Results 41 to 50 of about 7,988 (196)
Development of a recombinant antibody to target peptides and proteins to sialoadhesin-expressing macrophages [PDF]
, 2013 Background: Sialoadhesin (Sn)-expressing monocytes/macrophages have been associated with several diseases like inflammatory and autoimmune disorders as well as viral infections, and they also appear to play a role in the initiation of an adaptive immune ...
Delputte, Peter +4 more
core +2 more sources
Biotherapy, 1991 Immunotoxins (ITs) are chimeric molecules constructed by covalently conjugating monoclonal antibodies (MoAbs) to plant or bacterial toxins (e.g. ricin or pseudomonas exotoxin). The antibody moiety allows specific targeting of ITs to tumor-associated antigens, while the toxin moiety is responsible for cell killing by irreversible inactivation of protein
openaire +4 more sources
Ribosome-Inactivating Proteins from Plants: A Historical Overview
Molecules, 2016 This review provides a historical overview of the research on plant ribosome-inactivating proteins (RIPs), starting from the first studies at the end of eighteenth century involving the purification of abrin and ricin, as well as the immunological ...
Andrea Bolognesi +4 more
doaj +1 more source
Single-domain antibodies and their formatting to combat viral infections [PDF]
, 2018 Since their discovery in the 1990s, single-domain antibodies (VHHs), also known as NanobodiesA (R), have changed the landscape of affinity reagents. The outstanding solubility, stability, and specificity of VHHs, as well as their small size, ease of ...
Ballegeer, Marlies +4 more
core +2 more sources
Toxins, 2016 The toxic moiety of almost all protein-based targeted toxins must enter the cytosol of the target cell to mediate its fatal effect. Although more than 500 targeted toxins have been investigated in the past decades, no antibody-targeted protein toxin has ...
Hendrik Fuchs +2 more
doaj +1 more source
Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines
Advanced Science, EarlyView.Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira +18 more
wiley +1 more source
Dianthin and Its Potential in Targeted Tumor Therapies [PDF]
, 2019 Dianthin enzymes belong to ribosome-inactivating proteins (RIPs) of type 1, i.e., they only consist of a catalytic domain and do not have a cell binding moiety.
Fuchs, Hendrik
core +1 more source
Asia-Pacific Journal of Chemical Engineering, EarlyView.ABSTRACT Photocatalytic materials have emerged as promising solutions for environmental applications due to their ability to degrade organic pollutants under sunlight or artificial light. In this review, recent progress on the photocatalytic materials used for the degradation of pharmaceutical personal care products (PPCPs) in environmental ...
Urvashi Sen +5 more
wiley +1 more source
An Old Idea Tackling a New Problem: Targeted Toxins Specific for Cancer Stem Cells
Antibodies, 2013 Targeting and killing specific cells discriminately has been the goal of targeted therapy dating back to the era of Paul Ehrlich. The discovery of cancer stem cells has caused a paradigm shift within the cancer field and provided an opportunity to use ...
Daniel A. Vallera, Nate N. Waldron
doaj +1 more source
Cellular Respiration in Thymic Fragments from Mice
Frontiers in Bioscience-Landmark, 2022 Background: This report aims to detail the use of the phosphorescence oxygen analyzer for in vitro investigation of thymic responses to pharmaceutical agents, in particular immunosuppressants and immunomodulators.
Mariam Alshamsi +3 more
doaj +1 more source