Results 21 to 30 of about 2,171 (161)

Adaptive Evolution Compensated for the Plasmid Fitness Costs Brought by Specific Genetic Conflicts

Pathogens, 2023
New Delhi metallo-β-lactamase (NDM)-carrying IncX3 plasmids is important in the transmission of carbapenem resistance in Escherichia coli. Fitness costs related to plasmid carriage are expected to limit gene exchange; however, the causes of these fitness
Feifeng Li, Jiong Wang, Ying Jiang, Yingyi Guo, Ningjing Liu, Shunian Xiao, Likang Yao, Jiahui Li, Chuyue Zhuo, Nanhao He, Baomo Liu, Chao Zhuo   +11 more
doaj   +1 more source

In silico Evolution and Comparative Genomic Analysis of IncX3 Plasmids Isolated From China Over Ten Years

Frontiers in Microbiology, 2021
IncX3 plasmids are correlated with the dissemination and acquisition of carbapenem resistance in Enterobacteriaceae and have been prevalent in China over the last 10 years.
Baomo Liu, Baomo Liu, Yingyi Guo, Ningjing Liu, Jiong Wang, Feifeng Li, Likang Yao, Chao Zhuo   +7 more
doaj   +1 more source

Dissemination and Stability of the bla_NDM-5-Carrying IncX3-Type Plasmid among Multiclonal Klebsiella pneumoniae Isolates

mSphere, 2020
NDM-5 carbapenemase was mainly identified in Escherichia coli, while the rapid transmission of blaNDM-5 among Enterobacteriaceae has raised serious public attention.
Wenjun Zhu, Xing Wang, Juanxiu Qin, Wei Liang, Zhen Shen   +4 more
doaj   +1 more source

Genetic and phenotypic characterizations of IncX3 plasmids harboring bla NDM-5 and bla NDM-16b in Japan

Microbiology Spectrum, 2023
The spread of the gene encoding the NDM-type carbapenemase, bla NDM, poses a serious threat to clinical practice and public health. This gene is usually carried by transferable plasmids, which facilitates its rapid spread among various species of ...
Hui Zuo, Yo Sugawara, Shizuo Kayama, Sayoko Kawakami, Koji Yahara, Motoyuki Sugai   +5 more
doaj   +1 more source

Molecular characterization and comparison of bla NDM-1-carrying and bla NDM-5-harboring IncX3-type plasmids in carbapenem-resistant Klebsiella pneumoniae

Microbiology Spectrum, 2023
Carbapenem-resistant Klebsiella pneumoniae (CRKP), which harbors the bla NDM plasmid, has been reported extensively and is considered a global threat clinically.
Yunxing Yang, Haiyang Liu, Lingxia Chen, Minjie Mao, Xiaofan Zhang, Longjie Zhou, Darong Duan, Xi Li, Hua Zhou   +8 more
doaj   +1 more source

Klebsiella Species and Enterobacter cloacae Isolates Harboring blaOXA-181 and blaOXA-48: Resistome, Fitness Cost, and Plasmid Stability

Microbiology Spectrum, 2022
IncX3 and IncL plasmids have been named as catalysts advancing dissemination of blaOXA-181 and blaOXA-48 genes. However, their impact on the performance of host cells is vastly understudied. Genetic characteristics of blaOXA-48- and blaOXA-181-containing
Samiratu Mahazu, Isaac Prah, Yusuke Ota, Takaya Hayashi, Yoko Nukui, Masato Suzuki, Yoshihiko Hoshino, Yukihiro Akeda, Toshihiko Suzuki, Tomoko Ishino, Anthony Ablordey, Ryoichi Saito   +11 more
doaj   +1 more source

Fitness Cost of bla_NDM-5-Carrying p3R-IncX3 Plasmids in Wild-Type NDM-Free Enterobacteriaceae

Microorganisms, 2020
The wide dissemination of New Delhi metallo-β-lactamase genes (blaNDM) has resulted in the treatment failure of most available β-lactam antibiotics, with IncX3-type blaNDM-5-carrying plasmids recognised as having spread worldwide.
Tengfei Ma, Jiani Fu, Ning Xie, Shizhen Ma, Lei Lei, Weishuai Zhai, Yingbo Shen, Chengtao Sun, Shaolin Wang, Zhangqi Shen, Yang Wang, Timothy R. Walsh, Jianzhong Shen   +12 more
doaj   +1 more source

NDM-5-Producing Escherichia coli Co-Harboring mcr-1 Gene in Companion Animals in China

Animals, 2022
Carbapenem and colistin are important antibiotics for the treatment of infections caused by multidrug-resistant Gram-negative pathogens. Here, we isolated the blaNDM-5-harboring Escherichia coli in companion animals in healthy or diseased companion ...
Xu Kuang, Runshi Yang, Xinqing Ye, Jian Sun, Xiaoping Liao, Yahong Liu, Yang Yu   +6 more
doaj   +1 more source

Insights into a Novel blaKPC-2-Encoding IncP-6 Plasmid Reveal Carbapenem-Resistance Circulation in Several Enterobacteriaceae Species from Wastewater and a Hospital Source in Spain [PDF]

, 2017
Untreated wastewater, particularly from hospitals and other healthcare facilities, is considered to be a reservoir for multidrug-resistant bacteria.
Cantón, Rafael, Chakraborty, Trinad, Dominguez, Lucas, Falgenhauer, Linda, Imirzalioglu, Can, Lazaro-Perona, Fernando, Mingorance, Jesús, Valverde, Aránzazu, Yao, Yancheng   +8 more
core   +1 more source

Co‐localization of clinically relevant antibiotic‐ and heavy metal resistance genes on plasmids in Klebsiella pneumoniae from marine bivalves

MicrobiologyOpen, Volume 12, Issue 4, August 2023., 2023
Klebsiella pneumoniae is an opportunistic pathogen frequently associated with antibiotic resistance and present in a wide range of environments. In this study, five antibiotic‐resistant K. pneumoniae isolates recovered from bivalves, of which four also carried heavy metal resistance genes, were selected for complete genome sequencing.
Fredrik Håkonsholm, Marit A. K. Hetland, Iren H. Löhr, Bjørn Tore Lunestad, Nachiket P. Marathe   +4 more
wiley   +1 more source