Results 101 to 110 of about 6,038 (211)

Clinical Development of Experimental Therapies for Malignant Glioma

Sultan Qaboos University Medical Journal, 2011
Advances in medical and surgical treatments in the last two to three decades have resulted in quantum leaps in the overall survival of patients with many types of non-central nervous system (CNS) malignant disease, while survival of patients with ...
Nikolai G Rainov, Volkmar Heidecke
doaj  

Immunotoxin mediated killing of clonable T-lymphocytes infiltrating an irreversibly rejected human renal allograft

, 1989
We isolated and treated in vitro with a novel CD5-specific saporin immunotoxin, referred to as OKT1-SAP, the cells infiltrating an irreversibly rejected renal allograft from a patient who rejected while on cyclosporine plus steroids and then failed to ...
S. Siena, M. Bregni, D. A. Lappi, G. Bonadonna, A. M. Gianni, A. Formosa, B. Brando   +6 more
core  

Data for Mechanism of Triterpenoid Saponin Mediated Augmentation of Saporin Based Immunotoxin Cytotoxicity

Dataset for the thesis: Mechanism of Triterpenoid Saponin Mediated Augmentation of Saporin Based Immunotoxin ...
Flavell, David J., Wensley, Harrison, James   +1 more
core   +1 more source

Induction and increase of HLA-DR antigen expression by immune interferon on ML-3 cell line enhances the anti-HLA-DR immunotoxin activity

, 1990
SUMMARY In order to evaluate the impact of induction and increase target antigen expression on immunotoxin potency, we measured the potentiating effect of recombinant immune interferon-gamma (rIFN-γ) on the cytotoxicity of an anti HLA-DR ...
C BORDIER, F ROUBINET, M BRANDELY, G LAURENT, J P JAFFREZOU, C XAVIER, P CARAYON, M CHIRON   +7 more
core   +1 more source

Computational Design and Evaluation of scFv-DSH2a as a PSMA-Targeted Immunotoxin for Prostate Cancer Therapy: Computational design of scFv-DSH2a as a PSMA-targeted immunotoxin

Prostate cancer is one of the most prevalent malignancies in men and a leading cause of cancer-related mortality. The prostate-specific membrane antigen (PSMA), which is highly overexpressed in prostate tumors and internalized upon ligand binding ...
Mousavipour, Sara, Mousavi-Niri, Neda
core   +1 more source

Enhancing immunotoxin cell-killing activity via combination therapy with ABT-737.

, 2011
Immunotoxins are antibody-toxin fusion proteins directed to kill cancer cells displaying specific target antigens on their surface. Remarkably, immunotoxins directed to CD22 on hairy cell leukemia have produced complete remissions in approximately 60% of
Wayne, Alan, Ben-Josef, G, Sharma, A, Alan Wayne, Pastan, I, Antignani, Antonella, Tara Tendler, Gal Ben-josef, Ira Pastan, Fitzgerald, David J, Antignani, A, Francis Mussai, Kreitman, RJ, Robert J. Kreitman, Traini, R, Ben-Josef, Gal, Moskatel, Elizabeth, Traini, Roberta, Fitzgerald, DJ, Tendler, Tara, Mussai, Francis, Moskatel, E, Mussai, F, Roberta Traini, Ashima Sharma, Antonella Antignani, Tendler, T, David J. Fitzgerald, Kreitman, Robert J, Pastan, Ira, Sharma, Ashima, Wayne, A, Elizabeth Moskatel   +32 more
core   +1 more source

Recombinant CD64-specific single chain immunotoxin exhibits specific cytotoxicity against acute myeloid leukemia cells

, 2022
S.8414-8419CD64, the high affinity receptor for IgG (FcgammaRI) is expressed on acute myeloid leukemia blast cells and has recently been described as a specific target for immunotherapy.
Huhn, M., Winkel, J.G. van de, Thepen, T., Stocker, M., Vogel, S., Fischer, R., Tur, M.K., Barth, S., Jost, E., Osieka, R., Krohn, R., Finnern, R.   +11 more
core  

Diphtheria toxin‐based anti‐human CD19 immunotoxin for targeting human CD19+ tumors

, 2017
CD19 is expressed on normal and neoplastic B cells and is a promising target for immunotherapy. However, there is still an unmet need to further develop novel therapeutic drugs for the treatment of the refractory/relapsing human CD19+ tumors.
Huang, Qi, Sachs, David, Huang, Christene, Zheng, Qian, Madsen, Joren, Wang, Zhirui, Wang, Zhaohui, Zhang, Huiping   +7 more
core   +1 more source

Efficient in vivo antitumor effect of an immunotoxin based on ribotoxin α-sarcin in nude mice bearing human colorectal cancer xenografts

, 2015
Tagging of RNases, such as the ribotoxin α-sarcin, with the variable domains of antibodies directed to surface antigens that are selectively expressed on tumor cells endows cellular specificity to their cytotoxic action.
Olombrada Sacristán, Miriam, José G Gavilanes, Tomé-Amat, Jaime, Álvaro Martínez-del-Pozo, Clara Andradas, Olombrada, Miriam, Andradas, Clara, Eduardo Pérez-Gómez, Tomé Amat, Jaime, Sánchez, Cristina, Martínez, Leopoldo, Lacadena, Javier, Ruiz-de-la-Herrán, Javier, Miriam Olombrada, Ruiz de la Herrán, Javier, Andradas Arias, Clara, Cristina Sánchez, Martínez Del Pozo, Álvaro, Lacadena García-Gallo, Francisco Javier, Gavilanes, José G., Jaime Tomé-Amat, Javier Lacadena, Martínez-Del-Pozo, Álvaro, Gavilanes, José G, Javier Ruiz-de-la-Herrán, Pérez Gómez, Eduardo, Pérez-Gómez, Eduardo, Leopoldo Martínez, Sánchez García, María Cristina   +28 more
core   +1 more source

immunotoxin

Citation: 'immunotoxin' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13326 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source