Results 61 to 70 of about 7,656 (201)
The CNS Meninges and the Synovial Joint: Parallel Immunological Structures in Autoimmune Disease
BioEssays, Volume 48, Issue 2, February 2026.The meninges and synovium share multiple functional and structural characteristics and act as specialized immunological barriers. In MS and RA, both can host tertiary lymphoid organs (TLOs) and CD4+ Tph cells. We highlight how these features sustain compartmentalized inflammation and explore a possible role for EBV in their formation and persistence ...
Mohamed Reda Fazazi, Manu Rangachari
wiley +1 more source
Codominance and toxins: A path to drugs of nearly unlimited selectivity [PDF]
, 1995 The effectiveness of drugs is often limited by their insufficient selectivity. I propose designs of therapeutic agents that address this problem. The key feature of these reagents, termed comtoxins (codominance-mediated toxins), is their ability to ...
Varshavsky, Alexander
core
Mesothelioma and thymic tumors: Treatment challenges in (outside) a network setting [PDF]
, 2019 The management of patients with mesothelioma and thymic malignancy requires continuous multidisciplinary expertise at any step of the disease. A dramatic improvement in our knowledge has occurred in the last few years, through the development of ...
Girard, N +4 more
core +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.A novel mouse model of mesial temporal lobe epilepsy (MTLE) with hippocampal sclerosis (HS) by unilateral, partial ablation of hippocampal GABAergic neurons is established. The model recapitulates key features of the human condition, including spontaneous recurrent seizures, HS‐like pathology, and associated cognitive deficits.
Ting Tang +10 more
wiley +1 more source
CD30 as a Target Molecule in the Diagnosis and Therapy of Lymphomas
American Journal of Hematology, Volume 101, Issue 1, Page 110-128, January 2026.ABSTRACT The tumor necrosis factor (TNF)‐receptor superfamily 8 receptor CD30 molecule is expressed in all tumor cells of Hodgkin lymphoma and anaplastic large cell lymphoma but is only weakly expressed in a small subset of large lymphoid cells in normal peripheral lymphoid tissues.
Harald Stein, Brunangelo Falini
wiley +1 more source
Development of an immunotoxin incorporating the Australian jumper ant toxin, pilosulin 1 [PDF]
, 2007 University of Technology, Sydney. Faculty of Science.Immunotoxins are therapeutic agents that directly target toxins to specific cells and are generally comprised of an antibody or antibody fragment (Fab or scFv) linked to a toxic moiety.
Lemke, Susan Jane
core
Exploring the Role of Acrylamide in Food Allergy via Dendritic Cell‐Dependent Th2 Immune Responses
Food Frontiers, Volume 7, Issue 1, January 2026.Acrylamide may disrupt immune tolerance as a foodborne immunotoxicant, priming allergic inflammatory susceptibility through DC‐dependent Th2/Th17 polarization, TLR4/NF‐κB signaling amplification, and IL‐10 production suppression. ABSTRACT Acrylamide (AA), a prevalent food processing contaminant with recognized multi‐organ toxicity, has an unexplored ...
Xue Feng +8 more
wiley +1 more source
Glycosylated Triterpenoids as Endosomal Escape Enhancers in Targeted Tumor Therapies
Biomedicines, 2017 Protein-based targeted toxins play an increasingly important role in targeted tumor therapies. In spite of their high intrinsic toxicity, their efficacy in animal models is low.
Hendrik Fuchs +6 more
doaj +1 more source
Efficacy of Combined 5-Fluorouracil and Photodynamic Therapy in Glioma Spheroids
, 2018 Standard treatment regimens consisting of surgery, radiation and chemotherapy have proven ineffective for the treatment of high-grade gliomas such as glioblastoma multiforme (GBM).
Singh, Karanjit
core +1 more source
Hemolytic Activity of pH-Responsive Polymer-Streptavidin Bioconjugates [PDF]
, 1999 Drug delivery systems that increase the rate and/or quantity of drug release to the cytoplasm are needed to enhance cytosolic delivery and to circumvent nonproductive cell trafficking routes. We have previously demonstrated that poly(2-ethylacrylic acid)
Hoffman, Allan S. +5 more
core +1 more source