Worldwide Disseminated IncX4 Plasmid Carrying mcr-1 Arrives to Wild Mammal in Portugal [PDF]
Microbiology Spectrum, 2022 The mcr-1 gene spread is worldwide recognized as a public health threat at multidrug-resistant infections therapy level. Here, we report for the first time, to the best of our knowledge, the detection of the globally distributed IncX4 plasmid carrying ...
Josman Dantas Palmeira +4 more
doaj +8 more sources
Genomic Evidence of mcr-1.26 IncX4 Plasmid Transmission between Poultry and Humans [PDF]
Microbiology Spectrum, 2023 Colistin is still commonly used and misused in animal husbandry driving the evolution and dissemination of transmissible plasmid-mediated colistin resistance (mcr).
Ulrike Binsker +5 more
doaj +5 more sources
Fitness Advantage of mcr-1–Bearing IncI2 and IncX4 Plasmids in Vitro [PDF]
Frontiers in Microbiology, 2018 The objective of this study was to assess the impact of diverse plasmids bearing colistin resistance gene mcr-1 on host fitness. Forty-seven commensal E.
Renjie Wu +8 more
doaj +5 more sources
Emergence of IncX4 plasmids encoding mcr-1 in a clinical isolate of Klebsiella pneumoniae in Japan [PDF]
International Journal of Infectious Diseases, 2018 The mcr-1 gene encodes a phosphoethanolamine transferase that confers resistance to colistin by transferring phosphoethanolamine to lipid A. A 33-kb IncX4 plasmid harboring mcr-1 was detected in a Klebsiella pneumoniae isolate and two Escherichia coli ...
Tatsuya Tada +7 more
doaj +5 more sources
Genetic Analysis of the IncX4 Plasmids: Implications for a Unique Pattern in the mcr-1 Acquisition
Scientific Reports, 2017 IncX4 plasmids are associated with the dissemination of the mcr-1 genes in Enterobacteriaceae. We screened IncX4 plasmids among 2,470 isolates of Enterobacteriaceae and determined the mcr-1 positive isolates.
Jian Sun +9 more
doaj +4 more sources
Inhibitory effects of benzyl isothiocyanate on widespread mcr-1-harbouring IncX4 plasmid transfer [PDF]
Scientific ReportsThe global dissemination of mobile colistin resistance (mcr) genes represents a significant public health threat due to colistin’s critical role in treating multidrug-resistant (MDR) bacterial infections. We identified high rates of carbapenem resistance
Sirirat Luk-In +11 more
doaj +4 more sources
First detection and genomic analysis of mcr-1-positive Salmonella Infantis isolated from a broiler production system in the United Arab Emirates [PDF]
Frontiers in Veterinary ScienceThis study reports the first detection of mcr-1.1-mediated colistin resistance in Salmonella enterica serovar Infantis from a commercial broiler farm in the United Arab Emirates (UAE). Two S.
Ihab Habib +8 more
doaj +5 more sources
Case Report: Transferable IncX4 plasmid carrying mcr-1 in colistin-resistant Escherichia coli from a healthy pet dog in South Korea [PDF]
Frontiers in Veterinary ScienceColistin resistance mediated by the plasmid-borne mcr-1 gene presents a significant challenge in both human and veterinary medicine. While colistin-resistant bacteria have been reported in food-producing animals and humans, mcr-1-harboring strains remain
Jae Young Oh +8 more
doaj +2 more sources
PixR, a Novel Activator of Conjugative Transfer of IncX4 Resistance Plasmids, Mitigates the Fitness Cost of mcr-1 Carriage in Escherichia coli [PDF]
mBio, 2022 The emergence of the plasmid-borne colistin resistance gene mcr-1 threatens public health. IncX4-type plasmids are one of the most epidemiologically successful vehicles for spreading mcr-1 worldwide.
Lingxian Yi +6 more
doaj +3 more sources
Frontiers in Microbiology, 2022 Colistin is a last-resort antibiotic used in the treatment of multidrug resistant Gram-negative bacteria. However, the activity and efficacy of colistin has been compromised by the worldwide spread of the mobile colistin resistance genes (mcr-1 to mcr-10)
Ahmed M. Soliman +13 more
doaj +3 more sources