Results 61 to 70 of about 127,927 (175)

Table_1_In silico characterization of IncX3 plasmids carrying blaOXA-181 in Enterobacterales.xlsx

, 2022
Carbapenem-resistant Enterobacterales poses a global urgent antibiotic resistance threat because of its ability to transfer carbapenemase genes to other bacteria via horizontal gene transfer mediated by mobile genetic elements such as plasmids ...
Zhixiong Zheng (13757638), Shengni Hua (417714), Zhijian Yu (778086), Zhengrong Zhang (838088), Xiaobin Li (750526), Mubiao Liu (13757644), Xiaosan Feng (13757641), Ting Luan (10533029), Lile Shi (13757635), Qiuping Lin (3091146)   +9 more
core   +1 more source

Characterization of an International High-Risk Escherichia coli ST410 Clone Coproducing NDM-5 and OXA-181 in a Food Market in China

Microbiology Spectrum, 2023
During a 2020 routine epidemiological investigation of carbapenem-resistant Enterobacterales at a local food market in Guangzhou, China, two Escherichia coli ST410 isolates coproducing NDM-5 and OXA-181 were obtained from environmental samples ...
Wan-Yun He, Lu-Chao Lv, Wen-Xian Pu, Guo-Long Gao, Zi-Lin Zhuang, Yao-Yao Lu, Chao Zhuo, Jian-Hua Liu   +7 more
doaj   +1 more source

Type IV‐Dominated Plasmid‐Encoded CRISPR‐Cas Systems Are Enriched in Multireplicon and Multi‐Stressor Resistance Plasmids Across the Global Plasmidome

Molecular Microbiology, EarlyView.
Screening 72,555 plasmid sequences reveals that intact CRISPR‐Cas systems are rare (1.03%) but strongly enriched in multireplicon and multi‐stressor resistance plasmids, with Type IV‐A as the dominant subtype. These findings implicate plasmid‐encoded CRISPR‐Cas as non‐randomly retained elements of structurally complex and high‐risk backbones.
Hannay Crystynah Almeida de Souza, Anamaria Mota Pereira dos Santos, Arlen Carvalho de Oliveira Almeida, Carlos Adam Conte Junior, Pedro Panzenhagen   +4 more
wiley   +1 more source

Longitudinal Molecular Epidemiology and Genomic Surveillance of Carbapenem‐Resistant Klebsiella pneumoniae in the Gut of Healthy Individuals in China

MedComm, Volume 7, Issue 8, August 2026.
Using 16,040 stool samples from healthy individuals across 30 Chinese provinces (2016–2024), we performed longitudinal genomic surveillance of carbapenem‑resistant Klebsiella pneumoniae (CRKP) colonizing the gut. We reveal rising community CRKP prevalence, especially in southern China, a shift from blaKPC‐2 to plasmid‑borne blaNDM‐5 on IncHI2/IncHI2A ...
Zelin Yan, Yan Li, Yi Sun, Qiaoling Sun, Congcong Liu, Yanyan Zhang, Yuchen Wu, Hongwei Zhou, Shangshang Qin, Gongxiang Chen, Ruichao Li, Rong Zhang   +11 more
wiley   +1 more source

Coexistence of Two blaNDM–5 Genes Carried on IncX3 and IncFII Plasmids in an Escherichia coli Isolate Revealed by Illumina and Nanopore Sequencing

Frontiers in Microbiology, 2020
The emergence of carbapenem-resistant Enterobacteriaceae poses a significant threat to public health worldwide. Here, we reported a multidrug-resistant Escherichia coli strain with two different blaNDM–5-carrying plasmids from China.
Lang Yang, Lang Yang, Yanfeng Lin, Yanfeng Lin, Lanfen Lu, Mei Xue, Hui Ma, Xuguang Guo, Kaiying Wang, Kaiying Wang, Peihan Li, Peihan Li, Xinying Du, Kezong Qi, Peng Li, Hongbin Song   +15 more
doaj   +1 more source

Data_Sheet_1_In silico Evolution and Comparative Genomic Analysis of IncX3 Plasmids Isolated From China Over Ten Years.docx

, 2021
IncX3 plasmids are correlated with the dissemination and acquisition of carbapenem resistance in Enterobacteriaceae and have been prevalent in China over the last 10 years.
Chao Zhuo (277585), Baomo Liu (3619250), Jiong Wang (440497), Ningjing Liu (11471192), Yingyi Guo (11471189), Feifeng Li (11471198), Likang Yao (11471201)   +6 more
core   +1 more source

Eco‐Geography Reverses Dominant AMR Reservoirs in Klebsiella pneumoniae: Integron‐Rich Mobilomes and Cross‐Niche Connectivity

Advanced Science, Volume 13, Issue 42, 28 July 2026.
Dominant antimicrobial resistance reservoirs in Klebsiella pneumoniae vary across eco‐geographic settings rather than following a universal pattern. Integrated One Health and global genomic analyses show that lineage structure, integron load, and cross‐niche connectivity shape whether AMR burden accumulates primarily in human or nonhuman compartments ...
Hui Lin, Biao Tang, Hao Xu, Jiajie Qian, Feifan Shi, Junhui Zhao, Xiaorui Mao, Xiaohe Hu, Ruishan Liu, Wenhong Liu, Xiawei Jiang, Beiwen Zheng, Guoping Zhao   +12 more
wiley   +1 more source

Table_3_In silico characterization of IncX3 plasmids carrying blaOXA-181 in Enterobacterales.xlsx

, 2022
Carbapenem-resistant Enterobacterales poses a global urgent antibiotic resistance threat because of its ability to transfer carbapenemase genes to other bacteria via horizontal gene transfer mediated by mobile genetic elements such as plasmids ...
Zhixiong Zheng (13757638), Shengni Hua (417714), Zhijian Yu (778086), Zhengrong Zhang (838088), Xiaobin Li (750526), Mubiao Liu (13757644), Xiaosan Feng (13757641), Ting Luan (10533029), Lile Shi (13757635), Qiuping Lin (3091146)   +9 more
core   +1 more source

VirBR counter-silences HppX3 to promote conjugation of blaNDM-IncX3 plasmids

Nucleic Acids Research
Abstract New Delhi metallo-β-lactamases (NDM), encoded by the blaNDM gene, mediate carbapenem resistance, posing serious threats to public health due to their global presence across diverse hosts and environments. The blaNDM is prominently carried by the IncX3 plasmid, which encodes a Type IV secretion system (T4SS) responsible for ...
Yuan Gao, Ning Xie, Tengfei Ma, Chun E Tan, Zhuo Wang, Rong Zhang, Shizhen Ma, Zhaoju Deng, Yang Wang, Jianzhong Shen   +9 more
openaire   +2 more sources

Identification and characterization of a novel incompatibility group X3 plasmid carrying blaNDM-1 in Enterobacteriaceae isolates with epidemiological links to multiple geographical areas in China

Emerging Microbes and Infections, 2012
The New Delhi metallo-β-lactamase (NDM-1) is one of the most important resistance traits in Enterobacteriaceae. We characterized nine blaNDM-1 producing Enterobacteriaceae recovered from seven patients who have recently travelled or been treated in India
Pak-Leung Ho, Zhen Li, Wai-U Lo, Yuk-Yam Cheung, Chi-Ho Lin, Pak-Chung Sham, Vincent Chi-Chung Cheng, Tak-Keung Ng, Tak-Lun Que, Kin-Hung Chow   +9 more
doaj   +1 more source