Physiological Reports, 2019 Bariatric surgery is now the most widely used intervention for the treatment of human obesity. A large body of literature has demonstrated its efficacy in sustained weight loss and improvement in its associated comorbidities.
Isabel Casimiro +2 more
exaly +3 more sources
Endokrynologia Polska, 2021 INTRODUCTION: The effect of incretins including dipeptidyl peptidase 4 inhibitors (DPP4-Is) and glucagon-like peptide1 receptor agonists (GLP1-ras) in the treatment of type 2 diabetes increasing the risk of fracture remains controversial.
Qing-xin Kong +5 more
doaj +2 more sources
Bile acids and incretins as modulators of obesity-associated atherosclerosis [PDF]
Frontiers in Cardiovascular MedicineObesity is one of the major global health concerns of the 21st century, associated with many comorbidities such as type 2 diabetes mellitus (T2DM), metabolic dysfunction-associated steatotic liver disease, and early and aggressive atherosclerotic ...
Andrijana Kirsch +4 more
doaj +2 more sources
Deciphering obesity: a conceptual overview and synthesis [PDF]
Frontiers in EndocrinologyObesity represents a multifactorial disorder rooted in genetic, developmental, and environmental influences. Its persistence and heterogeneity warrant deeper understanding of pathology beyond genetic determinism. This Perspective synthesizes a conceptual
Rashmi Prakash +3 more
doaj +2 more sources
Glucagon-like peptide-1 receptor agonists and the endothelium: molecular and clinical insights into cardiovascular protection [PDF]
Frontiers in MedicineEndothelial dysfunction represents the critical pathophysiological mediator linking the modern epidemics of obesity, type 2 diabetes mellitus, and cardiovascular disease.
Allegra Battistoni +5 more
doaj +2 more sources
Association between plasma glucose-dependent insulinotropic polypeptide and active adiponectin in normoglycemic women [PDF]
Endocrine ConnectionsBackground/objectives: Glucose-dependent insulinotropic polypeptide (GIP) is secreted by enteroendocrine K cells in response to nutrient ingestion. The aims of this study were: i) to evaluate the cross-sectional associations between plasma GIP change in ...
Isidora Salvatierra +6 more
doaj +2 more sources
Comparative effects of SGLT2 inhibitors and incretin-based therapies on dementia risk in type 2 diabetes: a systematic review and meta-analysis [PDF]
Frontiers in EndocrinologyBackgroundAntidiabetic drugs lower blood glucose levels and may also have neuroprotective and vascular protection effects. In particular, sodium–glucose cotransporter 2 inhibitors (SGLT2is) and incretin mimetics have demonstrated dementia-reducing ...
Kirim Song +10 more
doaj +2 more sources
Hyperglycaemia induced osteoporosis: Is there a hope with dipeptidyl peptidase-4 inhibitors?
Health Sciences Review, 2023 Diabetes mellitus and osteoporosis are chronic illnesses associated with adverse health outcomes. Studies have reported common linkages between energy and bone metabolism.
Faraha Ahmed +8 more
doaj +1 more source
Experimental and Emerging Free Fatty Acid Receptor Agonists for the Treatment of Type 2 Diabetes
Medicina, 2022 The current management of Type 2 Diabetes Mellitus (T2DM) includes incretin-based treatments able to enhance insulin secretion and peripheral insulin sensitivity as well as improve body mass, inflammation, plasma lipids, blood pressure, and ...
Angelo Maria Patti +10 more
doaj +1 more source
The Sensory Mechanisms of Nutrient-Induced GLP-1 Secretion
Metabolites, 2022 The enteroendocrine system of the gut regulates energy homeostasis through the release of hormones. Of the gut-derived hormones, GLP-1 is particularly interesting, as analogs of the hormone have proven to be highly effective for the treatment of type 2 ...
Anna Pii Hjørne +2 more
doaj +1 more source