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Mutagenicity studies with 6-mercaptopurine: I. Cytogenetic activity in vivo
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1973Abstract Cytogenetic studies have been performed to determine the effect of 6-mercaptopurine (6-MP) on mammalian chromosomes in vivo . An elevated level of chromosome breakage is present in mouse bone marrow cells within 12 h after oral or parenteral dosing with 200 mg/kg.
H E, Holden +3 more
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Mutagenicity detection of in vivo nitrosation of dimethylamine by nitrite
Environmental Mutagenesis, 1979AbstractIn vivo nitrosation of dimethylamine by nitrite was measured with an intrahepatic host‐mediated mutagenicity assay using Salmonella typhimurium as the detecting organism. It was possible to detect the product, N‐nitrosodimethylamine, at much lower doses with this system than with previously reported in vivo systems.
W Z, Whong, N D, Speciner, G S, Edwards
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In vitro and in vivo mutagenicity studies with airborne particulate extracts
Mutation Research/Genetic Toxicology, 1988The contribution of nitro compounds to airborne particulate mutagenicity was studied with Salmonella typhimurium strains TA98, TA98NR, TA98/1,8DNP6. The results obtained indicate that nitropyrenes play a minor role in air particulate mutagenicity. Seasonal variations indicate a relatively greater contribution of nitro compounds to the mutagenicity of ...
R, Crebelli +8 more
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Mutagenicity of dimethylsulfoxide (DMSO): In vivo cytogenetics study in the rat
Teratogenesis, Carcinogenesis, and Mutagenesis, 1981AbstractVarious concentrations (1%, 10%, 50%, and 100%) of laboratory grade dimethylsulfoxide (DMSO) were administered by intraperitoneal injection to male Sprague‐Dawley rats for five consecutive days. Femoral bone marrow cells were harvested 24 hours after the last injection and were analyzed for cytogenetic aberration frequencies including ...
R W, Kapp, B E, Eventoff
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Archives of Toxicology, 2018
1,4-Dioxane is a widely used synthetic industrial chemical and its contamination of drinking water and food is a potential health concern. It induces liver tumors when administered in the drinking water to rats and mice. However, the mode of action (MOA) of the hepatocarcinogenicity of 1,4-dioxane remains unclear.
Min Gi +9 more
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1,4-Dioxane is a widely used synthetic industrial chemical and its contamination of drinking water and food is a potential health concern. It induces liver tumors when administered in the drinking water to rats and mice. However, the mode of action (MOA) of the hepatocarcinogenicity of 1,4-dioxane remains unclear.
Min Gi +9 more
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Mutagenicity of Selected Chemicals in In Vivo Cytogenetic Assays
1981There are a variety of test systems available for the analysis of chromosome aberrations following in vivo treatment. There are advantages and disadvantages to each, which means that the information obtained from any one test must be critically examined. Because of the variety of test systems employed, it is also impossible to provide a concise summary
R. J. Preston +3 more
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[Mutagen-modifying effects of beta-carotene in vivo].
Genetika, 1997A chromosome aberration test on bone marrow cells of C57B1/6 mice showed that beta-carotene (BC) applied by oral administration as a E160a food dye (30% oil suspension) at doses of 0.5, 5, and 50 mg/kg simultaneously with cyclophosphamide (CPA) and dioxidine (DN) injected intraperitoneally for a period of 24 h did not modify their clastogenic effects ...
A D, Durnev +4 more
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In vivo mutagenicity of hexavalent chromium
Mutation Research/Environmental Mutagenesis and Related Subjects, 1995S. Itoh, H. Shimada
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Mutagenicity tests on epristeride in vitro and in vivo.
Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1999To evaluate the genetic effects of epristeride (Epr), a new prospective drug for treating benign prostatic hyperplasia.1) Assaying reverse mutation in histidine nutritional deficiency strain of Salmonella typhimurium 2) detecting chromosome aberrations in Chinese hamster lung cells (CHL); 3) micronucleus assays of mouse bone marrow; 4) counting sperm ...
X L, Wang +4 more
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