Results 61 to 70 of about 22,864 (242)
Incretin Hormones and Type 2 Diabetes—Mechanistic Insights and Therapeutic Approaches
Biology, 2020 Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are secreted from the gut upon nutrient stimulation and regulate postprandial metabolism.
Geke Aline Boer, Jens Juul Holst
doaj +1 more source
Metabolites, 2021 Insulin secretion is widely thought to be maximally stimulated in glucose concentrations of 16.7-to-30 mM (300-to-540 mg/dL). However, insulin secretion is seldom tested in hyperglycemia exceeding these levels despite the Guinness World Record being 147 ...
Katherine M. Gerber +5 more
doaj +1 more source
Apolipoprotein A-IV: a protein intimately involved in metabolism
Journal of Lipid Research, 2015 The purpose of this review is to summarize our current understanding of the physiological roles of apoA-IV in metabolism, and to underscore the potential for apoA-IV to be a focus for new therapies aimed at the treatment of diabetes and obesity-related ...
Fei Wang +5 more
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Cancer Biology and Prevention in Diabetes
Cells, 2020 The available evidence suggests a complex relationship between diabetes and cancer. Epidemiological data suggest a positive correlation, however, in certain types of cancer, a more complex picture emerges, such as in some site-specific cancers being ...
Swayam Prakash Srivastava +1 more
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Potential Therapeutic Strategies in the Treatment of Metabolic-Associated Fatty Liver Disease
Medicina, 2023 Metabolic-associated Fatty Liver Disease is one of the outstanding challenges in gastroenterology. The increasing incidence of the disease is undoubtedly connected with the ongoing obesity pandemic.
Aleksandra Bołdys +4 more
doaj +1 more source
Microbiota-Produced N-Formyl Peptide fMLF Promotes Obesity-Induced Glucose Intolerance. [PDF]
, 2019 The composition of the gastrointestinal microbiota and associated metabolites changes dramatically with diet and the development of obesity. Although many correlations have been described, specific mechanistic links between these changes and glucose ...
Chan, Luisa S +16 more
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Cardiovascular effects of Glucagon-like peptide 1 (GLP-1) receptor agonists [PDF]
, 2014 Patients with type 2 diabetes have a several-fold increased risk of developing cardiovascular disease when compared with nondiabetic controls. Myocardial infarction and stroke are responsible for 75% of all death in patients with diabetes, who present a ...
Andrei C Sposito, Francisco Kerr Saraiva
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Effects of meal and incretins in the regulation of splanchnic blood flow
Endocrine Connections, 2017 Objective Meal ingestion is followed by a redistribution of blood flow (BF) within the splanchnic region contributing to nutrient absorption, insulin secretion and glucose disposal, but factors regulating this phenomenon in humans are poorly known.
J. Koffert +11 more
semanticscholar +1 more source
Phenotyping of type 2 diabetes mellitus at onset on the basis of fasting incretin tone: Results of a two-step cluster analysis [PDF]
, 2015 Aims/Introduction: According to some authors, in type 2 diabetes there is a reduced postprandial action of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP).
Amato, M. +4 more
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Cirurgia metabólica - cura para diabete tipo 2 [PDF]
, 2011 INTRODUCTION: Type 2 diabetes is a metabolic disease characterized by chronic hyperglycemia associated with several organs damage and failure. It is the most common cause of blindness, amputation and kidney failure in western adults, besides increase the
Tomaz, Carlos Alberto Bezerra +1 more
core +3 more sources