Results 21 to 30 of about 4,550 (156)

Development of Novel CD47-Specific ADCs Possessing High Potency Against Non-Small Cell Lung Cancer in vitro and in vivo

Frontiers in Oncology, 2022
Targeted therapies hold promise for efficiently and accurately delivering cytotoxic drugs directly to tumor tissue to exert anticancer effects. CD47 is a membrane protein expressed in a variety of malignant tumors and hematopoietic cells, which plays a ...
Zu-Chian Chiang, Zu-Chian Chiang, Zu-Chian Chiang, Shubin Fang, Yang-kun Shen, Dongya Cui, Huanjiao Weng, Dawei Wang, Yuxiang Zhao, Jizhen Lin, Jizhen Lin, Qi Chen   +11 more
doaj   +1 more source

Anti-tumoral potential of a human granulysin-based, CEA-targeted cytolytic immunotoxin

OncoImmunology, 2019
Granulysin is a protein present in the granules of human cytotoxic T lymphocytes (CTL) and natural killer (NK) cells, with cytolytic activity against microbes and tumors.
Raquel Ibáñez-Pérez, Patricia Guerrero-Ochoa, Sameer Al-Wasaby, Rocío Navarro, Antonio Tapia-Galisteo, Diego De Miguel, Oscar Gonzalo, Blanca Conde, Luis Martínez-Lostao, Ramón Hurtado-Guerrero, Laura Sanz, Alberto Anel   +11 more
doaj   +1 more source

Separation of bivalent anti-T cell immunotoxin from Pichia pastoris glycoproteins by borate anion exchange

BioTechniques, 2003
A major problem encountered in the large-scale purification of the bivalent anti-T cell immunotoxin, A-dmDT390-bisFv(G4S), from Pichia pastoris supernatants was the presence of host glycoproteins exhibiting similar charge, size, and hydrophobicity ...
Jung Hee Woo, David M. Neville
doaj   +1 more source

Construction, Expression, and Characterization of a Recombinant Immunotoxin Targeting EpCAM

Mediators of Inflammation, 2015
Epithelial cell adhesion molecule (EpCAM) is a type I transmembrane glycoprotein overexpressed in human epithelioma but with relatively low expression in normal epithelial tissues.
Minghua Lv, Feng Qiu, Tingting Li, Yuanjie Sun, Chunmei Zhang, Ping Zhu, Xiaokun Qi, Jun Wan, Kun Yang, Kui Zhang   +9 more
doaj   +1 more source

Optimization of the Refolding Process for Recombinant Anti-EGFR Immunotoxin Produced in the Escherichia coli

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2021
Introduction: Overexpression of the EGFR is associated with carcinogenesis, and it is observed in more than 70% of head and neck cancers. The expression of an immunotoxin against EGFR designed as an alternative to full antibody led to the production of ...
Bahman Akbari
doaj  

IL-13Rα2 Status Predicts GB-13 (IL13.E13K-PE4E) Efficacy in High-Grade Glioma

Pharmaceutics, 2022
High-grade gliomas (HGG) are devastating diseases in children and adults. In the pediatric population, diffuse midline gliomas (DMG) harboring H3K27 alterations are the most aggressive primary malignant brain tumors. With no effective therapies available,
Julian S. Rechberger, Kendra A. Porath, Liang Zhang, Cody L. Nesvick, Randy S. Schrecengost, Jann N. Sarkaria, David J. Daniels   +6 more
doaj   +1 more source

Engineering and production of recombinant bovine pancreatic ribonuclease enzyme (RNase A) as a potential therapeutic [PDF]

مجله بیوتکنولوژی کشاورزی, 2021
Objective  Immunotoxins are one of the most promising ways in therapeutic fields, specially cancer therapy which have a unique toxin-antibody structure, and kill the cancer cell by passing through the cell membrane and entering the target cell.
Masoume Vakili-Azghandi, Mohammadreza Nassiri, Shahrokh Ghovvati, Ali Javadmanesh   +3 more
doaj   +1 more source

Depletion of Alloreactive T-Cells by Anti-CD137-Saporin Immunotoxin

Cell Transplantation, 2015
Depletion of alloreactive T-lymphocytes from allogeneic bone marrow tansplants may prevent graft-versus-host disease (GVHD) without impairing donor cell engraftment, immunity, and the graft-versus-leukemia (GVL) effect.
Sang C. Lee, Kwang W. Seo, Hye J. Kim, Sang W. Kang, Hye-Jeong Choi, Ansuk Kim, Byoung S. Kwon, Hong R. Cho, Byungsuk Kwon   +8 more
doaj   +1 more source

Mab-Zap: A Tool for Evaluating Antibody Efficacy for Use in an Immunotoxin

BioTechniques, 2000
Immunotoxins, consisting of antibodies coupled to toxins, are extremely useful tools in the elimination of specific cell populations in vitro and in vivo for research and therapeutic applications.
Matthew D. Kohls, Douglas A. Lappi
doaj   +1 more source

Rivers of Tears - Convergent, Multi-Scale Approaches to Monitor and Optimize the Health of Our World's Inhabitants. [PDF]

Glob Chall
Probing and sustaining the health of Earth's ecosystems and their inhabitants requires convergent approaches at multiple length and time scales. Predictive computational and physical modeling, together with novel biotechnologies applied in unexpected ways, are paving the way for discoveries at the intersection of epidemiology and geospatial science ...
Anderson EJ, Sansalone V, Lee LP, Grainger R, Lee S, Juhasz AL, Knothe Tate ML.   +6 more
europepmc   +2 more sources