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Novel small IncX3 plasmid carrying the blaKPC-2 gene in high-risk Klebsiella pneumoniae ST11/CG258
This study used whole-genome sequencing (WGS) and PFGE to analysis KPC-2-producing Klebsiella pneumoniae strains from clinical specimens collected in Brazilian hospitals. The study identifies the emergence of a novel small IncX3 plasmid (pKPB11), 12,757-bp in length, in a high-risk K.
Bruna Fuga +2 more
exaly +3 more sources
Impact of Plasmid-Encoded H-NS–like Protein on blaNDM-1-Bearing IncX3 Plasmid in Escherichia coli
AbstractBackgroundThis study was performed to assess the role of the histone-like nucleoid-structuring (H-NS)–like protein, carried by blaNDM-1-encoding IncX3-type plasmids, in the dissemination of IncX3 plasmids.MethodsThe blaNDM-1-encoding IncX3 plasmids were analyzed using southern blot, conjugation, and competition assays.
Kai Zhou, Qi Li
exaly +3 more sources
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Occurrence of blaNDM-7 within IncX3-type plasmid of Escherichia coli from India
Journal of Infection and Chemotherapy, 2017New-Delhi metallo-β-lactamase-7 with higher hydrolytic activity than its ancestor NDM-1 is emerging across the globe including India. In this study, we have investigated the genetic context of blaNDM-7 and alteration in plasmid copy number under concentration gradient carbapenem stress.Six blaNDM-7 producing Escherichia coli isolates were obtained from
Deepjyoti, Paul +6 more
openaire +2 more sources
Co-transfer of blaNDM-5 and mcr-1 by an IncX3–X4 hybrid plasmid in Escherichia coli
Nature Microbiology, 2016Carbapenem and colistin are the last-resort antibiotics used for treating multidrug-resistant Gram-negative pathogens. Here, we report, for the first time, co-transfer of resistance to both classes of antibiotics by a mobile IncX3-X4 hybrid plasmid in an Escherichia coli isolate.
Jian Sun, Qijing Zhang, Youjun Feng
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Microbial Drug Resistance, 2022
The spread of NDM-5-producing Escherichia coli has become a severe challenge in clinical therapy, which necessitates reliable detection and surveillance methods. However, limited information is available regarding the prevalence and dissemination of the blaNDM-5 gene in E. coli in China. Therefore, we investigated the dissemination of the blaNDM-5 gene
Xiaofeng, Hu +13 more
openaire +2 more sources
The spread of NDM-5-producing Escherichia coli has become a severe challenge in clinical therapy, which necessitates reliable detection and surveillance methods. However, limited information is available regarding the prevalence and dissemination of the blaNDM-5 gene in E. coli in China. Therefore, we investigated the dissemination of the blaNDM-5 gene
Xiaofeng, Hu +13 more
openaire +2 more sources
Journal of Medical Microbiology, 2013
Among 28 clinically relevant, carbapenem non-susceptible Enterobacteriaceae isolates collected in 2009–2011 in the United Arab Emirates three Klebsiella pneumoniae, two Escherichia coli, one Enterobacter cloacae and one Citrobacter freundi were identified to produce NDM-1 carbapenemase. Unexpectedly, with the exception of a K.
Agnes, Sonnevend +7 more
openaire +2 more sources
Among 28 clinically relevant, carbapenem non-susceptible Enterobacteriaceae isolates collected in 2009–2011 in the United Arab Emirates three Klebsiella pneumoniae, two Escherichia coli, one Enterobacter cloacae and one Citrobacter freundi were identified to produce NDM-1 carbapenemase. Unexpectedly, with the exception of a K.
Agnes, Sonnevend +7 more
openaire +2 more sources
Fitness Cost of blaNDM-5-Carrying p3R-IncX3 Plasmids in Wild-Type NDM-Free Enterobacteriaceae
Microorganisms, 2020Lei Lei, Weishuai Zhai, Yingbo Shen
exaly

