Results 1 to 10 of about 2,171 (161)

VirBR, a transcription regulator, promotes IncX3 plasmid transmission, and persistence of bla NDM-5 in zoonotic bacteria [PDF]

Nature Communications
IncX3 plasmids carrying the New Delhi metallo-β-lactamase-encoding gene, bla NDM-5, are rapidly spreading globally in both humans and animals. Given that carbapenems are listed on the WHO AWaRe watch group and are prohibited for use in animals, the ...
Tengfei Ma, Ning Xie, Yuan Gao, Jiani Fu, Chun E. Tan, Qiu E. Yang, Shaolin Wang, Zhangqi Shen, Quanjiang Ji, Julian Parkhill, Congming Wu, Yang Wang, Timothy R. Walsh, Jianzhong Shen   +13 more
doaj   +6 more sources

Temperature-Regulated IncX3 Plasmid Characteristics and the Role of Plasmid-Encoded H-NS in Thermoregulation [PDF]

Frontiers in Microbiology, 2022
Carbapenem-resistant Enterobacteriaceae (CRE) are a critical public health problem worldwide. Globally, IncX3-type plasmids have emerged as the predominant vehicles carrying the metallo-β-lactamase gene blaNDM. Although blaNDM-bearing IncX3 plasmids have
Liu Baomo, Liu Baomo, Shui Lili, Robert A. Moran, Willem van Schaik, Zhuo Chao   +5 more
doaj   +4 more sources

Occurrence of Highly Conjugative IncX3 Epidemic Plasmid Carrying blaNDM in Enterobacteriaceae Isolates in Geographically Widespread Areas [PDF]

Frontiers in Microbiology, 2018
The emergence of New Delhi metallo-β-lactamase (NDM) in common enterobacterial species is a major concern for healthcare. Early reports have revealed that the spread of NDM involved diverse and heterogeneous plasmids. Recently, the involvement of a rare,
Ya Wang, Man-Ki Tong, Kin-Hung Chow, Vincent Chi-Chung Cheng, Cindy Wing-Sze Tse, Alan Ka-Lun Wu, Raymond Wai-Man Lai, Wei-Kwang Luk, Dominic Ngai-Chong Tsang, Pak-Leung Ho   +9 more
doaj   +6 more sources

Molecular Characterization of blaNDM-Carrying IncX3 Plasmids: blaNDM-16b Likely Emerged from a Mutation of blaNDM-5 on IncX3 Plasmid [PDF]

Microbiology Spectrum, 2022
Dissemination of blaNDM, which is carried on the IncX3 plasmid, among Enterobacterales has been reported worldwide. In particular, blaNDM-5-carrying IncX3 plasmids can spread among several hosts, facilitating their dissemination.
Tsukasa Ariyoshi, Kotaro Aoki, Hiroaki Kubota, Kenji Sadamasu, Yoshikazu Ishii, Kazuhiro Tateda   +5 more
doaj   +2 more sources

Genotypic and Phenotypic Characterization of blaNDM–7-Harboring IncX3 Plasmid in a ST11 Klebsiella pneumoniae Isolated From a Pediatric Patient in China [PDF]

Frontiers in Microbiology, 2020
NDM-7, a variant of New Delhi metallo-beta-lactamases (NDM), has the highest carbapenem-hydrolyzing activity. NDM-7-producing enterobacteria have been reported in many countries.
Chunhong Shao, Yingying Hao, Yong Wang, Meijie Jiang, Yan Jin   +4 more
doaj   +2 more sources

Characterization of blaNDM-19-producing IncX3 plasmid isolated from carbapenem-resistant Escherichia coli and Klebsiella pneumoniae [PDF]

Heliyon
The increase in the prevalence of carbapenem-producing Enterobacterales (CPE) is a major threat, with the New Delhi metallo-β-lactamase (NDM) enzyme-producing CPEs being one of the major causative agents of healthcare settings infections.
Jennifer Moussa, Elie Nassour, Tamima Jisr, Mira El Chaar, Sima Tokajian   +4 more
doaj   +2 more sources

Identification and characterization of a novel incompatibility group X3 plasmid carrying blaNDM-1 in Enterobacteriaceae isolates with epidemiological links to multiple geographical areas in China [PDF]

Emerging Microbes and Infections, 2012
The New Delhi metallo-β-lactamase (NDM-1) is one of the most important resistance traits in Enterobacteriaceae. We characterized nine blaNDM-1 producing Enterobacteriaceae recovered from seven patients who have recently travelled or been treated in India
Pak-Leung Ho, Zhen Li, Wai-U Lo, Yuk-Yam Cheung, Chi-Ho Lin, Pak-Chung Sham, Vincent Chi-Chung Cheng, Tak-Keung Ng, Tak-Lun Que, Kin-Hung Chow   +9 more
doaj   +3 more sources

Rectal Carriage of Sequence Type 307 Klebsiella pneumoniae High-Risk Clone Harboring Multiple Carbapenemase Genes in Community Hospitals Gauteng, South Africa. [PDF]

Microbiologyopen
Graphical presentation of rectal carriage of carbapenem‐resistant Klebsiella pneumoniae, highlighting ST307 high‐risk clone and IncX3 plasmid‐associated blaOXA‐181. This study highlights the threat linked to horizontal gene transfer of AMR genes by epidemic plasmids from Klebsiella pneumoniae high‐risk clones to other bacterial species.
Salvador-Oke KT, Pitout J, Peirano G, Strydom KA, Kingsburgh C, Ehlers M, Kock M.   +6 more
europepmc   +2 more sources

Double Copies of bla(KPC-3)::Tn4401a on an IncX3 Plasmid in Klebsiella pneumoniae Successful Clone ST512 from Italy. [PDF]

Antimicrob Agents Chemother, 2016
A carbapenem-resistant sequence type 512 (ST512) Klebsiella pneumoniae carbapenemase 3 (KPC-3)-producing K. pneumoniae strain showing a novel variant plasmid content was isolated in Palermo, Italy, in 2014.
Fortini D, Villa L, Feudi C, Pires J, Bonura C, Mammina C, Endimiani A, Carattoli A.   +7 more
europepmc   +5 more sources

First Report of OXA-181-Producing Enterobacterales Isolates in Latin America [PDF]

Microbiology Spectrum, 2023
We characterized five carbapenemase-producing Enterobacterales (CPE) isolates from two health care institutions in Lima, Peru. The isolates were identified as Klebsiella pneumoniae (n = 3), Citrobacter portucalensis (n = 1), and Escherichia coli (n = 1).
Diego Cuicapuza, Luis Alvarado, Norah Tocasca, Daniel Aguilar, Juan Carlos Gómez-de-la-Torre, Guillermo Salvatierra, Pablo Tsukayama, Jesús Tamariz   +7 more
doaj   +3 more sources