Results 141 to 150 of about 27,781 (266)
Chemical and Biological Properties of Hymenaea courbaril L.: A Review
PRISMA‐style flowchart showing the screening process of studies identified and selected in the review has been added to the attachments. ABSTRACT Hymenaea courbaril L., commonly known as jatobá, is a plant traditionally used by native populations for medicinal purposes, in addition to providing edible fruits and durable wood for construction.
Cicera Alane Coelho Gonçalves +6 more
wiley +1 more source
Endonuclease V: From Transcriptome Regulator to Chemical Biology Tool
Post‐transcriptional modifications play a pivotal role in regulating the health and physiology of human cells, and adenosine‐to‐inosine (A‐to‐I) editing is one of the most abundant of these modifications. Inosine is read as guanosine by the cellular machinery, and this change impacts both the regulation and genetic code of RNA, in turn effectively ...
Prasanth Thota +5 more
wiley +1 more source
Stroke is a neurological impairment caused by vascular injury of the central nervous system, and globally, stroke is ranked as the second most common cause of death and disability. Numerous risk factors, disease processes, and mechanisms can contribute to stroke, which is not a single disease. G.
Ali Ikram +6 more
wiley +1 more source
Studies on molecular epidemiological biomarkers in oro-pharyngeal tumors. Animal experiments and molecular epidemiological studies. [PDF]
A szájüregi (oro-faringeális) rák pontos meghatározása a szakirodalomban is vitatott. Szájüregi rákon a betegségek nemzetközi osztályozása (BNO) szerint az ajak, a szájüreg és a garat C00-C14 kódszámokkal megjelölt ...
Németh Árpád
core
Computational Algorithmic Innovations in Differential Equation‐Based Dynamic Process Modeling
This study presents algorithmic innovations in Neural Ordinary Differential Equations (NeuralODEs) for dynamic process modeling of complex biochemical systems. Using the DARPP‐32 signaling network as a benchmark, the proposed framework demonstrates accurate replication of ODE and Rule‐Based Model behaviors while offering enhanced modularity ...
Guobin Zeng
wiley +1 more source
Oxidative Stress: Molecular Mechanisms, Diseases, and Therapeutic Targets
Oxidative stress occurs when the reactive oxygen species (ROS) production overwhelms the ROS scavenging, which lead to genomic instability, epigenetic regulation, proteostasis imbalance, and lipid peroxidation, subsequently causing the occurrence and development of numerous diseases. ABSTRACT Although the physiological level of reactive oxygen species (
Yi Qin +10 more
wiley +1 more source
Progress in RNA‐Targeted Therapeutics for Human Diseases
RNA‐targeted therapies are revolutionizing molecular medicine by transitioning from a “protein‐centric” focus to an “RNA‐regulatory network” approach. Leveraging RNA's diverse roles in gene regulation, signaling, and epigenetic modifications, advanced platforms such as ASOs, siRNA, miRNA, mRNA, aptamers, shRNA, and CRISPR/Cas systems are enabling ...
Wangzheqi Zhang +10 more
wiley +1 more source
Collection and Evaluation of (Q)SAR Models for Mutagenicity and Carcinogenicity [PDF]
This evaluation of the non-commercial (Q)SARs for mutagenicity and carcinogenicity consisted of a preliminary survey (Phase I), and then of a more detailed analysis of short listed models (Phase II).
BENIGNI Romualdo +3 more
core
Inhibiting the SUMOylation modification of TRPM4 can prevent the vascular endothelial damage caused by ATO. Inhibition of TRPM4 SUMOylation, either pharmacologically by GA or genetically by the K618R mutation, protects against ATO‐induced vascular endothelial damage.
Ting‐Ting Tong +18 more
wiley +1 more source
Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging
Mouse models revealed age‐associated increased circumferential stiffness of the proximal pulmonary artery that was associated with reorientation of collagen and decreased function of the lung and right ventricle. Age‐related transcriptional changes were indicative of senescence, ECM turnover, TGFβ signaling, and altered intercellular signaling among ...
Ruben De Man +22 more
wiley +1 more source

