive deficits.
Ting Tang, Jinkun Xu, Bin Fu, Chao Geng, Yuhao Li, Yuying Qi, Changkai Hou, Junping He, Yihe Wang, Yumin Luo, Guoguang Zhao   +10 more
wiley   +1 more source

GUCY2C lysosomotropic endocytosis delivers immunotoxin therapy to metastatic colorectal cancer.

, 2014
The emergence of targeted cancer therapy has been limited by the paucity of determinants which are tumor-specific and generally associated with disease, and have cell dynamics which effectively deploy cytotoxic payloads.
Michael S. Magee, Magee, Michael Sullivan, Lisa D. Berman-Booty, Scott A. Waldman, Merlino, Dante, Marszalowicz, Glen P, Snook, Adam E, Waldman, Scott A, Dante Merlino, Berman-Booty, Lisa D, Glen P. Marszalowicz, Adam E. Snook   +11 more
core   +2 more sources