Results 61 to 70 of about 6,607 (210)

Monolith affinity chromatography for the rapid quantification of a single-chain variable fragment immunotoxin

, 2018
We developed a novel analytical method for concentration determination of tandem single-chain antibody diphtheria toxin (immunotoxin). The method is based on polymethacrylate monoliths with Protein L ligands as the binding moiety.
Sommer, Ralf, Klaus Hofstädter, Satzer, Peter, Hofstädter, Klaus, Ralf Sommer, Romana Zehetner, Agnes Rodler, Klade, Christoph, Christoph Klade, Jungbauer, Alois, Paulsson, Johanna, Zehetner, Romana, Johanna Paulsson, Rodler, Agnes, Peter Satzer, Alois Jungbauer   +15 more
core   +1 more source

Edulitin 2, a Ribotoxin‐Like Protein From Boletus edulis That Triggers Apoptosis in Colon Cancer Cells While Preserving the Integrity of the Intestinal Microbiota

eFood, Volume 7, Issue 3, June 2026.
Edulitin 2 is a ribotoxin‐like protein exhibiting a potent antiproliferative activity towards Caco‐2 and HT29 cells by programmed cell death. However, edulitin 2 does not affect gut microbiota growth, despite damaging fungal ribosomes. ABSTRACT Porcini (Boletus edulis Bull.) are a reservoir of pharmacological biomolecules with health‐promoting ...
Massimo Bortolotti, Sara Ragucci, Federica Falà, Anella Saggese, Francesco Biscotti, Ylenia De Luca, Nicola Landi, Paolo V. Pedone, Andrea Bolognesi, Ezio Ricca, Letizia Polito, Antimo Di Maro   +11 more
wiley   +1 more source

In vivo administration of UCHL1 immunotoxin or mAb.

, 2013
Groups of three aviremic SHIV-infected macaques each received escalating doses of UCHL1-ricin A chain immunotoxin (panels A and C) or UCHL1 mAb (panels B and D). A.
Michael Valentine (454173), Grace A. Maresh (293454), Shiu-Lok Hu (156823), Anthony Cristillo (454176), Maria Cecilia Huaman (454175), Kejing Song (406730), Heather Mack (454174), On Ho (178497), Seth H. Pincus (293455), Hye Kyung Chung (454177), Patricia Polacino (178498)   +10 more
core   +1 more source

Design of a Humanized Immunotoxin Based on Pertuzumab-Derived scFv and Shiga-Like Toxin 2 Subunit A Against Breast Cancer: An In Silico Study [PDF]

Journal of Mazandaran University of Medical Sciences
Background and purpose: Breast cancer is the second cause of mortality among women. HER2, a member of the epidermal growth factor receptor family, is overexpressed in approximately 25% of breast cancer cases.
Zeinab Ghesmati, Khadijeh Ahmadi, Navid Nezafat, Farzaneh Vahedi, Mortaza Taheri-Anganeh, Seyyed Hossein Khatami, Hasan Ghasemi, Rahmatollah Soltani, Vahid Zarezade, Ahmad Movahedpour, Ahmad Movahedpour   +10 more
doaj  

Toxins VapC and PasB from Prokaryotic TA Modules Remain Active in Mammalian Cancer Cells

Toxins, 2014
Among the great number of addictive modules which have been discovered, only a few have been characterized. However, research concerning the adoption of toxins from these systems shows their great potential as a tool for molecular biology and medicine.
Łukasz Wieteska, Aleksander Skulimowski, Magdalena Cybula, Janusz Szemraj   +3 more
doaj   +1 more source

Heterogeneity of Cancer‐Associated Fibroblasts and Precision Targeting Strategies for Cancer Therapy

Thoracic Cancer, Volume 17, Issue 11, June 2026.
CAFs orchestrate tumor immunosuppression through spatially organized ECM remodeling, cytokine signaling, and metabolic reprogramming. Targeting CAFs requires a shift from marker‐based depletion to functional state and niche‐specific intervention. ABSTRACT Immune checkpoint blockade (ICB) has transformed cancer therapy, but its effect is often limited ...
Yijie Wang, Guangyao Zhou, Pengpeng Zhang, Zhenfa Zhang, Lianmin Zhang   +4 more
wiley   +1 more source

Domain II of Pseudomonas Exotoxin Is Critical for Efficacy of Bolus Doses in a Xenograft Model of Acute Lymphoblastic Leukemia

Toxins, 2018
Moxetumomab pasudotox is a fusion protein of a CD22-targeting antibody and Pseudomonas exotoxin. Minutes of exposure to Moxetumomab achieves similar cell killing than hours of exposure to a novel deimmunized variant against some acute lymphoblastic ...
Fabian Müller, Tyler Cunningham, Richard Beers, Tapan K. Bera, Alan S. Wayne, Ira Pastan   +5 more
doaj   +1 more source

Plant‐Produced Viral Nanoparticles Decorated with Nanobodies Against HER2 Improve Retention and Recruitment of Immune Cells in Solid Tumors

Advanced Healthcare Materials, Volume 15, Issue 18, 15 May 2026.
Potato virus X is a filamentous RNA plant virus that can be engineered into a molecular tool for cancer therapy. We produced genetically‐encoded virus‐derived nanoparticles decorated with nanobodies targeting cancer cell receptors, epidermal growth factor receptor (EGFR) and human epidermal growth factor 2 (HER2).
Enrique Lozano‐Sanchez, Miguel A. Moreno‐Gonzalez, Fernando Merwaiss, Nicole F. Steinmetz, José‐Antonio Daròs   +4 more
wiley   +1 more source

Mouse CD25-specific recombinant immunotoxin

We generated a mouse CD25 (mCD25)-specific recombinant immunotoxin termed anti-mCD25-PE38. Variable regions of a rabbit monoclonal antibody that specifically reacts to mCD25, but not to hCD25, were used to produce anti-mCD25-PE38.
Kobayashi, Kazuto
core   +1 more source

A Single-Domain Antibody-Based Anti-PSMA Recombinant Immunotoxin Exhibits Specificity and Efficacy for Prostate Cancer Therapy

, 2021
Prostate cancer (PCa) is the second most common cancer in men, causing more than 300,000 deaths every year worldwide. Due to their superior cell-killing ability and the relative simplicity of their preparation, immunotoxin molecules have great potential ...
Wenjing Li, Zhangyong Hong, Yue Nan, Li Cao, Shixiong Li, Qiyu Li, Yutong Xing, Keyuan Xu   +7 more
core   +1 more source