Results 81 to 90 of about 6,038 (211)

Everolimus enhances immunotoxin action through coordinated down-regulation of protein synthesis and is also effective in a tumor xenograft model.

, 2016
A. Confirmation results demonstrating that everolimus enhances the cellular toxicity of the HA22, SS1P and HB21PE40 immunotoxins in multiple cell types.
Lesley Mathews Griner (2851961), Antonella Antignani (3074406), Evan Angelus (3074412), Manjie Huang (3074409), David J. FitzGerald (3074403), Nathan Simon (3074400), Matteo Pasetto (3074415), Craig J. Thomas (17880), Rajarshi Guha (182356), Ira Pastan (303807), Jonathan Keller (2400), Marc Ferrer (191300)   +11 more
core   +1 more source

Protein Synthesis Inhibition Activity of Mesothelin Targeting Immunotoxin LMB-100 Decreases Concentrations of Oncogenic Signaling Molecules and Secreted Growth Factors

Toxins, 2018
LMB-100 is a mesothelin-targeted recombinant immunotoxin (iTox) that carries a modified Pseuodomonas exotoxin A (PE) payload. PE kills cells by inhibiting synthesis of new proteins.
Salma El-Behaedi, Rebekah Landsman, Michael Rudloff, Emily Kolyvas, Rakan Albalawy, Xianyu Zhang, Tapan Bera, Keith Collins, Serguei Kozlov, Christine Alewine   +9 more
doaj   +1 more source

A Phase I study of an intravesically administered immunotoxin targeting EpCAM for the treatment of nonmuscle-invasive bladder cancer in BCG-refractory and BCG-intolerant patients

, 2010
Mark Kowalski1, Joycelyn Entwistle2, Jeannick Cizeau2, Demi Niforos1, Shauna Loewen2, Wendy Chapman1, Glen C MacDonald21Viventia Biotechnologies Inc., Mississauga, ON, Canada; 2Viventia Biotechnologies Inc., Winnipeg, MB, CanadaPurpose: A Phase I dose ...
Mark Kowalski, null Jocelyn Entwistle, Joycelyn Entwistle, null Mark Kowalski, Jeannick Cizeau, null Jeannick Cizeau, et al, null Shauna Loewen, null Wendy Chapman, null Demi Niforos, null MacDonald   +10 more
core   +2 more sources

Immunotoxins and Anticancer Drug Conjugate Assemblies: The Role of the Linkage between Components

Toxins, 2011
Immunotoxins and antibody-drug conjugates are protein-based drugs combining a target-specific binding domain with a cytotoxic domain. Such compounds are potentially therapeutic against diseases including cancer, and several clinical trials have shown ...
Luigi Cattel, Paola Brusa, Franco Dosio
doaj   +1 more source

Targeted Toxins in Brain Tumor Therapy

Toxins, 2010
Targeted toxins, also known as immunotoxins or cytotoxins, are recombinant molecules that specifically bind to cell surface receptors that are overexpressed in cancer and the toxin component kills the cell.
Walter A. Hall, Yan Michael Li
doaj   +1 more source

Improvement of a Recombinant Anti-Monkey Anti-CD3 Diphtheria Toxin Based Immunotoxin by Yeast Display Affinity Maturation of the scFv

, 2016
Recently, a bivalent recombinant anti-human CD3 diphtheria toxin (DT) based immunotoxin derived from the scFv of UCHT1 antibody has been made that shows enhanced bioactivity and is free from the side effects of Fc receptor interaction.
Zhirui Wang (629192), Yuan Yi Liu (2491810), Scott Stavrou (2491813), Jung-Hee Woo (2491807), David M. Neville (2491816), Geun-Bae Kim (2491804), Askale Mathias (2491801)   +6 more
core   +1 more source

Site-Specific PEGylation of Recombinant Immunotoxin DAB389IL-2: Structural and Functional Assessment

Research in Molecular Medicine, 2019
Background: DAB389IL-2 is considered a fusion immunotoxin and it is used for the CTCL therapy. DAB389IL-2 includes of two distinct portions; the catalytic domain of diphtheria toxin and IL-2. DAB389IL-2 duo to the presence of a free cysteine residue (Cys
Nasrin Zarkar, Mohammad Ali Nasiri Khalili, Sirus Khodadadi, Mehdi Zeinoddini, Maryam Ghodrati Siahmazgi, Nasrin Faramarzi   +5 more
doaj  

Mechanism of triterpenoid saponin mediated augmentation of saporin based immunotoxin cytotoxicity

, 2019
Immunotoxins are hybrid molecules comprised of a protein toxin molecule and a monoclonal antibody that selectively delivers the toxin to antigen expressing cells.
Wensley, Harrison James
core  

Tailoring Immunotoxin AS Anticancer Drug [PDF]

, 1989
The conventional treatments for cancer have been considered unsatisfatory, with limited efficiency in terms of discriminative cancer cell adverse reaction against the normal compartments, a number of immunological approaches had been implemented.
Asikin, N. (Nur), Cornain, S. (Santoso), Suryana, E. J. (Enud), Azis, F. (Farid), Hambali, H. (Hambali), Baziad, A. (Ali), Huda, N. (Nur)   +6 more
core  

Targeted Diphtheria Toxin-Based Therapy: A Review Article

Frontiers in Microbiology, 2019
Cancer remains one of the leading causes of death worldwide. Conventional therapeutic strategies usually offer limited specificity, resulting in severe side effects and toxicity to normal tissues.
Fatemeh Shafiee, Marc G. Aucoin, Ali Jahanian-Najafabadi   +2 more
doaj   +1 more source