Results 21 to 30 of about 1,638 (164)

Tracking Global Transmission Dynamics of the Plasmid-Mediated mcr Gene: A Genomic Epidemiological Analysis [PDF]

Microorganisms
The emergence and spread of mobile colistin resistance (mcr) genes pose a significant challenge in controlling multidrug-resistant Gram-negative pathogens.
Jinzhao Long, Xin Wang, Mengyue Liu, Jie Wu, Haiyan Yang, Shuaiyin Chen, Guangcai Duan   +6 more
doaj   +2 more sources

Coexistence of blaKPC-2–IncN and mcr-1–IncX4 plasmids in a ST48 Escherichia coli strain in China

Journal of Global Antimicrobial Resistance, 2020
Objectives: The aim of this study was to explore the genomic content of a blaKPC-2- and mcr-1-harbouring Escherichia coli strain and to clarify the molecular mechanism for the transmission of multidrug resistance.
Yanfei Wang, Haiyang Liu, Qian Wang, Xiaoxing Du, Yunsong Yu, Yan Jiang   +5 more
doaj   +3 more sources

One Health at Risk: Plasmid-Mediated Spread of mcr-1 Across Clinical, Agricultural, and Environmental Ecosystems [PDF]

Antibiotics
The global dissemination of plasmid-mediated mcr genes, which confer resistance to the last-resort antibiotic colistin, represents a critical public health challenge driven by the interplay of clinical, agricultural, and environmental factors.
Abdelaziz Touati, Nasir Adam Ibrahim, Assia Mairi, Hassina Kirat, Nosiba S. Basher, Takfarinas Idres   +5 more
doaj   +2 more sources

mcr-Colistin resistance genes mobilized by IncX4, IncHI2, and IncI2 plasmids in Escherichia coli of pigs and white stork in Spain [PDF]

Frontiers in Microbiology, 2020
Colistin has become the last-line antimicrobial for the treatment of multidrug resistant (MDR) Enterobacterales in human medicine. To date, several colistin resistance genes have been described. Of them mcr-1 is disseminated worldwide in Escherichia coli
Aguirre Sánchez, J. R., Gonzalez-Escalona, Narjol, González-López, Juan J., Höfle, Ursula, Martinez-Urtaza, Jaime, Migura-Garcia, Lourdes, Moreno-Mingorance, A., Perez de Rozas, A., Ramiro, Y.   +8 more
core   +13 more sources

The Mobile Colistin Resistance Gene, mcr-1.1, Is Carried on IncX4 Plasmids in Multidrug Resistant E. coli Isolated from Rainbow Trout Aquaculture [PDF]

Microorganisms, 2020
Colistin, a last resort antibiotic, is important for controlling infections with carbapenem-resistant Enterobacteriaceae. The recent emergence of mobile-colistin-resistance (mcr) genes has threatened the effectiveness of colistin. Aquaculture is hypothesized to be a major contributor to the evolution and dissemination of mcr.
Shaoting Li, Xiangyu Deng, Issmat I Kassem   +2 more
exaly   +4 more sources

The Co-Existence of mcr-1.1 and mcr-3.5 in Escherichia coli Isolated from Clinical Samples in Thailand [PDF]

Antibiotics
The emergence of colistin resistance poses a significant threat to its efficacy as a last-line treatment against multidrug-resistant Gram-negative bacterial infections.
Panida Nobthai, Sirigade Ruekit, Dutsadee Peerapongpaisarn, Prawet Sukhchat, Brett E. Swierczewski, Nattaya Ruamsap, Paphavee Lertsethtakarn   +6 more
doaj   +2 more sources

Complete Sequence of pSAM7, an IncX4 Plasmid Carrying a Novel bla[sub]CTX-M-14b Transposition Unit Isolated from ' Escherichia coli ' and ' Enterobacter cloacae ' from cattle [PDF]

Antimicrobial Agents and Chemotherapy, 2013
The same plasmid carrying blaCTX-M-14b was identified from an Escherichia coli isolate and an Enterobacter cloacae isolate collected from cattle in the United Kingdom by complete plasmid sequencing.
AbuOun, M., Coldham, N. G., Fielder, M. D., Mevius, D. J., Partridge, S. R., Stokes, M.O., Umur, S., Wu, G.   +7 more
core   +7 more sources

Molecular characterization of mcr-1.1-harboring multidrug-resistant Escherichia coli isolates from chicken in the United Arab Emirates: implications for one health surveillance [PDF]

Frontiers in Veterinary Science
BackgroundThe mcr-1.1 gene, conferring resistance to colistin, is a significant threat to public health, particularly due to its capacity for horizontal gene transfer between diverse bacterial populations in humans, animals, and the food chain.
Hazim O. Khalifa, Mohammed Elbediwi, Mohammed Elbediwi, Temesgen Mohammed, Afra Abdalla, Mohamed-Yousif Ibrahim Mohamed, Mohamed-Yousif Ibrahim Mohamed, Glindya Bhagya Lakshmi, Glindya Bhagya Lakshmi, Ihab Habib, Ihab Habib   +10 more
doaj   +2 more sources

Whole Genome Sequencing and Characteristics of mcr-1–Harboring Plasmids of Porcine Escherichia coli Isolates Belonging to the High-Risk Clone O25b:H4-ST131 Clade B [PDF]

Frontiers in Microbiology, 2020
Porcine Escherichia coli ST131 isolates are scarcely documented. Here, whole genome sequencing and core genome (CG) and plasmidome analysis of seven isolates collected from diarrheic piglets and four from pork meat were performed.
Saskia-Camille Flament-Simon, Saskia-Camille Flament-Simon, María de Toro, Azucena Mora, Azucena Mora, Vanesa García, Vanesa García, Isidro García-Meniño, Isidro García-Meniño, Dafne Díaz-Jiménez, Dafne Díaz-Jiménez, Alexandra Herrera, Jorge Blanco, Jorge Blanco   +13 more
doaj   +3 more sources

Plasmid-Driven Resistome Diversity in 9700 Escherichia coli Genomes Across Phylogroups and Sequence Types [PDF]

Antibiotics
Background/Objectives: Plasmids are key vehicles for the dissemination of antimicrobial resistance (AMR), yet their contribution to the global resistome architecture of Escherichia coli remains poorly resolved.
Adel Azour, Ghassan M. Matar, Melhem Bilen   +2 more
doaj   +2 more sources