Results 51 to 60 of about 22,864 (242)

Update on incretin hormones [PDF]

Annals of the New York Academy of Sciences, 2011
The incretin hormones glucagon‐like‐peptide‐1 (GLP‐1) and glucose‐dependent insulinotropic polypeptide (GIP) are released from the intestine following oral ingestion of nutrients. Incretins promote insulin secretion, while GLP‐1 also inhibits glucagon release and gastric emptying, minimizing postprandial glucose excursions.
Phillips, Liza K., Prins, Johannes B.
openaire   +3 more sources

Brain access of incretins and incretin receptor agonists to their central targets relevant for appetite suppression and weight loss

American Journal of Physiology. Endocrinology and Metabolism
Incretin-based pharmacotherapies provide novel efficient and safe therapeutic options to curb appetite and produce weight loss in obese patients. Delivered systemically, these molecules produce pleiotropic metabolic benefits, but the target sites ...
Sophie Buller, Clemence Blouet
semanticscholar   +1 more source

Role of GLP-1 receptor agonists in endothelial function [PDF]

, 2012
BACKGROUND: The leading cause of death for patients suffering from type 2 diabetes is macrovascular disease. Endothelial dysfunction is one of the earliest events identified in the pathogenesis of atherosclerosis.
Erdogdu, Özlem
core   +1 more source

Use of the oral sugar test in ponies when performed with or without prior fasting [PDF]

, 2016
Background It is recommended that the Oral Sugar Test (OST) for insulin dysregulation (ID) is performed after an overnight fast but fasting is impractical in ponies kept solely at pasture.
Bamford, Banse, Banse, Bartlett, Bland, Bland, Bland, Bland, Borer-Weir, Brightwell, Frank, Frank, Frank, Frank, Kim, Laat, Laat, Lindåse, Mooy, Pratt, Rendle, Schuver, Smith, Tinworth, Wylie   +24 more
core   +2 more sources

Glucagon-like peptide-1 analogues: An overview

Indian Journal of Endocrinology and Metabolism, 2013
Abnormalities of the incretin axis have been implicated in the pathogenesis of type 2 diabetes mellitus. Glucagon-like peptide-1 (GLP-1) and gastroinhibitory intestinal peptide constitutes >90% of all the incretin function.
Vishal Gupta
doaj   +1 more source

Endothelial Function in Pre-diabetes, Diabetes and Diabetic Cardiomyopathy: A Review [PDF]

, 2014
Diabetes mellitus worsens cardiovascular risk profile of affected individuals. Its worldwide increasing prevalence and its negative influences on vascular walls morphology and function are able to induce the expression of several morbidities which worsen
Cameli, Matteo, Cecere, Annagrazia, Matteo Ciccone, Marco, MATTIOLI, Anna Vittoria, Scicchitano, Pietro   +4 more
core   +1 more source

GLP-1 and GIP in Type 1 Diabetes Therapy: A Time for Reappraisal?

Diabetology
Incretin hormones, such as glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), are essential regulators of glucose homeostasis, energy balance, and metabolic communication between organs.
Grazia Piras, Sara Brasili, Davide Demontis, Leonardo Della Sala, Francesco Cocchiara, Davide Carlo Maggi, Anna Arecco   +6 more
doaj   +1 more source

The Sensory Mechanisms of Nutrient-Induced GLP-1 Secretion

Metabolites, 2022
The enteroendocrine system of the gut regulates energy homeostasis through the release of hormones. Of the gut-derived hormones, GLP-1 is particularly interesting, as analogs of the hormone have proven to be highly effective for the treatment of type 2 ...
Anna Pii Hjørne, Ida Marie Modvig, Jens Juul Holst   +2 more
doaj   +1 more source

Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. [PDF]

, 2013
Controversy exists regarding the potential regenerative influences of incretin therapy on pancreatic β-cells versus possible adverse pancreatic proliferative effects.
Atkinson, Mark, Butler, Alexandra E, Butler, Peter C, Campbell-Thompson, Martha, Dawson, David W, Gurlo, Tatyana   +5 more
core   +2 more sources

Problems of hypoglycemic therapy in diabetic patients with acute coronary syndrome

Медицинский совет, 2016
Patients with diabetes mellitus (DM) are classified as "vulnerable patients" suffering from acute coronary syndrome (ACS) 2-3 times more often and have a pessimistic prognosis compared with normoglycemic patients.
L. A. Ruyatkina, D. S. Ruyatkin, A. K. Ovsyannikova   +2 more
doaj   +1 more source