Results 71 to 80 of about 7,988 (196)
Glycosylation of glycolipids in cancer: basis for development of novel therapeutic approaches [PDF]
, 2013 Altered networks of gene regulation underlie many pathologies, including cancer. There are several proteins in cancer cells that are turned either on or off, which dramatically alters the metabolism and the overall activity of the cell, with the complex ...
Daniotti, Jose Luis +4 more
core +2 more sources
MedComm – Oncology, Volume 4, Issue 4, December 2025.Parkinson's disease (PD) and glioma are neurological disorders with distinct and even opposing mechanisms: α‐synuclein deposition and neuronal loss in PD versus glial cell malignancy in glioma. Despite these differences, their contrasting pathologies highlight multiple therapeutic targets.
Tianli Pan +7 more
wiley +1 more source
Bouganin, an Attractive Weapon for Immunotoxins
Toxins, 2018 Bougainvillea (Bougainvillea spectabilis Willd.) is a plant widely used in folk medicine and many extracts from different tissues of this plant have been employed against several pathologies.
Massimo Bortolotti +2 more
doaj +1 more source
Chemical Screens Identify Drugs that Enhance or Mitigate Cellular Responses to Antibody-Toxin Fusion Proteins. [PDF]
PLoS ONE, 2016 The intersection of small molecular weight drugs and antibody-based therapeutics is rarely studied in large scale. Both types of agents are currently part of the cancer armamentarium.
Antonella Antignani +11 more
doaj +1 more source
Hemolytic Activity of pH-Responsive Polymer-Streptavidin Bioconjugates [PDF]
, 1999 Drug delivery systems that increase the rate and/or quantity of drug release to the cytoplasm are needed to enhance cytosolic delivery and to circumvent nonproductive cell trafficking routes. We have previously demonstrated that poly(2-ethylacrylic acid)
Hoffman, Allan S. +5 more
core +1 more source
Stimuli‐responsive systems: A focus on controlled drug delivery for posterior segment ocular disease
Responsive Materials, Volume 3, Issue 4, November 2025.This review highlights recent advances in stimuli‐responsive drug delivery for posterior segment diseases, focusing on mechanisms and potential. It also explores mechanically interlocked molecules and bioorthogonal reactions as novel approaches. Challenges and future perspectives are discussed, aiming to bridge the gap between research and clinical ...
Chengzhi Zhang +11 more
wiley +1 more source
Treatment with immunotoxin [PDF]
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2001 T–cell depletion prior to or beginning at the time of transplantation has been shown to be a valuable adjunct to the induction of immunological unresponsiveness. Both total lymphoid irradiation and anti–lymphocyte globulin have been used for this purpose in experimental models of transplantation as well as in human organ transplant recipients. However,
openaire +2 more sources
European Journal of Neuroscience, Volume 62, Issue 9, November 2025.The measurement of choline as a biomarker for in vivo cholinergic neurotransmission is a valuable tool in the study of a range of CNS disorders. However, the continuous detection of cholinergic neurotransmission in selective brain regions in the mouse brain remains challenging and underexploited.
Seán Doyle +3 more
wiley +1 more source
Targeted Diphtheria Toxin-Based Therapy: A Review Article
Frontiers in Microbiology, 2019 Cancer remains one of the leading causes of death worldwide. Conventional therapeutic strategies usually offer limited specificity, resulting in severe side effects and toxicity to normal tissues.
Fatemeh Shafiee +2 more
doaj +1 more source
Botulinum neurotoxin type C protease induces apoptosis in differentiated human neuroblastoma cells [PDF]
, 2016 Neuroblastomas constitute a major cause of cancer-related deaths in young children. In recent years, a number of translation-inhibiting enzymes have been evaluated for killing neuroblastoma cells. Here we investigated the potential vulnerability of human
Binz, T. +3 more
core +1 more source