Results 11 to 20 of about 10,277 (200)
CD30 as a Target Molecule in the Diagnosis and Therapy of Lymphomas. [PDF]
Am J HematolABSTRACT The tumor necrosis factor (TNF)‐receptor superfamily 8 receptor CD30 molecule is expressed in all tumor cells of Hodgkin lymphoma and anaplastic large cell lymphoma but is only weakly expressed in a small subset of large lymphoid cells in normal peripheral lymphoid tissues.
Stein H, Falini B.
europepmc +2 more sources
Combination treatments with the PKC inhibitor, enzastaurin, enhance the cytotoxicity of the anti-mesothelin immunotoxin, SS1P. [PDF]
PLoS ONE, 2013 Activated protein kinase C (PKC) contributes to tumor survival and proliferation, provoking the development of inhibitory agents as potential cancer therapeutics.
Abid R Mattoo +2 more
doaj +1 more source
Rivers of Tears - Convergent, Multi-Scale Approaches to Monitor and Optimize the Health of Our World's Inhabitants. [PDF]
Glob ChallProbing and sustaining the health of Earth's ecosystems and their inhabitants requires convergent approaches at multiple length and time scales. Predictive computational and physical modeling, together with novel biotechnologies applied in unexpected ways, are paving the way for discoveries at the intersection of epidemiology and geospatial science ...
Anderson EJ +6 more
europepmc +2 more sources
New and emerging therapeutic options for malignant pleural mesothelioma: review of early clinical trials. [PDF]
, 2015 Malignant pleural mesothelioma (MPM) is a rare tumor that is challenging to control. Despite some benefit from using the multimodality-approach (surgery, combination chemotherapy and radiation), survival remains poor. However, current research produced a
Cameron, Robert B +2 more
core +2 more sources
Novel Chemokine-Based Immunotoxins for Potent and Selective Targeting of Cytomegalovirus Infected Cells [PDF]
, 2017 Immunotoxins as antiviral therapeutics are largely unexplored but have promising prospective due to their high selectivity potential and their unparalleled efficiency.
Jeppesen, Mads G. +5 more
core +8 more sources
Frontiers in Oncology, 2022 Targeted therapies hold promise for efficiently and accurately delivering cytotoxic drugs directly to tumor tissue to exert anticancer effects. CD47 is a membrane protein expressed in a variety of malignant tumors and hematopoietic cells, which plays a ...
Zu-Chian Chiang +11 more
doaj +1 more source
Nanobody based dual specific CARs [PDF]
, 2018 Recent clinical trials have shown that adoptive chimeric antigen receptor (CAR) T cell therapy is a very potent and possibly curative option in the treatment of B cell leukemias and lymphomas.
Abken, Hinrich +8 more
core +2 more sources
BioTechniques, 2003 A major problem encountered in the large-scale purification of the bivalent anti-T cell immunotoxin, A-dmDT390-bisFv(G4S), from Pichia pastoris supernatants was the presence of host glycoproteins exhibiting similar charge, size, and hydrophobicity ...
Jung Hee Woo, David M. Neville
doaj +1 more source
The future of antiviral immunotoxins [PDF]
, 2016 There is a constant need for new therapeutic interventions in a wide range of infectious diseases. Over the past few years, the immunotoxins have entered the stage as promising antiviral treatments.
Høy Jakobsen, Mette +3 more
core +1 more source
Anti-tumoral potential of a human granulysin-based, CEA-targeted cytolytic immunotoxin
OncoImmunology, 2019 Granulysin is a protein present in the granules of human cytotoxic T lymphocytes (CTL) and natural killer (NK) cells, with cytolytic activity against microbes and tumors.
Raquel Ibáñez-Pérez +11 more
doaj +1 more source